This proposal requests support for the continuation of a research training program in academic nephrology, now under the directorship of Dr. Martin Pollak, Chief, Nephrology Division, Beth Israel Deaconess Medical Center (BIDMC) and Professor of Medicine, Harvard Medical School (HMS). Continued support is requested for six trainees who will spend at least two years in the training program. Most candidates will have received the MD degree or the MD-PhD degree prior to entry but prospective trainees with a PhD and a background in a relevant scientific discipline are also considered. The major criterion for selection is evidence of an interest, ability and commitment for a career in investigative nephrology. Research activities span basic and translational investigations. Current research areas include acute renal failure, mechanisms of cell injury and cell metabolism, ion transport and water excretion, cellular transduction mechanisms, mechanisms of muscle wasting and intracellular protein breakdown, preeclampsia, glomerular pathology, genetics of kidney disease, cellular and transplant immunology, gene regulation, genomics and proteomics of the kidney, angiogenesis, vascular leak, diabetic nephropathy, metabolism, and renal bone disease. The chief method of instruction is intensive personal involvement in a research program under the close supervision of an experienced mentor. Participation in a structured program of career mentoring, research seminars, journal clubs, and laboratory presentations is mandatory for all trainees. The primary facility for training is the Nephrology Division at BIDMC, with additional training sites in the Transplant, Rheumatology, and Interdisciplinary Medicine and Biotechnology Divisions at BIDMC, at Children's Hospital Boston, the Dept. of Medicine (Renal Division) at Brigham and Women's Hospital, and the adult and pediatric Renal Units at Massachusetts General Hospital. A variety of core facilities (animal, genetics, imaging, biochemical, etc.) are available at BIDMC and/or Harvard Medical School, the Harvard CTSA, and at the other training sites. These sites are close to each other, facilitating interactions.
There is a well-recognized growing need to educate physician and PhD scientists for research careers in nephrology. Public health will benefit from the significant advances in medicine that can be made by those who have spent several years in a mentored laboratory environment and have learned to apply a range of approaches used in modern biomedical science. This program offers a rigorous training experience to physicians not previously trained in research and to those with PhD degrees who wish to obtain postdoctoral training in kidney-related science. The increasing societal burden of kidney diseases, coupled with a continued nationwide difficulty in attracting physician- scientists to internal medicine in general, and to nephrology in particular, reinforces the public health importance of this program. !
|Lynch, Katherine E; Ghassemi, Fatimah; Flythe, Jennifer E et al. (2016) Sodium modelling to reduce intradialytic hypotension during haemodialysis for acute kidney injury in the intensive care unit. Nephrology (Carlton) 21:870-7|
|Thornley, Thomas B; Agarwal, Krishna A; Kyriazis, Periklis et al. (2016) Contrasting Roles of Islet Resident Immunoregulatory Macrophages and Dendritic Cells in Experimental Autoimmune Type 1 Diabetes. PLoS One 11:e0150792|
|Olabisi, Opeyemi A; Zhang, Jia-Yue; VerPlank, Lynn et al. (2016) APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. Proc Natl Acad Sci U S A 113:830-7|
|Chen, Christina W; Karumanchi, S Ananth (2015) Placental Growth Factor as a Novel Marker in Uremia-Related Cardiovascular Disease. Am J Nephrol 42:115-6|
|Goel, Arvind; Maski, Manish R; Bajracharya, Surichhya et al. (2015) Epidemiology and Mechanisms of De Novo and Persistent Hypertension in the Postpartum Period. Circulation 132:1726-33|
|Feng, Di; DuMontier, Clark; Pollak, Martin R (2015) The role of alpha-actinin-4 in human kidney disease. Cell Biosci 5:44|
|Lee, J; de Louw, E; Niemi, M et al. (2015) Association between fluid balance and survival in critically ill patients. J Intern Med 277:468-77|
|Lynch, Katherine E; Rhee, Connie M; Brunelli, Steven M (2014) Thiazolidinedione use is associated with improved all-cause mortality compared with sulfonylureas among diabetic hemodialysis patients. J Diabetes 6:381-3|
|Ren, Jian-Guo; Seth, Pankaj; Clish, Clary B et al. (2014) Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling. Sci Rep 4:5414|
|Niemi, Matthew; Mandelbrot, Didier A (2014) The Outcomes of Living Kidney Donation from Medically Complex Donors: Implications for the Donor and the Recipient. Curr Transplant Rep 1:1-9|
Showing the most recent 10 out of 39 publications