This is a competing renewal application for a T32 grant that supports Training in Craniofacial and Oral Health Research (T-COHR), an integrated research training program based in the College of Dental Medicine at the Medical University of South Carolina (MUSC). The overarching objective of T-COHR is to foster the development of clinician scientists and scientists focused on oral, dental and craniofacial research. T-COHR provides a strong curriculum and thematic research experiences in an integrative framework that emphasizes mentoring, scientific advancement, academic career development, grantsmanship and productivity. This application requests: (1) continued support for the Dental Scientist Training Program (DSTP), offering a consolidated DMD/PhD degree pathway;(2) continued support for predoctoral research training leading to the PhD degree in biomedical sciences or bioengineering with applications to oral/craniofacial health;and (3) continued support for postdoctoral research training for dentist-scientists and/or non-clinician PhD scientists in basic, translational or bioengineering sciences important to dental, oral or craniofacial health. T-COHR is an integral part of the Center for Oral Health Research (COHR), a University Center of Research Excellence in the College of Dental Medicine that engages faculty and trainees in other disciplines and departments in the Colleges of Medicine, Graduate Studies, Nursing and Dental Medicine at MUSC, the Department of Bioengineering at Clemson University, and the Hollings Cancer Center at MUSC. T-COHR mentoring and training activities are thematically grouped in 4 strategic areas of research focus: (i) basic and translational science related to oral infection and inflammation, (ii) oral pharyngeal cancer biology and cancer immunology, (iii) bioengineering/biomechanics and craniofacial regeneration, and (iv) bio-behavioral factors related to oral and systemic health in special populations. Integrative activities include a College of Medicine Scholars Day, COHR Monthly Meetings and Symposia, an Oral Health Journal Club and Oral Health Seminar Series, as well as didactic instruction through courses designed specifically for T-COHR trainees. T-COHR benefits from excellent administrative support and institutional commitment that provide sustainability to the Center for Oral Health Research. T-COHR includes an integrated multi-year evaluation plan to measure the extent to which program goals and objectives are met.

Public Health Relevance

In the United States, there remains a critical need for well-trained investigators in dental, oral and craniofacial research. This training grant application supports Training in Craniofacial and Oral Health Research (T-COHR), an integrated program based in the College of Dental Medicine at the Medical University of South Carolina (MUSC) to help train the next generation of clinician scientists and scientists engaged in dental, oral and craniofacial research. Research training will be in the areas of oral infection and inflammation, oral cancer, bioengineering and craniofacial regeneration, and bio-behavioral factors related to oral health in special populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Institutional National Research Service Award (T32)
Project #
2T32DE017551-06
Application #
8152015
Study Section
Special Emphasis Panel (ZDE1-RW (09))
Program Officer
King, Lynn M
Project Start
2006-07-01
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
6
Fiscal Year
2011
Total Cost
$530,113
Indirect Cost
Name
Medical University of South Carolina
Department
Internal Medicine/Medicine
Type
Schools of Dentistry
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Roberts, JoAnn S; Atanasova, Kalina R; Lee, Jungnam et al. (2017) Opportunistic Pathogen Porphyromonas gingivalis Modulates Danger Signal ATP-Mediated Antibacterial NOX2 Pathways in Primary Epithelial Cells. Front Cell Infect Microbiol 7:291
Rosset, Emilie Moore; Trombetta-eSilva, Jessica; Hepfer, Glenn et al. (2017) SPARC and the N-propeptide of collagen I influence fibroblast proliferation and collagen assembly in the periodontal ligament. PLoS One 12:e0173209
Alexander-Bryant, Angela A; Zhang, Haiwen; Attaway, Christopher C et al. (2017) Dual peptide-mediated targeted delivery of bioactive siRNAs to oral cancer cells in vivo. Oral Oncol 72:123-131
Coombs, M C; Petersen, J M; Wright, G J et al. (2017) Structure-Function Relationships of Temporomandibular Retrodiscal Tissue. J Dent Res 96:647-653
Novince, Chad M; Whittow, Carolyn R; Aartun, Johannes D et al. (2017) Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health. Sci Rep 7:5747
Durham, Emily; Howie, R Nicole; Parsons, Trish et al. (2017) Thyroxine Exposure Effects on the Cranial Base. Calcif Tissue Int 101:300-311
Wu, Yongren; Cisewski, Sarah E; Sun, Yi et al. (2017) Quantifying Baseline Fixed Charge Density in Healthy Human Cartilage Endplate: A Two-point Electrical Conductivity Method. Spine (Phila Pa 1976) 42:E1002-E1009
Lee, Jungnam; Roberts, JoAnn S; Atanasova, Kalina R et al. (2017) Human Primary Epithelial Cells Acquire an Epithelial-Mesenchymal-Transition Phenotype during Long-Term Infection by the Oral Opportunistic Pathogen, Porphyromonas gingivalis. Front Cell Infect Microbiol 7:493
Wei, F; Van Horn, M H; Coombs, M C et al. (2017) A pilot study of nocturnal temporalis muscle activity in TMD diagnostic groups of women. J Oral Rehabil 44:517-525
Atanasova, Kalina; Lee, Jungnam; Roberts, JoAnn et al. (2016) Nucleoside-Diphosphate-Kinase of P. gingivalis is Secreted from Epithelial Cells In the Absence of a Leader Sequence Through a Pannexin-1 Interactome. Sci Rep 6:37643

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