This proposal is for a training grant, """"""""Translational Research in Neurobiology of Disease"""""""", at the University of Minnesota. Trainees of this program are 1) graduate students who are pursuing a Ph.D. degree through the Graduate Program in Neuroscience, 2) postdoctoral fellows, and 3) clinical fellows. The challenge is to train basic neuroscientists who will have an appreciation for clinically relevant problems, and to train clinicians who have an appreciation of the fundamental principals of tools of basic science so that they can work together and accelerate the pace of translational neuroscience. The proposed training program funds predoctoral students during their second year in the Graduate Program in Neuroscience after they have committed to the translational neuroscience track. Postdoctoral fellows and clinical fellows can be funded at any point in their training, but must be committed to training in translational neuroscience. The training program is built around a core of didactic course work that includes a course in Neurobiology of Disease, and a Neuroscience Laboratory summer course for all trainees. These courses are designed to produce a dialog and interactions among basic and clinical neuroscientists to facilitate translational research. A group of over 37 trainers are proposed that reflects the diversity of research techniques in basic and clinical neuroscience, but with a thematic focus on neural degeneration and repair. Research interests range from molecular mechanisms underlying neurodegenerative disorders to therapies involving stem cells and recombinant DNA. Each trainer directs a productive research program and has demonstrated commitment to teaching and training. Representing 11 departments throughout the university, the trainers are united by their participation in the Graduate Program in Neuroscience and translational neuroscience research. The trainees will be provided with a strong, broad foundation in basic and clinical neurosciences upon which to build their translational research careers. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
1T32DA022616-01
Application #
7195356
Study Section
Special Emphasis Panel (ZDA1-KXN-G (08))
Program Officer
Babecki, Beth
Project Start
2006-09-26
Project End
2011-06-30
Budget Start
2006-09-26
Budget End
2007-06-30
Support Year
1
Fiscal Year
2006
Total Cost
$280,572
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Klank, Rebecca L; Decker Grunke, Stacy A; Bangasser, Benjamin L et al. (2017) Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level. Cell Rep 18:23-31
Hodel, Amanda S; Brumbaugh, Jane E; Morris, Alyssa R et al. (2016) Hot executive function following moderate-to-late preterm birth: altered delay discounting at 4 years of age. Dev Sci 19:221-34
Markovitz, Craig D; Hogan, Patrick S; Wesen, Kyle A et al. (2015) Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity. J Neural Eng 12:026006
San Miguel-Ruiz, José E; Letourneau, Paul C (2014) The role of Arp2/3 in growth cone actin dynamics and guidance is substrate dependent. J Neurosci 34:5895-908
Hunsberger, Holly C; Rudy, Carolyn C; Weitzner, Daniel S et al. (2014) Effect size of memory deficits in mice with adult-onset P301L tau expression. Behav Brain Res 272:181-95
Janson, Christopher G; Romanova, Liudmila G; Leone, Paola et al. (2014) Comparison of Endovascular and Intraventricular Gene Therapy With Adeno-Associated Virus-?-L-Iduronidase for Hurler Disease. Neurosurgery 74:99-111
Pisansky, Marc T; Wickham, Robert J; Su, Jianjun et al. (2013) Iron deficiency with or without anemia impairs prepulse inhibition of the startle reflex. Hippocampus 23:952-62
Markovitz, Craig D; Tang, Tien T; Lim, Hubert H (2013) Tonotopic and localized pathways from primary auditory cortex to the central nucleus of the inferior colliculus. Front Neural Circuits 7:77
Wolf, D A; Lenander, A W; Nan, Z et al. (2012) Increased longevity and metabolic correction following syngeneic BMT in a murine model of mucopolysaccharidosis type I. Bone Marrow Transplant 47:1235-40
Lambert, Aaron M; Bonkowsky, Joshua L; Masino, Mark A (2012) The conserved dopaminergic diencephalospinal tract mediates vertebrate locomotor development in zebrafish larvae. J Neurosci 32:13488-500

Showing the most recent 10 out of 19 publications