For more than 30 years, the Integrated Training Program in Diabetes, Endocrinology and Metabolism (DEM) has supported and enhanced research training in DEM for predoctoral and postdoctoral trainees at University of California San Francisco. Track 1, the predoctoral training path, operates with the UCSF Biomedical Sciences Graduate Program, which trains students for research careers investigating basic mechanisms of human physiology and disease, to integrate training and strengthen opportunities for graduate students interested in research careers in DEM. Postoctoral training includes two tracks. Track 2 supports mentored postdoctoral research training in DEM. Track 3 combines clinical and research training for physician-scientists. Postdoctoral trainees in Track 2 or 3 may train in the Basic Investigator or Clinical Investigator Pathways. Both pathways provide a combination of didactic (seminars, lectures, journal clubs) and individually-mentored research training. Training for Clinical Investigators includes courses in Epidemiology, Biostatistics, and Clinical Study Design. All predoctoral and postdoctoral DEM trainees participate in seminars on the Ethics and Responsible Conduct of Science. Trainees work with a large, accomplished, and interactive DEM faculty drawn from 13 academic departments and 7 Organized Research Units/Institutes across UCSF. The majority (91%) of the predoctoral trainees who have earned their PhDs are now in postdoctoral research fellowships or academic research faculty positions. Of the postdoctoral trainees who completed their fellowships during this funding period, 69% hold academic faculty positions, and 59% remain in research. New improvements to the DEM Program include a formal Career Mentoring Program, a new summer research program for medical students, an annual retreat, increased integration with the NIH/NIDDK-supported UCSF Diabetes and Endocrinology Center (DERC) and expansion to the new basic science campus at UCSF Mission Bay. Together these changes enhance the already strong DEM Training Program and will expand future opportunities in DEM for both predoctoral and postdoctoral trainees at UCSF.

Public Health Relevance

The Integrated Training Program in Diabetes, Endocrinology and Metabolism (DEM) enhances research training in Endocrinology and Metabolism at University of California San Francisco (UCSF) by supporting didactic education, mentored research experience and career mentoring for scientists in training. Research performed by scientists trained through the UCSF DEM Program contributes to our understanding of endocrine and metabolic diseases and to improvements in the lives of people suffering from these disorders.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZDK1-GRB-J (J1))
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Castle, Arthur
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Folias, Alexandra E; Penaranda, Cristina; Su, Anthony L et al. (2014) Aberrant innate immune activation following tissue injury impairs pancreatic regeneration. PLoS One 9:e102125
Feuer, Sky K; Donjacour, Annemarie; Simbulan, Rhodel K et al. (2014) Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes. Endocrinology 155:4554-67
Evans, Daniel S; Calton, Melissa A; Kim, Mee J et al. (2014) Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One 9:e96805
Bloise, Enrrico; Feuer, Sky K; Rinaudo, Paolo F (2014) Comparative intrauterine development and placental function of ART concepti: implications for human reproductive medicine and animal breeding. Hum Reprod Update 20:822-39
Thomas, Hilary R; Gitelman, Stephen E (2013) Altering the course of type 1 diabetes: an update on prevention and new-onset clinical trials. Pediatr Diabetes 14:311-21
Harris, Charles; Roohk, Donald J; Fitch, Mark et al. (2013) Large increases in adipose triacylglycerol flux in Cushingoid CRH-Tg mice are explained by futile cycling. Am J Physiol Endocrinol Metab 304:E282-93
Roohk, Donald J; Mascharak, Smita; Khambatta, Cyrus et al. (2013) Dexamethasone-mediated changes in adipose triacylglycerol metabolism are exaggerated, not diminished, in the absence of a functional GR dimerization domain. Endocrinology 154:1528-39
Feuer, S K; Camarano, L; Rinaudo, P F (2013) ART and health: clinical outcomes and insights on molecular mechanisms from rodent studies. Mol Hum Reprod 19:189-204
Ku, Gregory M; Pappalardo, Zachary; Luo, Chun Chieh et al. (2012) An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet 8:e1002449
Swarbrick, Michael M; Evans, Daniel S; Valle, Maria I et al. (2011) Replication and extension of association between common genetic variants in SIM1 and human adiposity. Obesity (Silver Spring) 19:2394-403

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