This is a new application from the College of Dental Medicine at the Medical University of South Carolina (MUSC) that requests (1) continued NIDCR support for a summer research training program for dental students with a proven record of success;(2) support for a Dual Degree (DMD/PhD) Program established with institutional funds, which also has a proven record of success;and (3) support for a new Postdoctoral Research Program that will address a gap in a comprehensive roster of oral and craniofacial research training opportunities at MUSC. The full complement of research training options is enhanced by other NIH and institutionally supported programs at MUSC that offer research career development tracks for junior dental faculty (notably the NCRR P20 """"""""COBRE"""""""" and NIDCR U24 awards) and an NIH Roadmap T32 award for predoctoral training in clinical research. Included in this proposal is a Progress Report summarizing relevant research training achievements to date as proof of principle and documentation. The overarching objective of the proposed Dental Research Training Program (DRTP) is to train an interdisciplinary cadre of talented investigators for careers in dental, oral and craniofacial science who will become the next generation of dental school faculty and provide academic leadership in the nation's dental, oral and craniofacial research programs. Mentoring and training activities are thematically grouped in five strategic areas of research focus: (i) infection and immunity, (ii) oral and systemic health, (iii) oral cancer, (iv) regenerative medicine/bioengineering, and (v) proteomics. Integrative training components, including an Oral Health Journal Club, Seminar Series, and Student Research Day, provide a framework for all trainees to interact, collaborate, and work together during their training experience. The proposed program benefits from the excellent administrative support and institutional commitment already in place and operating effectively in the Center for Oral Health Research. An integrated multi-year evaluation plan will be used to measure the extent to which the program goals and objectives are met.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Institutional National Research Service Award (T32)
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Study Section
Special Emphasis Panel (ZDE1-LK (28))
Program Officer
Hardwick, Kevin S
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Medical University of South Carolina
Schools of Dentistry
United States
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Lee, Jaden S; Yilmaz, Özlem (2018) Unfolding Role of a Danger Molecule Adenosine Signaling in Modulation of Microbial Infection and Host Cell Response. Int J Mol Sci 19:
Wright, Gregory J; Coombs, Matthew C; Wu, Yongren et al. (2018) Electrical Conductivity Method to Determine Sexual Dimorphisms in Human Temporomandibular Disc Fixed Charge Density. Ann Biomed Eng 46:310-317
Howie, R Nicole; Durham, Emily; Oakes, Brayden et al. (2018) Testing a novel nanofibre scaffold for utility in bone tissue regeneration. J Tissue Eng Regen Med 12:2055-2066
Howie, R Nicole; Herberg, Samuel; Durham, Emily et al. (2018) Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model. Int J Oral Sci 10:25
Lee, Kyulim; Roberts, JoAnn S; Choi, Chul Hee et al. (2018) Porphyromonas gingivalis traffics into endoplasmic reticulum-rich-autophagosomes for successful survival in human gingival epithelial cells. Virulence 9:845-859
Cisewski, Sarah E; Wu, Yongren; Damon, Brooke J et al. (2018) Comparison of Oxygen Consumption Rates of Nondegenerate and Degenerate Human Intervertebral Disc Cells. Spine (Phila Pa 1976) 43:E60-E67
Durham, Emily L; Howie, R Nicole; Hall, SarahRose et al. (2018) Optimizing bone wound healing using BMP2 with absorbable collagen sponge and Talymed nanofiber scaffold. J Transl Med 16:321
She, Xin; Wei, Feng; Damon, Brooke J et al. (2018) Three-dimensional temporomandibular joint muscle attachment morphometry and its impacts on musculoskeletal modeling. J Biomech 79:119-128
Lee, Jungnam; Roberts, JoAnn S; Atanasova, Kalina R et al. (2018) A novel kinase function of a nucleoside-diphosphate-kinase homologue in Porphyromonas gingivalis is critical in subversion of host cell apoptosis by targeting heat-shock protein 27. Cell Microbiol 20:e12825
Thomas, Raquela J; Oleinik, Natalia; Panneer Selvam, Shanmugam et al. (2017) HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. EMBO Mol Med 9:1030-1051

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