This is an application for renewal of a longstanding program to provide intensive training in modern methods of nephrologic research to clinically trained individuals with the M.D. or M.D./Ph.D. degree. Continued funding of seven stipends per year is requested for this joint training program that provides support for both """"""""adult"""""""" and pediatric nephrology fellows. Although the highest priority of this program is to train physician-scientists, basic scientist trainees with the Ph.D. degree who are strongly committed to careers in kidney research are also supported whenever possible. Each year 3-4 new trainees are recruited into the program after completing residency training in internal medicine or pediatrics. Only fellows with a strong commitment to multi-year research training are recruited into the program. Training is provided in both laboratory-based and patient-oriented research. The training faculty is drawn from multiple clinical and basic science departments (Internal Medicine, Pediatrics, Biomedical Engineering, Cellular and Molecular Physiology, Cell Biology, Epidemiology and Public Health, Genetics, Immunobiology, Pathology, Pharmacology) and spans diverse biomedical disciplines relevant to kidney disease research (electrolyte physiology and pathophysiology, cell biology and experimental pathology, genetics and developmental biology, immunology and transplantation, vascular biology, tissue engineering, and clinical epidemiology and biostatistics). Although the core of research training is provided through work on a selected research topic under the supervision of an individual preceptor, training is enhanced by a broad array of teaching conferences, seminars and courses. Indeed, many recent fellows have enrolled in graduate degree programs specifically designed for training clinician investigators including the Investigative Medicine Ph.D. program, and the Program in Chronic Disease Epidemiology that leads to a Master of Science in Epidemiology and Public Health. Over the past 35 years this program has trained many leaders in academic nephrology, and the recent track record continues to be outstanding. The overwhelming majority of trainees who completed training during the past 10 years currently hold either full-time academic positions or research-related positions in industry, and many have successfully competed for career development faculty grants from the NIH or American Heart Association (e.g. K08, K23, Fellow-to-Faculty Transition Award) or have already obtained NIH R01 grants. The program also has made progress in achieving ethnic diversity, as four current fellows are underrepresented minority trainees.

Public Health Relevance

Kidney diseases have an enormous impact on the health of Americans and on our nation's health care costs. The goal of the proposed program is to train physician-scientists and basic scientists for academic and research careers dedicated to understanding the mechanisms that cause kidney diseases and to developing new strategies for the prevention and treatment of kidney diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Internal Medicine/Medicine
Schools of Medicine
New Haven
United States
Zip Code
Besse, Whitney; Choi, Jungmin; Ahram, Dina et al. (2018) A noncoding variant in GANAB explains isolated polycystic liver disease (PCLD) in a large family. Hum Mutat 39:378-382
Mansour, Sherry G; Hall, Isaac E; Reese, Peter P et al. (2018) Reliability of deceased-donor procurement kidney biopsy images uploaded in United Network for Organ Sharing. Clin Transplant 32:e13441
Moledina, Dennis G; Luciano, Randy L; Kukova, Lidiya et al. (2018) Kidney Biopsy-Related Complications in Hospitalized Patients with Acute Kidney Disease. Clin J Am Soc Nephrol 13:1633-1640
Moledina, Dennis G; Hall, Isaac E; Thiessen-Philbrook, Heather et al. (2017) Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury. Am J Kidney Dis 70:807-816
Williams, Kenneth R; Colangelo, Christopher M; Hou, Lin et al. (2017) Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant. Proteomics Clin Appl 11:
Besse, Whitney; Dong, Ke; Choi, Jungmin et al. (2017) Isolated polycystic liver disease genes define effectors of polycystin-1 function. J Clin Invest 127:1772-1785
Mansour, Sherry G; Puthumana, Jeremy; Coca, Steven G et al. (2017) Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review. BMC Nephrol 18:72
Pober, Jordan S; Merola, Jonathan; Liu, Rebecca et al. (2017) Antigen Presentation by Vascular Cells. Front Immunol 8:1907
Merola, Jonathan; Jane-Wit, Daniel D; Pober, Jordan S (2017) Recent advances in allograft vasculopathy. Curr Opin Organ Transplant 22:1-7
Montgomery, Tinika A; Xu, Leyuan; Mason, Sherene et al. (2017) Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts. J Am Soc Nephrol 28:3218-3226

Showing the most recent 10 out of 97 publications