Interdisciplinary clinical research on the combined effects of substance abuse and HIV infection on the central nervous system (CNS) is of considerable relevance to public health initiatives. However, there are presently few laboratories conducting such research and (aside from ours) no current training programs dedicated to preparing the next generation of investigators in this critical area. In its first funding period or Ruth L Kirschstein National Research Service Award Institutional Training Grant (NRSA T32) entitled, Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN) has brought together a talented and culturally diverse cohort of pre- and post-doctoral trainees, an accomplished multidisciplinary team of mentors, an effective administrative structure, and a broad array of academic resources, with what is now a proven track record in preparing the Nation's next generation of academics to lead the field of substance abuse and neuroAIDS. The 9 students and fellows mentored during the current funding period have achieved remarkable productivity: In total, they have published nearly 60 manuscripts in the scientific literature (24 s first author) and have made over 70 presentations in scientific conferences (28 first authored); they also have successfully competed for 5 extramural and 3 intramural grants to further their research; and 3 have obtained new faculty or research scientist positions. Accordingly, we propose a renewal of TRAIN to build on these successes for the future of the field.
Its aim i s to prepare a steady state of three pre-doctoral and two post-doctoral trainees in clinical neuropsychology for multidisciplinary academic careers focused on the CNS effects of substance abuse and HIV infection, with a new theme on aging with these comorbid conditions. TRAIN emphasizes research training in three primary, interrelated CNS outcomes, which were selected for their scientific and

Public Health Relevance

Substance abuse and HIV infection are highly prevalent, commonly co-occur, and have adverse effects on brain structure and function, but too few scientists are properly trained to study these important phenomena. The initial funding of our 'Training on Addictions and Interdisciplinary NeuroAIDS (TRAIN)' program has been highly successful in recruiting and preparing nine remarkably productive and culturally diverse pre- and post-doctoral scholars to conduct cutting edge research in this field. In seeking a renewal of TRAIN we propose building on this success in preparing future leaders in the field of substance abuse and neuroAIDS, with a new emphasis on a potential for accelerated brain aging with these conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Institutional National Research Service Award (T32)
Project #
5T32DA031098-08
Application #
9479111
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Lin, Yu
Project Start
2011-07-01
Project End
2021-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
8
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Faytell, Marika Pers; Doyle, Katie; Naar-King, Sylvie et al. (2018) Calendaring and alarms can improve naturalistic time-based prospective memory for youth infected with HIV. Neuropsychol Rehabil 28:1038-1051
Kordovski, Victoria M; Woods, Steven Paul; Verduzco, Marizela et al. (2017) The effects of aging and HIV disease on employment status and functioning. Rehabil Psychol 62:591-599
Faytell, Marika P; Doyle, Katie L; Naar-King, Sylvie et al. (2017) Visualisation of future task performance improves naturalistic prospective memory for some younger adults living with HIV disease. Neuropsychol Rehabil 27:1142-1155
Moore, Raeanne C; Paolillo, Emily W; Heaton, Anne et al. (2017) Clinical utility of the UCSD Performance-Based Skills Assessment-Brief (UPSA-B) in adults living with HIV: Associations with neuropsychological impairment and patient-reported everyday functioning difficulties. PLoS One 12:e0183614
Paolillo, Emily W; Gongvatana, Assawin; Umlauf, Anya et al. (2017) At-Risk Alcohol Use is Associated with Antiretroviral Treatment Nonadherence Among Adults Living with HIV/AIDS. Alcohol Clin Exp Res 41:1518-1525
Obermeit, Lisa C; Beltran, Jessica; Casaletto, Kaitlin B et al. (2017) Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining ""symptomatic"" versus ""asymptomatic"" HAND. J Neurovirol 23:67-78
Fazeli, P L; Casaletto, K B; Paolillo, E et al. (2017) Screening for neurocognitive impairment in HIV-positive adults aged 50 years and older: Montreal Cognitive Assessment relates to self-reported and clinician-rated everyday functioning. J Clin Exp Neuropsychol 39:842-853
Montoya, Jessica L; Iudicello, Jennifer; Oppenheim, Hannah A et al. (2017) Coagulation imbalance and neurocognitive functioning in older HIV-positive adults on suppressive antiretroviral therapy. AIDS 31:787-795
Flores, Ilse; Casaletto, Kaitlin B; Marquine, Maria J et al. (2017) Performance of Hispanics and Non-Hispanic Whites on the NIH Toolbox Cognition Battery: the roles of ethnicity and language backgrounds. Clin Neuropsychol 31:783-797

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