This is a request for the seventh consecutive renewal of a T-32 award for training postdoctoral candidates in research to prepare them for leadership roles in academic gastroenterology. TRAINING RECORD: Over the last ten years, a total of 19 trainees have completed training: 14/19 trainees pursued a research oriented career after training and six trainees have received NIH funding. One minority and seven women candidates have graduated from this program. ADMINISTRATION: Dr. Arun Sanyal, a senior funded investigator and the director of the division of Gastroenterology at VCU Medical Center, is the director of the T-32 program. He is supported by the executive committee that advises him and helps execute the training program, and a steering committee that evaluates the overall direction of the program. PROGRAM ORGANIZATION: There are four major participating units: (1) Enteric neuro-muscular and epithelial biology, (2) Hepatobiliary lipids, (3) Gl Cancer and (4) Splanchnic and hepatic blood flow groups. There are a total of 23 participating faculty who are all independently funded with annual research base (directs costs) of $15.5 million. Over the last ten years, the faculty have published 957 medline [sic]-indexed papers;the average impact factor of papers published by members of the division of gastroenterology is 12.42. There are extensive collaborative networks between the faculty members who also frequently co-mentor trainees. TRAINEES: This program accepts trainees who are either board eligible in internal medicine (66-75% of trainees) and/or have a PhD in a biomedical field (25-33% of trainees). Special efforts are made annually to recruit minority candidates. TRAINING PROGRAMS: Trainess [sic] will have the opportunity to train in one of the participating unit laboratories. Each unit has been structured to be seamlessly integrated with institutional core facilities so that translational research can be performed at the highest level. A comprehensive training program that includes didactic lectures, research seminars, technology seminars, journal clubs, cell biology courses and hands on training in research is provided. Mandatory training in research integrity and grant writing are also provided. Each trainee is under the direct supervision of one mentor sometimes with additional content comentors. The need for research training, the strong record of this program and continued research strengths of this prgroam [sic] form a basis for this application for renewal of this T-32 training grant.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
3T32DK007150-33S1
Application #
7935796
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1976-07-01
Project End
2013-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
33
Fiscal Year
2009
Total Cost
$6,158
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Santhekadur, Prasanna K; Kumar, Divya P; Sanyal, Arun J (2018) Preclinical models of non-alcoholic fatty liver disease. J Hepatol 68:230-237
Patidar, Kavish R; Kang, Le; Bajaj, Jasmohan S et al. (2018) Fractional excretion of urea: A simple tool for the differential diagnosis of acute kidney injury in cirrhosis. Hepatology 68:224-233
Luo, Yi; Oseini, Abdul; Gagnon, Robert et al. (2018) An Evaluation of the Collagen Fragments Related to Fibrogenesis and Fibrolysis in Nonalcoholic Steatohepatitis. Sci Rep 8:12414
Oseini, Abdul M; Cole, Banumathi K; Issa, Danny et al. (2018) Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis. Hepatol Int 12:6-16
Kumar, Divya P; Santhekadur, Prasanna K; Seneshaw, Mulugeta et al. (2018) A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC. Hepatology :
Srivastava, Jyoti; Robertson, Chadia L; Ebeid, Kareem et al. (2017) A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH). Hepatology 66:466-480
Cazanave, Sophie; Podtelezhnikov, Alexei; Jensen, Kristian et al. (2017) The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease. Sci Rep 7:17193
Jariwala, Nidhi; Rajasekaran, Devaraja; Mendoza, Rachel G et al. (2017) Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res 77:3306-3316
Puri, Puneet; Daita, Kalyani; Joyce, Andrew et al. (2017) The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids. Hepatology :
Oseini, Abdul M; Sanyal, Arun J (2017) Therapies in non-alcoholic steatohepatitis (NASH). Liver Int 37 Suppl 1:97-103

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