This application is a competing renewal application for years 37-41 for this Training Grant in Diabetes and Endocrinology. It was the first, and remains the longest-running, T-32 grant at the University of Pittsburgh School of Medicine. The goals of the application are: A. To attract outstanding MD and PhD postdoctoral trainees with authentic academic interests and potential B. To pair them with similarly outstanding research training faculty to serve as mentors C. To provide a venue for outstanding training and mentoring in diabetes, obesity, bone and mineral, osteoporosis, endocrine epidemiology, as well as basic cellular and molecular endocrinology research D. To eliminate the barriers between clinical, basic and translational research in Endocrinology E. To support the trainee's and mentor's needs in providing this outstanding training F. To provide a supportive and highly enriching didactic environment in which to receive this training G. To help the trainees transition to junior faculty positions H. To adequately protect MD trainees from clinical responsibilities while receiving research training I. To provide opportunities for research training to all members of underrepresented ethnic, disadvantaged and disabled groups J. To provide formal, documented instruction in research integrity, responsible conduct of research as well as all other areas of research conduct and compliance In the last round of funding, the program has shown a strong record of meeting all of these goals, with 58- 74% of graduates in the past 10 years now serving in academic positions, depending on how rigorously """"""""academic"""""""" is defined

Public Health Relevance

This Training Grant helps to replenish the supply of academic specialists, both MD and PhD, in topical areas of national health priorities, such as diabetes, obesity, osteoporosis, and women's health. It supports a high quality program, and its quality is continuing to further improve with each year, by every objective measure. It has been successful in training, excellent candidates, with half to three quarters of trainees in the past 10 years remaining in academia.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007052-37
Application #
7850308
Study Section
Special Emphasis Panel (ZDK1-GRB-W (J3))
Program Officer
Castle, Arthur
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
37
Fiscal Year
2010
Total Cost
$252,093
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Frahm, Krystle A; Waldman, Jacob K; Luthra, Soumya et al. (2017) A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells. Mol Cell Endocrinol :
Costa, Diana K; Huckestein, Brydie R; Edmunds, Lia R et al. (2016) Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice. Am J Physiol Endocrinol Metab 311:E105-16
Bannwarth, Sylvie; Berg-Alonso, Laetitia; Augé, Gaëlle et al. (2016) Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice. Mitochondrion 30:126-37
Wang, Huabo; Lu, Jie; Edmunds, Lia R et al. (2016) Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma. J Biol Chem 291:26241-26251
Belmonte, Frances R; Martin, James L; Frescura, Kristin et al. (2016) Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions. Sci Rep 6:25186
Frahm, Krystle A; Peffer, Melanie E; Zhang, Janie Y et al. (2016) Research Resource: The Dexamethasone Transcriptome in Hypothalamic Embryonic Neural Stem Cells. Mol Endocrinol 30:144-54
Liu, Teresa T; Grubisha, Melanie J; Frahm, Krystle A et al. (2016) Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor ? (ER?) Response to 5?-Reductase Inhibition in Prostate Epithelial Cells. J Biol Chem 291:14747-60
Rachakonda, Vikrant P; Reeves, Valerie L; Aljammal, Jules et al. (2015) Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity. Obesity (Silver Spring) 23:965-72
Lyons, Sarah K; Helgeson, Vicki S; Witchel, Selma F et al. (2015) PHYSICIANS' SELF-PERCEPTIONS OF CARE FOR EMERGING ADULTS WITH TYPE 1 DIABETES. Endocr Pract 21:903-9
Dubé, John J; Sitnick, Mitch T; Schoiswohl, Gabriele et al. (2015) Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice. Am J Physiol Endocrinol Metab 308:E879-90

Showing the most recent 10 out of 54 publications