This is a proposal for the continuation of the Institutional Training Program in Skeletal, Craniofacial and Oral Biology (SCOB) at the University of Connecticut School of Dental Medicine. It is intended to help meet the substantial need for dental research scholars in the United States. The program has produced and will continue to produce dental scholars to meet the growing needs of academic dentistry, who are competent as clinicians and independent as scientists, who are able to initiate and maintain funded research programs, and who are prepared for the evolution of their research into new directions. The four major tracks of the training program are DMD/PhD (7-8 yrs; 10 present trainees; 10 additional trainees requested), PhD (4-5 yrs; 0 present trainees; 0 additional trainees requested at this time), postdoctoral research (2-3 yrs; 3 present trainees; 6 additional trainees requested) and short-term dental student research (3 mos; 12 trainees/year; 60 trainees requested). We will be training individuals from a broad spectrum of experiences from completion of BS/BA degrees to those who have completed PhD and/or dental residency training. Degree program tracks will focus on basic biological problems related to dental, skeletal, craniofacial and oral biology in health and disease. The postdoctoral training track will include translational and behavioral research in addition to the above areas. A core curriculum which integrates different disciplines and levels of training and expertise exposes trainees to the diversity and complexity of the biology and sociology of oral diseases. The Health Center has a dynamic group of faculty in SCOB, with highly successful collaborations among faculty throughout the Schools of Dental Medicine and Medicine. The Biomedical Science PhD program graduate faculty and active institutional research centers and clinical signature programs provide laboratory, translational and patient oriented research opportunities that enable a diversified training environment for the program tracks, allow flexibility for the individual needs of trainees, and ensure successful progress through the tracks. The institution has vigorous trainee recruitment programs; several are directed towards under- represented minority candidates. We will continue to provide training that is tailored to each candidate, while maintaining a focus on skeletal, craniofacial and oral biology through symposia, seminars, courses, clinical research centers and collaborative research activities which are integrated both within individual tracks and amongst all the tracks of the program. Oral health is critical to a good quality of life. The quality of dental care delivered nationwide is dependent on continuing advancement in our understanding of oral and craniofacial diseases and the application of this understanding to patient care. Thus, training of outstanding dental and craniofacial scientists is critical to the health and quality of life of the American public. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
2T32DE007302-11
Application #
7123657
Study Section
Special Emphasis Panel (ZDE1-LK (28))
Program Officer
Hardwick, Kevin S
Project Start
1996-08-01
Project End
2011-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
11
Fiscal Year
2006
Total Cost
$618,328
Indirect Cost
Name
University of Connecticut
Department
Dentistry
Type
Schools of Dentistry
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
Zinn, Vina Z; Khatri, Aditi; Mednieks, Maija I et al. (2015) Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells. Eur J Oral Sci 123:140-8
Chen, I-P; Tadinada, A; Dutra, E H et al. (2014) Dental Anomalies Associated with Craniometaphyseal Dysplasia. J Dent Res 93:553-8
Costa-Guda, Jessica; Imanishi, Yasuo; Palanisamy, Nallasivam et al. (2013) Allelic imbalance in sporadic parathyroid carcinoma and evidence for its de novo origins. Endocrine 44:489-95
Dutra, E H; Chen, I-P; Reichenberger, E J (2013) Dental abnormalities in a mouse model for craniometaphyseal dysplasia. J Dent Res 92:173-9
Liu, Yaling; Strecker, Sara; Wang, Liping et al. (2013) Osterix-cre labeled progenitor cells contribute to the formation and maintenance of the bone marrow stroma. PLoS One 8:e71318
Strecker, Sara; Fu, Yu; Liu, Yaling et al. (2013) Generation and characterization of Osterix-Cherry reporter mice. Genesis 51:246-58
Costa-Guda, Jessica; Soong, Chen-Pang; Parekh, Vaishali I et al. (2013) Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas. Horm Cancer 4:301-7
Huling, Laura B; Baccaglini, Lorena; Choquette, Linda et al. (2012) Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis. J Oral Pathol Med 41:149-52
Lurie, Alan; Tosoni, Guilherme M; Tsimikas, John et al. (2012) Recursive hierarchic segmentation analysis of bone mineral density changes on digital panoramic images. Oral Surg Oral Med Oral Pathol Oral Radiol 113:549-58.e1
Dutra, E H; Chen, I-P; McGregor, T L et al. (2012) Two novel large ANKH deletion mutations in sporadic cases with craniometaphyseal dysplasia. Clin Genet 81:93-5

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