This application requests a second renewal of five years of support for a successful interdisciplinary and translational training program in broad-based contemporary aspects of drug abuse research. Training the next generation of drug abuse researchers is critical to current and future public health challenges associated with drug addiction. The goal is to prepare trainees for productive and successful careers in drug abuse research. This program proposes to support 4 predoctoral and 2 postdoctoral trainees. We will vigorously recruit individuals from underrepresented minorities, disadvantaged backgrounds, and individuals with disabilities to increase diversity. This program provides a highly collaborative environment of interdisciplinary and translational training in drug abuse research. The 17 training faculty represent 7 academic units, have excellent training records, and will provide a rich interdisciplinary training environment. The program fosters the development of essential experimental and critical thinking skills, and provides the opportunity to gain an in depth understanding of and expertise in the interrelationships of the molecular/cellular aspects of receptors and signaling mechanisms involved in the neural and behavioral response to drugs of abuse and to become immersed in drug discovery and development in the pursuit of novel treatments for drug abuse. The overarching theme of the program is that drug addiction alters fundamental cellular and macromolecular processes resulting in long term changes in neural plasticity and behavior, which can be treated using pharmacotherapeutic intervention. The curriculum provides knowledge from physicochemical properties of molecules to structural biology, neurophysiology, neurochemistry, to animal and human behavior, with numerous opportunities for in depth study of focused areas of drug abuse research. The breadth of drug abuse research opportunities is enhanced by strong links to the University of Kentucky's (UK's) Center on Drug and Alcohol Research, the Center for Drug and Alcohol Research Translation, the Center for Clinical and Translational Science, the Center for Pharmaceutical Research and Innovation, the Laboratory on Human Behavioral Pharmacology and the Residential Research Facility. This program provides "value added" by serving as a linchpin to networking, interactions and collaborations with other trainees and training faculty focused on human behavioral and clinical aspects of drug abuse research and supported by a second T32 program directed by Dr. Craig Rush at UK. All positions in both T32 programs have been filled completely during the last funding period, indicative of the large number of promising trainees in drug abuse research at UK. UK provides solid infrastructure and institutional support, optimizing the training environment. The majority of program graduates continue to actively pursue drug abuse research and advance towards independent investigator status. In the upcoming funding period, we propose to continue our record of success and develop responsible and ethical drug abuse researchers, who will move the field of drug abuse forward.

Public Health Relevance

The goal of this training program is to prepare promising predoctoral and postdoctoral trainees for productive and successful careers in drug abuse research, a critical endeavor for current and future public health challenges associated with drug addiction. The program fosters the development of essential experimental and critical thinking skills and focused expertise on the interrelationships of cellular and molecular aspects of receptors and signaling mechanisms involved in the response to drugs of abuse within the context of drug discovery and development of novel treatments for drug abuse. Our program provides a highly collaborative environment of interdisciplinary and translational training in drug abuse research coupled with opportunities for networking and collaboration to advance our trainees towards independent investigator status in drug abuse research.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32DA016176-11
Application #
8667195
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Babecki, Beth
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Lexington
State
KY
Country
United States
Zip Code
40506
McClain, Justin A; Morris, Stephanie A; Marshall, S Alexander et al. (2014) Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence. Addict Biol 19:687-99
Yates, Justin R; Perry, Jennifer L; Meyer, Andrew C et al. (2014) Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure. Brain Res 1574:26-36
Sviripa, Vitaliy M; Zhang, Wen; Balia, Andrii G et al. (2014) 2',6'-Dihalostyrylanilines, pyridines, and pyrimidines for the inhibition of the catalytic subunit of methionine S-adenosyltransferase-2. J Med Chem 57:6083-91
Tajuddin, Nuzhath; Moon, Kwan-Hoon; Marshall, S Alex et al. (2014) Neuroinflammation and neurodegeneration in adult rat brain from binge ethanol exposure: abrogation by docosahexaenoic acid. PLoS One 9:e101223
Nickell, Justin R; Siripurapu, Kiran B; Vartak, Ashish et al. (2014) The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse. Adv Pharmacol 69:71-106
Geil, Chelsea R; Hayes, Dayna M; McClain, Justin A et al. (2014) Alcohol and adult hippocampal neurogenesis: promiscuous drug, wanton effects. Prog Neuropsychopharmacol Biol Psychiatry 54:103-13
Hofford, Rebecca S; Darna, Mahesh; Wilmouth, Carrie E et al. (2014) Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function. Behav Brain Res 270:151-8
Zheng, Guangrong; Horton, David B; Penthala, Narsimha Reddy et al. (2013) Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse. Medchemcomm 4:564-568
Liput, Daniel J; Hammell, Dana C; Stinchcomb, Audra L et al. (2013) Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder. Pharmacol Biochem Behav 111:120-7
Horton, David B; Nickell, Justin R; Zheng, Guangrong et al. (2013) GZ-793A, a lobelane analog, interacts with the vesicular monoamine transporter-2 to inhibit the effect of methamphetamine. J Neurochem 127:177-86

Showing the most recent 10 out of 44 publications