This is a 5-year renewal application to support 5 postdoctoral trainees for a broad program in Academic Endocrinology. This program has been in place at the Brigham and Women's Hospital/Harvard Medical School since 1985 and has been highly successful in training physicians and basic scientists, many of whom remain in academic endocrinology. In the last 10 year period, 67% of the 18 trainees completing their training remain in a research career. The faculty combines both the physician-scientists of the Endocrinology Division with those basic scientists on the Harvard Medical School faculty whose research is significantly related to endocrinology. Over the last ten years, these 16 faculty individuals have trained over 300 postdoctoral fellows, over 95% of whom remain in research-related careers, either in academic positions or in industry. The faculty are well-funded, with estimated modified direct costs per annum of over $50 million. The 5 trainees appointed each year will be individuals with MD, PhD, or MD/PhD degrees and they will undertake 3-4 years of an intensive research experience in either basic or clinical investigation. The goal of the program is to provide the trainees with sufficient expertise to apply successfully for mentored research awards, such as K23, K08, or K01 awards, or R01 grants, when indicated. The areas of research interest of the faculty include regulation of energy expenditure, insulin sensitivity, mechanisms of calcium signaling, the role of the iodothyronine deiodinases in controlling differentiation and cell division via local activation and inactivation of thyroid hormone, the process of bone development and its clinical implications, the study of G-protein-coupled receptors, particularly in the hypothalamus, the control of skeletal muscle repair and mechanisms of muscle proteolysis in cachexia and muscle atrophy, the mechanisms of steroid hormone action and the epidemiology of diabetes, obesity, and vitamin D-deficiency disorders. Individuals in this program will also be trained to translate the insights they gain to develop strategies for the treatment and prevention of common endocrinology-based public health problems, including diabetes, obesity and osteoporosis.

Public Health Relevance

This Endocrinology Training Program assembles a group of outstanding clinical and basic scientists to oversee the training of fellows with an interest in understanding the regulation and mechanism of hormone effects and how they are disrupted to produce clinical disorders. Fellows will be trained in either basic or clinical research techniques in order to contribute to the understanding and treatment of major endocrine-related disorders, such as obesity, diabetes, and osteoporosis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007529-26
Application #
8281713
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Castle, Arthur
Project Start
1985-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
26
Fiscal Year
2012
Total Cost
$201,657
Indirect Cost
$14,411
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Liu, Eva S; Martins, Janaina S; Raimann, Adalbert et al. (2016) 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. J Bone Miner Res 31:929-39
Liu, Xiaoyun; Medici, Marco; Kwong, Norra et al. (2016) Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis. Thyroid 26:256-61
Liu, Eva S; Raimann, Adalbert; Chae, Byongsoo Timothy et al. (2016) c-Raf promotes angiogenesis during normal growth plate maturation. Development 143:348-55
Medici, Marco; Kwong, Norra; Angell, Trevor E et al. (2015) The variable phenotype and low-risk nature of RAS-positive thyroid nodules. BMC Med 13:184
Angell, Trevor E; Frates, Mary C; Medici, Marco et al. (2015) Afirma Benign Thyroid Nodules Show Similar Growth to Cytologically Benign Nodules During Follow-Up. J Clin Endocrinol Metab 100:E1477-83
Kwong, Norra; Medici, Marco; Angell, Trevor E et al. (2015) The Influence of Patient Age on Thyroid Nodule Formation, Multinodularity, and Thyroid Cancer Risk. J Clin Endocrinol Metab 100:4434-40
Luongo, Cristina; Martin, Cecilia; Vella, Kristen et al. (2015) The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism. Endocrinology 156:745-54
Simavli, Serap; Thompson, Iain R; Maguire, Caroline A et al. (2015) Substance p regulates puberty onset and fertility in the female mouse. Endocrinology 156:2313-22
Nou, Eric; Kwong, Norra; Alexander, Lukas K et al. (2014) Determination of the optimal time interval for repeat evaluation after a benign thyroid nodule aspiration. J Clin Endocrinol Metab 99:510-6

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