This application requests continued support for a research training program in Otolaryngology to provide two-year basic and clinical research training opportunities for physicians pursuing an academic career in Otolaryngology-Head and Neck Surgery. Research training in neurosciences, molecular genetics, molecular biology, and epidemiology promotes the long-term goal of increasing the number and quality of independent clinical investigators studying the underlying mechanisms, diagnostic criteria, and therapeutic approaches of the impaired auditory and other communicative systems. A multidisciplinary educational environment is created through the interaction of over thirty clinicians and basic scientists from the departments and programs of Otolaryngology-Head and Neck Surgery, Hearing Sciences, Speech Science, Neuroscience, Internal Medicine, Pediatric Genetics, Microbiology, Molecular Biology, and The College of Public Health. A wide assortment of research training opportunities are available, ranging from basic research in electrophysiology and molecular biology of the auditory system, neuroanatomy, neurolaryngology, molecular genetics of deafness, and molecular biology of craniofacial deformities to clinical investigations involving epidemiologic study of hearing loss, craniofacial deformities, head and neck cancer, speech disorders, and clinical trials study of hearing loss, craniofacial deformities, head and neck cancer, speech disorders and clinical trials methodology. Trainees will be enrolled in didactic courses in their area of interest throughout the two-year training period. The application requests two postgraduate training positions a year (ten over five years) for physicians completing at least one year of clinical training. Trainees will devote 100% of their effort to research training for two consecutive years, to be followed by a four-year clinical residency in Otolaryngology-Head and Neck Surgery. The proposed research training program will expand the research training opportunities available to future academic otolaryngologists, foster interaction among clinical and basic scientists, and provide physicians with tools to become comprehensive independent clinical research scientists.
Training physician scientists in communicative disorders basic research will expand translational research that will have an impact on deliver of care, as well as advance the treatment of communicative disorders.
|Shibata, Seiji B; Ranum, Paul T; Moteki, Hideaki et al. (2016) RNA Interference Prevents Autosomal-Dominant Hearing Loss. Am J Hum Genet 98:1101-13|
|Hua, Xiaoyang; Naselsky, Warren C; Jania, Corey M et al. (2016) Mast Cell Deficiency Limits the Development of Chronic Rhinosinusitis in Mice. Ann Otol Rhinol Laryngol 125:290-6|
|Ahmad, Iram; Fernando, Augusta; Gurgel, Richard et al. (2015) Merlin status regulates p75(NTR) expression and apoptotic signaling in Schwann cells following nerve injury. Neurobiol Dis 82:114-22|
|Kopelovich, Jonathan C; Reiss, Lina A J; Etler, Christine P et al. (2015) Hearing Loss After Activation of Hearing Preservation Cochlear Implants Might Be Related to Afferent Cochlear Innervation Injury. Otol Neurotol 36:1035-44|
|Kopelovich, Jonathan C; Robinson, Barbara K; Soken, Hakan et al. (2015) Acoustic Hearing After Murine Cochlear Implantation: Effects of Trauma and Implant Type. Ann Otol Rhinol Laryngol 124:931-9|
|Ahmad, Iram; Yue, Wei Ying; Fernando, Augusta et al. (2014) p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor ÎºB. Glia 62:1699-712|
|Schularick, Nathan M; Clark, J Jason; Hansen, Marlan R (2014) Primary culture of human vestibular schwannomas. J Vis Exp :|
|Kopelovich, Jonathan C; Reiss, Lina A J; Oleson, Jacob J et al. (2014) Risk factors for loss of ipsilateral residual hearing after hybrid cochlear implantation. Otol Neurotol 35:1403-8|
|Taylor, Kyle R; Deluca, Adam P; Shearer, A Eliot et al. (2013) AudioGene: predicting hearing loss genotypes from phenotypes to guide genetic screening. Hum Mutat 34:539-45|
|Kopelovich, Jonathan C; Cagaanan, Alain P; Miller, Charles A et al. (2013) Intracochlear electrical stimulation suppresses apoptotic signaling in rat spiral ganglion neurons after deafening in vivo. Otolaryngol Head Neck Surg 149:745-52|
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