This application is a request for continuing support for a predoctoral NIDA Training Program in Neuroscience, which was founded at The University of Michigan (UM) in 1995. The major goal of the Program is to recruit and develop student interest in research related to the biological basis of substance abuse, and to provide the necessary administrative, faculty and educational resources for students with these interests to pursue a Ph.D. degree in the field of neuroscience. To be eligible for support by the NIDA Training Program students first must gain admittance to an existing UM graduate program in the biological, biomedical or natural sciences, such as the Interdepartmental Graduate Program in Neuroscience. Students nominated for support by the NIDA Training Program in Neuroscience are selected on the basis of two criteria: (a) academic qualifications and references (i.e., academic excellence), and (b) the relevance of their program of study and research to the NIDA mission. After admission to the NIDA Training Program students pursue a program of study in the neurosciences, including a required course on the neuropsychopharmacology of substance abuse. The Training Faculty in the NIDA Training Program in Neuroscience consists of eighteen faculties, all of whom conduct research related to the biological basis of substance abuse. Most faculty are PI or Co-PI on a NIDA-funded research grant. The training grant is used primarily to foster interest in students to do research rotations, and then their dissertation research, on the neurobiology of substance abuse by working with Training Faculty. Collectively, Training Faculty provides considerable expertise in the neurobiology and biopsychology of many drugs of abuse. In addition, NIDA Training Program faculty are assisted by over 100 Neuroscience Resource Faculty. The latter provide invaluable assistance to the NIDA Training Program because of their involvement in many aspects of the Neuroscience Graduate Program. The NIDA Training Program is administered by a Director and a Co- Director, with the continuing advice of a three member Executive Committee.
The actions of drugs of abuse on the brain are fundamental to their adverse consequences, including addiction;a major public health problem. This grant is to foster interest in the next generation of researchers, early in their graduate studies, to devote their research and eventual career to studying this problem, in the hope of developing effective treatments.
|Saunders, Benjamin T; Janak, Patricia H (2014) Nucleus accumbens plasticity underlies multifaceted behavioral changes associated with addiction. Biol Psychiatry 75:92-3|
|Anand, Jessica P; Porter-Barrus, Vanessa R; Waldschmidt, Helen V et al. (2014) Translation of structure-activity relationships from cyclic mixed efficacy opioid peptides to linear analogues. Biopolymers 102:107-14|
|Fraser, Rheaclare; Chen, Yongyue; Guptaroy, Bipasha et al. (2014) An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporter. Mol Pharmacol 86:76-85|
|Mosberg, Henry I; Yeomans, Larisa; Anand, Jessica P et al. (2014) Development of a bioavailable ? opioid receptor (MOPr) agonist, ? opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. J Med Chem 57:3148-53|
|Briand, Lisa A; Kimmey, Blake A; Ortinski, Pavel I et al. (2014) Disruption of glutamate receptor-interacting protein in nucleus accumbens enhances vulnerability to cocaine relapse. Neuropsychopharmacology 39:759-69|
|Robinson, Terry E; Yager, Lindsay M; Cogan, Elizabeth S et al. (2014) On the motivational properties of reward cues: Individual differences. Neuropharmacology 76 Pt B:450-9|
|Wakabayashi, Ken T; Kiyatkin, Eugene A (2014) Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. J Neurochem 128:672-85|
|Calu, Donna J; Chen, Yu-Wei; Kawa, Alex B et al. (2014) The use of the reinstatement model to study relapse to palatable food seeking during dieting. Neuropharmacology 76 Pt B:395-406|
|Fitzpatrick, Christopher J; Gopalakrishnan, Shyam; Cogan, Elizabeth S et al. (2013) Variation in the form of Pavlovian conditioned approach behavior among outbred male Sprague-Dawley rats from different vendors and colonies: sign-tracking vs. goal-tracking. PLoS One 8:e75042|
|Martikainen, Ilkka K; Pecina, Marta; Love, Tiffany M et al. (2013) Alterations in endogenous opioid functional measures in chronic back pain. J Neurosci 33:14729-37|
Showing the most recent 10 out of 29 publications