This competitive renewal of a Training Program in Diabetes and Metabolism (DK07352) was combined in 1988 from programs in Endocrinology funded in 1968 (DK07147) and Diabetes and Metabolism funded in 1979 (DK07352). The Program provides postdoctoral research training in Diabetes and Metabolism for individuals with MD or PhD degrees, preparing trainees for academic careers as independent investigators and provides up to three years of laboratory research training. The faculty consist of 18 investigators funded with NIH R01 grants and/or other funds, 3 junior faculty members, who are developing independent programs and have some form of support, and 58 adjunct faculty in both basic science and clinical departments. The Program is designed to provide trainees with: (i) all components of the scientific method, (ii) a focused approach to scientific investigation, (iii) experience with the most modern analytical tools and methodologies, (iv) grant writing skills, and (v) capability to develop as independent biomedical research scientists. The components of the Program include formal didactic course work, seminars and conferences, intra- and extra-mural scientific presentations, a focused research experience in the laboratories of established investigators, and grant writing. The Program is administered by the Steering Committee, chaired by the Program Director, which is responsible for the trainees'appointment and laboratory assignment, development of didactic curricula, review of trainees'initial project, and annual review of trainees'progress. Of particular note in the Program are the focused approach to training goals for each laboratory-based trainee, a strong commitment to provide maximal training duration, the uniform extramural funding of the independent investigators that serve as primary faculty, the productive training record of the training program, the presence of an enthusiastic and knowledgeable junior training faculty, the availability of adjunct faculty whose primary areas of basic science and/or clinical investigation are intimately tied to those of metabolism, diabetes and endocrinology, and the diversity of the faculty research programs which range from molecular endocrinology to clinical research. Due to the program's popularity and success and the large amount of research funds awarded to our highly qualified faculty, we request to continue our program at the current level of 6 fellowship slots.

Public Health Relevance

This application is for renewal of a Training Program in Diabetes and Metabolism that has been funded for the last 35 years. The Program provides postdoctoral research training in Diabetes and Metabolism for 6 individuals for a maximum of three years. Trainees must have MD, PhD, or MD/PhD degrees. The program prepares trainees for academic careers as independent investigators. Trainees work in the laboratories of 18 investigators, who have extramural funds to support their research programs and who use the latest technologies. The Program is designed to provide trainees with a thorough understanding of the scientific method, a focused approach to scientific investigation, experience with the lates analytical tools and methodologies, grant writing skills, and capability to develop as independent biomedical research scientists. The program's goal is to provide the next generation of highly qualified researchers, who will continue to improve our ability to provide state-of-the-art diagnosis and treatment of patients with endocrine disorders.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007352-36
Application #
8663064
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Becker, Marc A; Hou, Xiaonan; Tienchaianada, Piyawan et al. (2016) Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer. BMC Cancer 16:814
Espinosa De Ycaza, Ana E; Rizza, Robert A; Nair, K Sreekumaran et al. (2016) Effect of Dehydroepiandrosterone and Testosterone Supplementation on Systemic Lipolysis. J Clin Endocrinol Metab 101:1719-28
Johnson, Matthew L; Distelmaier, Klaus; Lanza, Ian R et al. (2016) Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults. Diabetes 65:74-84
Varghese, Ron T; Viegas, Ivan; Barosa, Cristina et al. (2016) Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance. Diabetes 65:887-92
Shah, Meera; Varghese, Ron T; Miles, John M et al. (2016) TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes. Diabetes 65:371-80
Konopka, Adam R; Esponda, Raul Ruiz; Robinson, Matthew M et al. (2016) Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes. Cell Rep 15:1394-400
Cao, Hong; Schroeder, Barbara; Chen, Jing et al. (2016) The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase. J Biol Chem 291:16424-37
Lalia, Antigoni Z; Dasari, Surendra; Johnson, Matthew L et al. (2016) Predictors of Whole-Body Insulin Sensitivity Across Ages and Adiposity in Adult Humans. J Clin Endocrinol Metab 101:626-34
Limberg, Jacqueline K; Taylor, Jennifer L; Mozer, Michael T et al. (2015) Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during hypoglycemia. Hypertension 65:1365-71
Morgan-Bathke, Maria; Chen, Liang; Oberschneider, Elisabeth et al. (2015) Sex and depot differences in ex vivo adipose tissue fatty acid storage and glycerol-3-phosphate acyltransferase activity. Am J Physiol Endocrinol Metab 308:E830-46

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