This proposal is a competing continuation of a currently funded Kirschstein-NRSA T-32 training award in Tissue Engineering and Regeneration (DE07057-35). A primary goal of modern dentistry and medicine is to predictably restore tissues and organs that have been lost due to pathology, trauma, or congenital abnormalities. Recent advances in understanding the factors, cells and mechanisms regulating tissue function, coupled with the new materials science and other engineering technologies available for delivery of agents to sites of repair have provided the tools required for researchers to focus on designing "tissue engineered products" for therapeutic use. These efforts require an interdisciplinary approach, with involvement of biomedical scientists, engineers, and clinical researchers. TEAM (Tissue Engineering at Michigan) a Training Program in tissue engineering and regeneration was developed with recognition of the need to train individuals in these various disciplines and of the need to ensure active exchange of ideas between individuals across disciplines. The primary objective of this training program is to provide an interdisciplinary research-intensive environment for individuals who wish to pursue careers in the Oral Sciences, with a focus in the area of restoration of oral-craniofacial tissues. This comprehensive Program has built-in flexibility, providing intensive training opportunities in both basic biomedical and clinical science. Moreover, through "Core" programs opportunities are available for cross- disciplinary and interprofessional research interactions. Specific trainee programs planned include: 1). DSTP;2) traditional Ph.D.;and 3) Post-doctoral Fellow. Trainees will be selected based on strong academic records, recommendation letters, and commitment to a research career focused in oral science, with an emphasis on tissue engineering and regeneration. Specific efforts will be made to recruit individuals from underrepresented racial and ethnic backgrounds. This is a multidisciplinary program that spans across departmental and school boundaries, thus providing the student the flexibility to choose mentors across departments and campuses. TEAM involves three schools on campus, the School of Dentistry, Medical School, and College of Engineering, where in addition to the "Core" curriculum in "Tissue Engineering and Regeneration", didactic training will be provided through departments at these schools. All trainees will receive formal instruction in responsible conduct of research. The University of Michigan recognizes the importance of quality training programs and is committed to training oral scientists as independent researchers and life-long learners.

Public Health Relevance

A primary goal of modern dentistry and medicine is to predictably restore tissues and organs that have been lost due to pathology, trauma, or congenital abnormalities. Recent advances in understanding the factors, cells and mechanisms regulating tissue function, coupled with the new materials science and other engineering technologies available for delivery of agents to sites of repair have provided the tools required for researchers to focus on designing tissue engineered products for therapeutic use. These efforts require an interdisciplinary approach, with involvement of biomedical scientists, engineers, and clinical researchers. The central goal of this Training Program in tissue engineering and regeneration is to provide an interdisciplinary research-intensive environment for individuals who wish to pursue careers in the Oral Sciences, with a focus in the area of restoration of oral-craniofacial tissues. This comprehensive Program involves the School of Dentistry, Medical School, and College of Engineering, and spans across departmental and school boundaries, providing intensive training opportunities in both basic biomedical and clinical science. Support for 1) DDS/Ph.D. dual degree (5), 2) traditional Ph.D. (7) and 3) Post-doctoral Fellow trainees (5) is requested.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
5T32DE007057-37
Application #
8501409
Study Section
Special Emphasis Panel (ZDE1-RK (07))
Program Officer
King, Lynn M
Project Start
1976-07-01
Project End
2017-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
37
Fiscal Year
2013
Total Cost
$715,550
Indirect Cost
$40,274
Name
University of Michigan Ann Arbor
Department
Biology
Type
Schools of Dentistry
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
McNerny, Erin M B; Gong, Bo; Morris, Michael D et al. (2015) Bone fracture toughness and strength correlate with collagen cross-link maturity in a dose-controlled lathyrism mouse model. J Bone Miner Res 30:455-64
Martin-Saavedra, Francisco M; Cebrian, Virginia; Gomez, Leyre et al. (2014) Temporal and spatial patterning of transgene expression by near-infrared irradiation. Biomaterials 35:8134-43
Mohiti-Asli, Mahsa; Pourdeyhimi, Behnam; Loboa, Elizabeth G (2014) Skin tissue engineering for the infected wound site: biodegradable PLA nanofibers and a novel approach for silver ion release evaluated in a 3D coculture system of keratinocytes and Staphylococcus aureus. Tissue Eng Part C Methods 20:790-7
Walters, B D; Stegemann, J P (2014) Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales. Acta Biomater 10:1488-501
Wilson, Christopher G; Martín-Saavedra, Francisco M; Padilla, Frédéric et al. (2014) Patterning expression of regenerative growth factors using high intensity focused ultrasound. Tissue Eng Part C Methods 20:769-79
Velkey, J Matthew; O'Shea, K Sue (2013) Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. Dev Dyn 242:230-53
Novince, Chad M; Entezami, Payam; Wilson, Christopher G et al. (2013) Impact of proteoglycan-4 and parathyroid hormone on articular cartilage. J Orthop Res 31:183-90
Martin-Saavedra, Francisco M; Wilson, Christopher G; Voellmy, Richard et al. (2013) Spatiotemporal control of vascular endothelial growth factor expression using a heat-shock-activated, rapamycin-dependent gene switch. Hum Gene Ther Methods 24:160-70
Wilson, C G; Martin-Saavedra, F M; Vilaboa, N et al. (2013) Advanced BMP gene therapies for temporal and spatial control of bone regeneration. J Dent Res 92:409-17
Zhang, Zhanpeng; Gupte, Melanie J; Ma, Peter X (2013) Biomaterials and stem cells for tissue engineering. Expert Opin Biol Ther 13:527-40

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