NISTP: NEUROIMAGING SCIENCES TRAINING PROGRAM This institutional grant requests funds for four postdoctoral positions for interdisciplinary training and research in neuroimaging. Two general classes of neuroimaging will be emphasized: radiotracer and nuclear magnetic resonance. The specific imaging methods are described by the following acronyms: PET (positron emission tomography, MRI (magnetic resonance imaging), including fMRI (functional magnetic resonance imaging) and DTI (diffusion tensor imaging), and MRS (magnetic resonance spectroscopy). These imaging methodologies offer real promise for the expanded clinical utility of neuroimaging in the diagnosis, treatment, and understanding of the pathophysiology of substance abuse and dependence. However, these new methodologies typically derive from complex, multidisciplinary sciences, which thereby create a challenging information barrier to their further development and application in medical practice. The purposes of the proposed program are the following: - Provide formal course training to postdoctoral fellows, with an emphasis on imaging and clinical research methodology, and instruction in their underlying multidisciplinary sciences. - Provide mentored training for fellows to apply these new methods to the interdisciplinary advance of our understanding of the function of the brain in health, substance abuse, and other psychiatric diseases. - Provide an integrated research experience for the fellows both in imaging applications and in methodology. All postdoctoral fellows will be expected to complete at least one research project with an applications mentor and one with a methodology mentor during their training period. The integration of training in methodology and imaging applications will be enhanced by the organization of this program as two interactive tracks of approximately equal size: Methodology and Application. We expect that the majority of postdoctoral fellows in the Methodology track will have Ph.D. degrees, and those in the Application track, primarily M.D. degrees or Ph.D. in neurosciences or behavioral sciences. Each fellow will have a primary and secondary faculty mentor to represent the two tracks.

Public Health Relevance

The Neuroimaging Sciences Training Program (NISTP) combines expertise in brain imaging technology with skill and knowledge in clinical applications for cross-training of postdoctoral trainees. The goal is to foster the development of interdisciplinary scientists who can comfortably apply complex imaging methods to understand the neuroscience of abuse and dependence of cocaine, smoking, alcohol, and other substances, as well as treatments for these problems.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
3T32DA022975-06A1S1
Application #
8861714
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Grant, Steven J
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Yale University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
City
New Haven
State
CT
Country
United States
Zip Code
06510
Kwon, Soo Hyun; Scheinost, Dustin; Vohr, Betty et al. (2016) Functional magnetic resonance connectivity studies in infants born preterm: suggestions of proximate and long-lasting changes in language organization. Dev Med Child Neurol 58 Suppl 4:28-34
Hillmer, A T; Esterlis, I; Gallezot, J D et al. (2016) Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (-)-[(18)F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain. Neuroimage 141:71-80
Blaine, Sara K; Milivojevic, Verica; Fox, Helen et al. (2016) Alcohol Effects on Stress Pathways: Impact on Craving and Relapse Risk. Can J Psychiatry 61:145-53
Rosenberg, Monica D; Finn, Emily S; Scheinost, Dustin et al. (2016) A neuromarker of sustained attention from whole-brain functional connectivity. Nat Neurosci 19:165-71
Hillmer, Ansel T; Zheng, Ming-Qiang; Li, Songye et al. (2016) PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates. Eur J Nucl Med Mol Imaging 43:537-47
Hillmer, Ansel T; Kloczynski, Tracy; Sandiego, Christine M et al. (2016) Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence. Alcohol Clin Exp Res 40:698-705
Rosenberg, Monica D; Zhang, Sheng; Hsu, Wei-Ting et al. (2016) Methylphenidate Modulates Functional Network Connectivity to Enhance Attention. J Neurosci 36:9547-57
Morie, Kristen P; Yip, Sarah W; Nich, Charla et al. (2016) Alexithymia and Addiction: A Review and Preliminary Data Suggesting Neurobiological Links to Reward/Loss Processing. Curr Addict Rep 3:239-248
Yip, Sarah W; DeVito, Elise E; Kober, Hedy et al. (2016) Anticipatory reward processing among cocaine-dependent individuals with and without concurrent methadone-maintenance treatment: Relationship to treatment response. Drug Alcohol Depend 166:134-42
Scheinost, Dustin; Tokoglu, Fuyuze; Shen, Xilin et al. (2016) Fluctuations in Global Brain Activity Are Associated With Changes in Whole-Brain Connectivity of Functional Networks. IEEE Trans Biomed Eng 63:2540-2549

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