The important and primary goal of the Training Program in Skin Biology and Cancer is to provide state-of-the-art interdisciplinary basic research training for graduate students and postdoctoral fellows who seek a career in the strongly interwoven skin biology-skin cancer discipline. Specifically, the training program will offer pre- and postdoctoral fellows a unique opportunity to obtain by way of molecular, immunologic, and bioengineering studies, important scientific insights into the biology of skin regeneration, inherited skin disorders, and closely linked to it, skin cancer. The faculty serving as mentors of this unique and cohesive training program, have a long-standing and strong commitment to training young scientists in interdisciplinary research ranging from wound healing and scarring, skin repair and tissue replacement, to molecular and immunologic studies of skin neoplasia. The mentors of the training program are united in their commitment to recruit and train the next generation of scientists who will expand this strongly interconnected area of skin research, and pursue research that will continue to be at the forefront of this field.
The training program proposed in this application seeks to train graduate students and postdoctoral fellows in the field of skin biology and skin cancer. Training of the next generation of scientists in this strongly interwoven discipline is essential t the progress of research into scaring and wound healing, regeneration and engineering of skin tissue, and an understanding of melanoma and Merkel Cell carcinoma, the two most aggressive skin cancers.
|Nuschke, Austin; Rodrigues, Melanie; Rivera, Jaime et al. (2016) Epidermal Growth Factor Tethered to Î²-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. Stem Cells Transl Med :|
|Wells, Alan; Nuschke, Austin; Yates, Cecelia C (2016) Skin tissue repair: Matrix microenvironmental influences. Matrix Biol 49:25-36|
|Nuschke, Austin; Rodrigues, Melanie; Wells, Albin W et al. (2016) Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation. Stem Cell Res Ther 7:179|
|Richards, Kathleen F; Guastafierro, Anna; Shuda, Masahiro et al. (2015) Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression. J Gen Virol 96:3532-44|
|Nuschke, Austin; Rodrigues, Melanie; Stolz, Donna B et al. (2014) Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation. Stem Cell Res Ther 5:140|