The University of Iowa has independently funded and established mentors in Surgical Oncology to train the next generation of surgeon-scientists to independently conduct basic, translational and clinical research. Trainees will be MD or MO PhD post-graduates who have completed at least two years of surgical residency training. Three training slots per year are sought in a typical two year training program in either a Basic Science or Clinical Research Track. Program leadership is provided by the Head of the Department of Surgery, who serves as Chair of the eight member Executive Committee. Three Associate Directors for Basic Science Research help administer the Basic Science Research Track. Three Associate Directors for Clinical Research help administer the Clinical Research Track. The Executive Committee will monitor progress through periodic oral and written reports from both the Trainee and the individual Trainee's three or four member Trainee Advisory Committee. Preceptors actively collaborate through the University of Iowa's NCI-designated Holden Comprehensive Cancer Center and the NIH-designed Institute for Clinical and Translational Science. Additional guidance will be provided by a six member External Advisory Committee, comprised of national leaders in Surgical Oncology with experience in administrating T32 training programs. Two Diversity Advisers (one internal, one external) will assist in recruitment and retention of underrepresented Trainees. Research training will consist of: (1) required core curriculum including training in research design, management, ethics and data analysis, (2) an individualized curriculum developed in collaboration with the Preceptor and Trainee Advisory Committee, (3) Preceptor-directed research project in either a basic science laboratory or clinical research group, (4) basic and clinical science-oriented interactive seminars, and (5) attendance at national meetings. Trainees will be provided with the fundamental skill sets, knowledge and experience needed to successfully compete for independent research funding in Surgical Oncology.

Public Health Relevance

The need for surgical oncologists trained in research disciplines is critical. Surgeons are often the first health care professionals to treat cancer patients. A thorough understanding of cancer biology is essential in enabling the surgeon to advance the treatment of patients with solid organ malignancies and to be a successful clinician in a multidisciplinary team.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
3T32CA148062-04S1
Application #
8644985
Study Section
Subcommittee G - Education (NCI)
Program Officer
Ogunbiyi, Peter
Project Start
2010-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$62,075
Indirect Cost
$4,395
Name
University of Iowa
Department
Surgery
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Bogachek, Maria V; De Andrade, James P; Weigel, Ronald J (2015) Regulation of epithelial-mesenchymal transition through SUMOylation of transcription factors. Cancer Res 75:5-Nov
Maxwell, Jessica E; Sherman, Scott K; Stashek, Kristen M et al. (2014) A practical method to determine the site of unknown primary in metastatic neuroendocrine tumors. Surgery 156:1359-65; discussion 1365-6
Bogachek, Maria V; Chen, Yizhen; Kulak, Mikhail V et al. (2014) Sumoylation pathway is required to maintain the basal breast cancer subtype. Cancer Cell 25:748-61
Sherman, Scott K; Maxwell, Jessica E; O'Dorisio, M Sue et al. (2014) Pancreastatin predicts survival in neuroendocrine tumors. Ann Surg Oncol 21:2971-80
Maxwell, Jessica E; Sherman, Scott K; Menda, Yusuf et al. (2014) Limitations of somatostatin scintigraphy in primary small bowel neuroendocrine tumors. J Surg Res 190:548-53
Sibenaller, Zita A; Welsh, Jessemae L; Du, Changbin et al. (2014) Extracellular superoxide dismutase suppresses hypoxia-inducible factor-1? in pancreatic cancer. Free Radic Biol Med 69:357-66
Wertzberger, Brittany E; Sherman, Scott K; Byrn, John C (2014) Differences in short-term outcomes among patients undergoing IPAA with or without preoperative radiation: a National Surgical Quality Improvement Program analysis. Dis Colon Rectum 57:1188-94
Hagen, Jussara; Muniz, Viviane P; Falls, Kelly C et al. (2014) RABL6A promotes G1-S phase progression and pancreatic neuroendocrine tumor cell proliferation in an Rb1-dependent manner. Cancer Res 74:6661-70
Maxwell, Jessica E; O'Dorisio, Thomas M; Bellizzi, Andrew M et al. (2014) Elevated pancreatic polypeptide levels in pancreatic neuroendocrine tumors and diabetes mellitus: causation or association? Pancreas 43:651-6
Lorenzen, Allison W; Sherman, Scott K; Rosenbaum, Marcy et al. (2014) Resident involvement in postoperative conversations: an underused opportunity. J Surg Res 190:437-44

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