This proposal seeks support for a pre- and postdoctoral training program on the Translational Neuroscience of Drug Addiction (TNDA) at UCLA (5-year competitive renewal, with positions for five predoctoral and three postdoctoral fellows). Four participating programs/departments host TNDA trainees: Brain Research Inst. (administering the Neuroscience Interdepartmental training program), Dept. Psychology, Dept. Molecular &Medical Pharmacology, Semel Institute of Neuroscience and Human Behavior, the first three offering doctoral training programs. TNDA has five aims: 1) to recruit and enroll highl qualified candidates who are interested in and committed to translational research in drug addiction (including vigorously recruiting from underrepresented populations);2) to provide hands-on experience at all stages of addiction research, including evidence-based hypothesis formation, experimental design, data acquisition and analyses, and preparing findings for oral and written presentation;3);to ensure that trainees develop expertise in a specific research area and supporting technology, while providing opportunities for trainees to acquire the breadth of knowledge needed to conduct translational research in drug addiction;4) to provide the resources, opportunities, and training that will enable trainees to use preliminary data in generating novel hypotheses and specific aims for NIH grant proposals, laying the groundwork for success in securing funding to pursue independent research;and 5) to provide career guidance so that trainees can successfully identify and secure professional positions allowing them to use the skills and knowledge obtained from TNDA. Accordingly, TNDA provides comprehensive interdisciplinary training through formal education and supervised research. Methodological issues and techniques are emphasized, and rigorous education in the ethics of conducting scientific research is provided. The participating mentors have active research programs at all levels of analysis - from cell and molecular biology and integrative study in animal models to brain imaging and cognitive neuroscience in humans. TNDA trainees have a primary project in a specific mentor's laboratory, but gain exposure to other areas of research through laboratory rotations, common core training, as well as by formal and informal interaction among TNDA faculty and leadership, including organized professional and social events for TNDA trainees. The Program Director and participating faculty have excellent records in research and past mentorship and strive to provide trainees with the knowledge needed to plan and conduct integrative, translational studies.

Public Health Relevance

By its own right and through its contributions to medical disorders, violence, crime and accidents, drug abuse is a major determinant of mortality and societal burden. Despite high public health significance of the problem, treatment and prevention of drug abuse are limited by lack of knowledge regarding its neural bases. The UCLA Training Program on the Translational Neuroscience of Drug Addiction (TNDA) provides multidisciplinary training that spans the fundamental bases of addiction from the genome to neural phenotypes and ultimately the syndrome of addiction, with particular strength in molecular and cellular neurobiology, brain imaging, and behavioral neuroscience.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Institutional National Research Service Award (T32)
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Study Section
AIDS Behavioral Research Subcommittee (NIDA)
Program Officer
Kautz, Mary A
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University of California Los Angeles
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Los Angeles
United States
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Kohno, Milky; Nurmi, Erika L; Laughlin, Christopher P et al. (2016) Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making. Neuropsychopharmacology 41:695-703
Robertson, Chelsea L; Ishibashi, Kenji; Chudzynski, Joy et al. (2016) Effect of Exercise Training on Striatal Dopamine D2/D3 Receptors in Methamphetamine Users during Behavioral Treatment. Neuropsychopharmacology 41:1629-36
Cservenka, Anita (2016) Neurobiological phenotypes associated with a family history of alcoholism. Drug Alcohol Depend 158:8-21
Okita, Kyoji; Ghahremani, Dara G; Payer, Doris E et al. (2016) Relationship of Alexithymia Ratings to Dopamine D2-type Receptors in Anterior Cingulate and Insula of Healthy Control Subjects but Not Methamphetamine-Dependent Individuals. Int J Neuropsychopharmacol 19:
Okita, Kyoji; Ghahremani, Dara G; Payer, Doris E et al. (2016) Emotion dysregulation and amygdala dopamine D2-type receptor availability in methamphetamine users. Drug Alcohol Depend 161:163-70
Okita, Kyoji; Mandelkern, Mark A; London, Edythe D (2016) Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence. Int J Neuropsychopharmacol 19:
Mendez, Ian A; Maidment, Nigel T; Murphy, Niall P (2016) Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice. Behav Pharmacol 27:516-27
Perusini, Jennifer N; Meyer, Edward M; Long, Virginia A et al. (2016) Induction and Expression of Fear Sensitization Caused by Acute Traumatic Stress. Neuropsychopharmacology 41:45-57
Thompson, Andrew B; Stolyarova, Alexandra; Ying, Zhe et al. (2015) Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum. Neuropharmacology 99:658-64
Stolyarova, Alexandra; Thompson, Andrew B; Barrientos, Ruth M et al. (2015) Reductions in frontocortical cytokine levels are associated with long-lasting alterations in reward valuation after methamphetamine. Neuropsychopharmacology 40:1234-42

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