This application is for renewal of a training program directed by Louis Hersh and co-directed by Linda Dwoskin and Sharon Walsh. We request continued support for four predoctoral and two postdoctoral trainees utilizing a training faculty of 15 housed in three colleges and 5 different departments within the University of Kentucky. All of the training faculty have been funded through NIDA or collaborate with NIDA funding training faculty with their research broadly focused on the molecular aspects of drug abuse. The University of Kentucky has a long history of involvement in drug abuse research and includes the Center on Drug and Alcohol Research and the Center for Drug and Alcohol Research and Translation. The goal of this training program continues to be the preparation of promising graduate students and postdoctoral fellows for careers in drug abuse research. The program provides broad-based training in modern aspects of drug abuse research with a particular emphasis on studying the cellular and molecular aspects of receptors involved in the response to drugs and the development of ligands which interact with these receptors as potential pharmacotherapy's for drug abuse. The training faculty share a common interest in understanding basic mechanisms related to drug abuse at the molecular level. The emphasis of the training faculty focus on the structure of opiate receptor ligands, the effects of opiate receptor ligands on physiological processes, and the structure and function of the proteins and ligands involved in opiate receptors. Trainees learn from a strong faculty who utilize state-of-the-art methodological approaches to drug abuse research. A unique aspect of this program is the interaction of trainees with other faculty and trainees involved in the behavioral aspects of drug abuse, giving them a broad based understanding of drug abuse research. This unique training opportunity is hoped to fill the need for new investigators in drug abuse research who have a broad understanding of the field.
This program is designed to train graduate students and postdocs for a career in drug abuse research, providing them with the tools to conduct research on the molecular aspects of drug abuse while at the same time endowing them with an understanding of the behavioral aspects of drug abuse.
|Nickell, Chelsea R Geil; Peng, Hui; Hayes, Dayna M et al. (2017) Type 2 Neural Progenitor Cell Activation Drives Reactive Neurogenesis after Binge-Like Alcohol Exposure in Adolescent Male Rats. Front Psychiatry 8:283|
|Shrestha, Sanjib K; Kril, Liliia M; Green, Keith D et al. (2017) Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents. Bioorg Med Chem 25:58-66|
|Heidary, David K; Fox, Ashley; Richards, Chris I et al. (2017) A High-Throughput Screening Assay Using a Photoconvertable Protein for Identifying Inhibitors of Transcription, Translation, or Proteasomal Degradation. SLAS Discov 22:399-407|
|Reynolds, Anna R; Strickland, Justin C; Stoops, William W et al. (2017) Buspirone maintenance does not alter the reinforcing, subjective, and cardiovascular effects of intranasal methamphetamine. Drug Alcohol Depend 181:25-29|
|Fox-Loe, Ashley M; Henderson, Brandon J; Richards, Christopher I (2017) Utilizing pHluorin-tagged Receptors to Monitor Subcellular Localization and Trafficking. J Vis Exp :|
|Peng, Hui; Geil Nickell, Chelsea R; Chen, Kevin Y et al. (2017) Increased expression of M1 and M2 phenotypic markers in isolated microglia after four-day binge alcohol exposure in male rats. Alcohol 62:29-40|
|Wang, Xiachang; Elshahawi, Sherif I; Cai, Wenlong et al. (2017) Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2. J Nat Prod 80:1141-1149|
|Zhang, Jianjun; Hughes, Ryan R; Saunders, Meredith A et al. (2017) Identification of Neuroprotective Spoxazomicin and Oxachelin Glycosides via Chemoenzymatic Glycosyl-Scanning. J Nat Prod 80:12-18|
|Fox-Loe, Ashley M; Moonschi, Faruk H; Richards, Christopher I (2017) Organelle-specific single-molecule imaging of ?4?2 nicotinic receptors reveals the effect of nicotine on receptor assembly and cell-surface trafficking. J Biol Chem 292:21159-21169|
|Chow, Jonathan J; Smith, Aaron P; Wilson, A George et al. (2017) Suboptimal choice in rats: Incentive salience attribution promotes maladaptive decision-making. Behav Brain Res 320:244-254|
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