This competitive renewal of a Training Program in Endocrinology, Diabetes and Metabolism (DK07352) was combined in 1988 from programs in Endocrinology funded in 1968 (DK07147) and Diabetes and Metabolism funded in 1979 (DK07352). The Program provides postdoctoral research training in Diabetes, Endocrinology and Metabolism for individuals with MD or PhD degrees, preparing trainees for academic careers as independent investigators and provides up to three years of laboratory research training. The faculty consist of 17 investigators funded with NIH R01 grants and/or other funds, 2 junior faculty members, who are developing independent programs and have some form of support, and 67 adjunct faculty in both basic science and clinical departments. The Program is designed to provide trainees with: (i) all components of the scientific method, (ii) a focused approach to scientific investigation, (iii) experience with the most modern analytical tools and methodologies, (iv) grant writing skills, and (v) capability to develop as independent biomedical research scientists. The components of the Program include formal didactic course work, seminars and conferences, intra- and extra-mural scientific presentations, a focused research experience in the laboratories of established investigators, and grant writing. The Program is administered by the Steering Committee, chaired by the Program Director, which is responsible for the trainees'appointment and laboratory assignment, development of didactic curricula, review of trainees'initial project, and annual review of trainees'progress. Of particular note in the Program are the focused approach to training goals for each laboratory-based trainee, a strong commitment to provide maximal training duration, the uniform extramural funding of the independent investigators that serve as primary faculty, the productive training record of the training program, the presence of an enthusiastic and knowledgeable junior training faculty, the availability of adjunct faculty whose primary areas of basic science and/or clinical investigation are intimately tied to those of metabolism, diabetes and endocrinology, and the diversity of the faculty research programs which range from molecular endocrinology to clinical research. Due to the program's popularity and success and the large increase in research funds awarded to our highly qualified faculty, we request to continue our program at the current level of 6 fellowship slots.

Public Health Relevance

The relevance of this application is to provide training in basic and clinical science to enable the next generation of investigators to conduct research with the goal of improving health care and delivery.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
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Mayo Clinic, Rochester
United States
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Farr, Joshua N; Laddu, Deepika R; Going, Scott B (2014) Exercise, hormones and skeletal adaptations during childhood and adolescence. Pediatr Exerc Sci 26:384-91
Drake, Matthew T; Farr, Joshua N (2014) Inhibitors of sclerostin: emerging concepts. Curr Opin Rheumatol 26:447-52
Limberg, Jacqueline K; Curry, Timothy B; Prabhakar, Nanduri R et al. (2014) Is insulin the new intermittent hypoxia? Med Hypotheses 82:730-5
Bush, Nikki C; Triay, Jessica M; Gathaiya, Nicola W et al. (2014) Contribution of very low-density lipoprotein triglyceride fatty acids to postabsorptive free fatty acid flux in obese humans. Metabolism 63:137-40
Farr, Joshua N; Khosla, Sundeep; Achenbach, Sara J et al. (2014) Diminished bone strength is observed in adult women and men who sustained a mild trauma distal forearm fracture during childhood. J Bone Miner Res 29:2193-202
Weroha, S John; Becker, Marc A; Enderica-Gonzalez, Sergio et al. (2014) Tumorgrafts as in vivo surrogates for women with ovarian cancer. Clin Cancer Res 20:1288-97
Farr, Joshua N; Amin, Shreyasee; Melton 3rd, L Joseph et al. (2014) Bone strength and structural deficits in children and adolescents with a distal forearm fracture resulting from mild trauma. J Bone Miner Res 29:590-9
Farr, Joshua N; Zhang, Wei; Kumar, Shaji K et al. (2014) Altered cortical microarchitecture in patients with monoclonal gammopathy of undetermined significance. Blood 123:647-9
Limberg, Jacqueline K; Taylor, Jennifer L; Dube, Simmi et al. (2014) Role of the carotid body chemoreceptors in baroreflex control of blood pressure during hypoglycaemia in humans. Exp Physiol 99:640-50
Ota, Kuniaki; Quint, Patrick; Ruan, Ming et al. (2013) TGF-* induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. Endocrinology 154:3745-52

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