The major components of the Nephrology T32 program at the Massachusetts General Hospital (MGH) are integrated to offer comprehensive multidisciplinary research training to 4 highly selected postdoctoral trainees per year (each receiving a minimum of 2 years of support) under the supervision of 19 senior mentors with diverse and complementary research expertise. Our goal is to train the future leaders of Academic Nephrology. The program includes an exceptionally well-equipped research environment with state-of-the-art technologies. Our collaborative training program provides formal didactic instruction and enrichment activities critically important during the formative training years, and all research trainees complete a program in the Responsible Conduct of Research. Our program has a strong foundation in the Basic Sciences, and an emerging expertise in Clinical and Translational (C/T) Science. The 3 major components of our T32 Program are as follows: A. Training Organized by Established and Emerging Disciplines. The program has a continued focus in Basic (or Fundamental) Research and a growing expertise in C/T Research. Our highly selected and well- funded senior mentoring pool is strongly aligned in these two areas. We have also specifically added a concentration in the area of genetics and genomics of kidney disease, built around the new Associate Director, Iain Drummond PhD, with a total of 4 senior mentors in this area. B. Training Tailored to the Background of Trainees with the Number of Trainees Optimized. In this renewal, we request 4 postdoctoral positions (from our original 7) that will be offered on an annual basis to selected candidates with PhD, MD-PhD or MD degrees. In general, two will be allocated to trainees with a focus in basic research and two to trainees with a focus in C/T research. The profile of our diverse applicants over the past 5 years suggests we will have an excellent applicant pool to meet this balance. The duration of support will be individualized. We provide tuition support for formal instructional courses to trainees in a variety of areas including C/T Science, and in areas of Basic Science for MDs who are committed to a fundamental research track but have minimal wet bench experience. C. Training Facilities and Resources. Training is conducted in the laboratories of our Mentors, a collaborative group of established investigators with strong training records and achievements in kidney research. The MGH Division of Nephrology laboratories collectively occupy >20,000 sq ft of dedicated research space, with over 80% allocated to wet-bench space. Training in C/T Research includes access to the full range of acute and chronic care settings at MGH, including intensive care units, hemodialysis and transplant units and numerous outpatient clinics, and an infrastructure involving statisticians, research coordinators, technicians, and dedicated space to perform human studies.

Public Health Relevance

This application requests funding to enhance MGH's rigorous and selective T32 Nephrology Training Program whose aim is to prepare new scientists for independent research careers in Academic Nephrology. A select group of highly motivated investigators (PhD, MD-PhD, or MD) at the postdoctoral level will be trained by MGH's versatile faculty to conduct basic and clinical/translational research using interdisciplinary state-of-the- art technologies to address complex biomedical problems related to the causes of and cures for kidney and related diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007540-31A1
Application #
9276940
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1986-07-01
Project End
2022-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
31
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02114
Poyan Mehr, Ali; Tran, Mei T; Ralto, Kenneth M et al. (2018) De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med 24:1351-1359
Lim, Kenneth; Hamano, Takayuki; Thadhani, Ravi (2018) Vitamin D and Calcimimetics in Cardiovascular Disease. Semin Nephrol 38:251-266
Nguyen, Hai Dang; Leong, Wan Yee; Li, Weiling et al. (2018) Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes. Cancer Res 78:5363-5374
Pang, Paul; Abbott, Molly; Abdi, Malyun et al. (2018) Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant 33:923-934
Kabeche, Lilian; Nguyen, Hai Dang; Buisson, RĂ©mi et al. (2018) A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation. Science 359:108-114
Cortazar, Frank B; Leaf, David E; Owens, Charles T et al. (2017) Combination therapy with rituximab, low-dose cyclophosphamide, and prednisone for idiopathic membranous nephropathy: a case series. BMC Nephrol 18:44
Cortazar, Frank B; Pendergraft 3rd, William F; Wenger, Julia et al. (2017) Effect of Continuous B Cell Depletion With Rituximab on Pathogenic Autoantibodies and Total IgG Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Rheumatol 69:1045-1053
Olabisi, Opeyemi A; Heneghan, John F (2017) APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It? Semin Nephrol 37:546-551
Tangren, Jessica Sheehan; Powe, Camille E; Ankers, Elizabeth et al. (2017) Pregnancy Outcomes after Clinical Recovery from AKI. J Am Soc Nephrol 28:1566-1574
Dehnadi, Abbas; Benedict Cosimi, A; Neal Smith, Rex et al. (2017) Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys. Nat Commun 8:13899

Showing the most recent 10 out of 78 publications