This Ruth L. Kirschstein National Research Service Award Postdoctoral Research Training Grant renewal application is submitted in response to Program Announcement # PA-11-184 for applications to provide institutional T32 awards to train young researchers who will become independent investigators conducting research that addresses important problems in human health. The application requests continued resources to support four physician/scientists each year with MD or MD/PhD degrees who receive mentored research that focuses on the etiology, pathogenesis, and treatment of pediatric malignancies. The overall objective of this T32 program is to train new investigators who will improve the care of children with cancer. The rationale for the program is based on the substantial burden of pediatric cancer in the United States and the well-documented need to provide mentored career development support for young scientists that will enable them to become fully independent and productive laboratory researchers. As such, they will be poised to improve the health of children with cancer throughout the world by bringing state-of-the-art expertise to bear on problems such as inherited predispositions, environmental factors, the toxic and relatively non-specific nature of current therapies, and long-term adverse effects of mutagenic treatments. The design of this program involves harnessing the expertise of world-class research scientists who will serve as mentors for interdisiciplinary training. We have successfully implemented distinct training tracks for laboratory-based and clinical/translational investigators. We believe that the progress of this T32 program since its inception in 2007 demonstrates that UCSF has the vision, experience, and infrastructure to train the next generation of leaders in childhood cancer research. In this renewal application, we provide evidence that the Department together with the broader UCSF research community comprise an exceptional environment for preparing young investigators for productive careers in this field and describe a comprehensive plan for training and mentoring these individuals.

Public Health Relevance

This application is directly relevant to human health as it requests funds to support mentored career development for outstanding young physician/investigators who will become independent researchers in the field of childhood cancer. Programs like this one represent an investment in the future of public health as the researchers who are trained through this award will be equipped to harness state-of-the-art research techniques to attack a formidable health problem in the pediatric population. The long-term outcome of intensive and innovative training provided by this T32 award will be effective new treatments for childhood cancers.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Schools of Medicine
San Francisco
United States
Zip Code
Karski, Erin E; Dvorak, Christopher C; Leung, Wing et al. (2014) Treatment of hepatoblastoma with high-dose chemotherapy and stem cell rescue: the pediatric blood and marrow transplant consortium experience and review of the literature. J Pediatr Hematol Oncol 36:362-8
Gill, Saar; Tasian, Sarah K; Ruella, Marco et al. (2014) Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells. Blood 123:2343-54
Yu, Dan; Gustafson, William Clay; Han, Chun et al. (2014) An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun 5:3626
Tasian, Sarah K; Teachey, David T; Rheingold, Susan R (2014) Targeting the PI3K/mTOR Pathway in Pediatric Hematologic Malignancies. Front Oncol 4:108
Johnson, Brett E; Mazor, Tali; Hong, Chibo et al. (2014) Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343:189-93
Tasian, Sarah K; Pollard, Jessica A; Aplenc, Richard (2014) Molecular therapeutic approaches for pediatric acute myeloid leukemia. Front Oncol 4:55
Stieglitz, Elliot; Liu, Y Lucy; Emanuel, Peter D et al. (2014) Mutations in GATA2 are rare in juvenile myelomonocytic leukemia. Blood 123:1426-7
Huang, Miller; Weiss, William A (2013) Neuroblastoma and MYCN. Cold Spring Harb Perspect Med 3:a014415
Swartling, Fredrik J; Hede, Sanna-Maria; Weiss, William A (2013) What underlies the diversity of brain tumors? Cancer Metastasis Rev 32:5-24
Huang, Miller; Weiss, William A (2013) G34, another connection between MYCN and a pediatric tumor. Cancer Discov 3:484-6

Showing the most recent 10 out of 16 publications