The goal of the Metabolism Training Program is to provide our graduate students and postdoctoral scholars with in-depth training in modern metabolic research. Our training environment integrates traditional areas of metabolism with the latest advances in molecular biology, cellular biology, genetics, proteomics, mass spectrometry, and nuclear magnetic resonance. Our training faculty, drawn from basic and clinical science departments of the School of Medicine, have active, grant-supported research programs and an outstanding record of training. Each trainee is admitted to the program uncommitted to an individual scientist, and selects an advisor from the training faculty after extensive interviews. The Steering Committee, chaired by the PI, manages all academic and research aspects of the Program. In particular, the Steering Committee closely monitors the matching of trainees with advisors, as well as the research and academic progress of the trainees. An extensive set of courses in metabolism has been established between the Departments of Nutrition, Biochemistry, Genetics, Molecular Biology, Pharmacology, Physiology and Biomedical Engineering. Trainees participate in a Journal Club and in monthly seminars and discussion groups in metabolic regulation. Research training ranges from the use of isotopic tracers to study whole body metabolism in humans to the construction of gene """"""""knock-outs"""""""" to test the function of regulatory proteins on metabolic processes. Postdoctoral trainees include PhD and MD scholars with backgrounds in clinical medicine. Graduate students, drawn from a number of departments of the School of Medicine, are enrolled in the PhD or MD/PhD programs of CWRU. A high percentage of our trainees hold academic positions at US universities and medical schools. The Program is dedicated to increase the number of minority scientists. It has helped establish a Minority Scholars Program for college graduates interested in a career in the biomedical sciences.
(Seeinstructions): About one-half of the US population dies of metabolic and nutritional diseases. At present, few basic science and clinical investigators have expertise in modern techniques for investigating metabolism in health and disease. The goal of our Metabolism Training Program is to train young investigators to conduct research on metabolic diseases.
|Roychowdhury, Sanjoy; McCullough, Rebecca L; Sanz-Garcia, Carlos et al. (2016) Receptor interacting protein 3 protects mice from high-fat diet-induced liverÂ injury. Hepatology 64:1518-1533|
|Babcook, Melissa A; Joshi, Aditya; Montellano, Jeniece A et al. (2016) Statin Use in Prostate Cancer: An Update. Nutr Metab Insights 9:43-50|
|Smathers, Rebecca L; Chiang, Dian J; McMullen, Megan R et al. (2016) Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice. Mol Immunol 72:9-18|
|McCullough, Rebecca L; McMullen, Megan R; Das, Dola et al. (2016) Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice. Mol Immunol 75:122-32|
|Majumder, Mithu; Mitchell, Daniel; Merkulov, Sergei et al. (2015) Residues required for phosphorylation of translation initiation factor eIF2Î± under diverse stress conditions are divergent between yeast and human. Int J Biochem Cell Biol 59:135-41|
|Solomon, Thomas P J; Malin, Steven K; Karstoft, Kristian et al. (2015) Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum. Diabetes Care 38:921-9|
|Malin, Steven K; Kirwan, John P; Sia, Chang Ling et al. (2015) Pancreatic Î²-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-ÎºB activation and systemic inflammation. Am J Physiol Endocrinol Metab 308:E770-7|
|Navaneethan, Sankar D; Malin, Steven K; Arrigain, Susana et al. (2015) Bariatric surgery, kidney function, insulin resistance, and adipokines in patients with decreased GFR: a cohort study. Am J Kidney Dis 65:345-7|
|DeSantis, David A; Ko, Chih-Wei; Wang, Lan et al. (2015) Constitutive Activation of the Nlrc4 Inflammasome Prevents Hepatic Fibrosis and Promotes Hepatic Regeneration after Partial Hepatectomy. Mediators Inflamm 2015:909827|
|Navaneethan, Sankar D; Fealy, Ciaran E; Scelsi, Amanda C et al. (2015) A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease. Am J Nephrol 42:274-81|
Showing the most recent 10 out of 82 publications