The T32 training program submitted offers 2-3 years of fellowship designed to prepare physicians and post-doctoral candidates for investigative careers in the area of obesity. The program provides a structured curriculum in the first 2 years, in combination with a research experience emphasizing either basic laboratory or translational research. Trainees are appointed as post-doctoral fellows at Columbia University, allowing for part-time course work, and a number of course requirements are required, different for basic scientists and translational scientists, and also depending on previous training. Trainees are incorporated into the investigative programs of faculty members at the New York Obesity Nutrition Research Center, which is a consortium including St. Luke's Roosevelt Hospital Center, Columbia University Medical Center, and Albert Einstein College of Medicine which has strong administrative support from the 3 institutions. Trainees elect to work with a faculty member at one of the 3 sites. The faculty's multidisciplinary nature (physicians, biochemists, cell biologists, psychologists, nutritionists, geneticists and statisticians) allows a multidisciplinary approach on the part of the trainees. Strong collaborative ties among the training faculty make this possible. Trainees have available multiple techniques in enzymology, cell culture, molecular genetics and gene cloning, body composition, calorimetry, metabolic balance, nutritional assessment, stable isotope methodology, hormone and metabolite assays, hormone receptor biochemistry, ingestive behavior, animals models of obesity, and many more. Trainees are (1) physicians who have completed 3 to 5 years of post-graduate clinical training, (2) recent Ph.D (or equivalent) recipients in disciplines including (but not limited) to genetics, biochemistry, nutrition, psychology, physiology, neuroendocrinology, neuroscience, or pharmacology. Individuals are selected on the basis of their demonstrated competence in graduate school, recommendations of previous faculty and consideration of the degree to which their research interests fit in with those of the faculty. All trainees must have a future plan for an investigative career in the area of obesity, eating disorders, or appetitive behavior. Each of the cooperating faculty laboratories is well equipped and funded to support the trainee's research in an optimal manner. The program aims to develop independent investigative skills and a rigorous approach to investigation through courses, seminars and individual mentoring. Funding for 6 trainees is requested.

Public Health Relevance

There is a dearth of scientists adequately prepared for investigation in the area of obesity, yet there is a great need because obesity has become a major public health problem in our nation. The objective of this training program is to educate young scientists through academic course work and research experience so that they will become independent investigators and assume leadership positions in the effort to understand, prevent, and treat obesity.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
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St. Luke's-Roosevelt Institute for Health Sciences
New York
United States
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Hull, H R; Thornton, J; Paley, C et al. (2015) Maternal obesity influences the relationship between location of neonate fat mass and total fat mass. Pediatr Obes 10:245-51
Dutia, Roxanne; Brakoniecki, Katrina; Bunker, Phoebe et al. (2014) Limited recovery of *-cell function after gastric bypass despite clinical diabetes remission. Diabetes 63:1214-23
Dutia, Roxanne; Brakoniecki, Katrina; Bunker, Phoebe et al. (2014) Response to comment on Dutia et al. Limited recovery of ?-cell function after gastric bypass despite clinical diabetes remission. Diabetes 2014;63:1214-1223. Diabetes 63:e4
Hull, Holly R; Thornton, John C; Ji, Ying et al. (2011) Higher infant body fat with excessive gestational weight gain in overweight women. Am J Obstet Gynecol 205:211.e1-7
Davidson, Lance E; Wang, Jack; Thornton, John C et al. (2011) Predicting fat percent by skinfolds in racial groups: Durnin and Womersley revisited. Med Sci Sports Exerc 43:542-9
Bose, Mousumi; Machineni, Sriram; Olivan, Blanca et al. (2010) Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding. Obesity (Silver Spring) 18:1085-91
Bose, Mousumi; Olivan, Blanca; Laferrere, Blandine (2009) Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic disease. Curr Opin Endocrinol Diabetes Obes 16:340-6
Nolan, Laurence J; Guss, Janet L; Liddle, Rodger A et al. (2003) Elevated plasma cholecystokinin and appetitive ratings after consumption of a liquid meal in humans. Nutrition 19:553-7
Ferrante Jr, A W; Thearle, M; Liao, T et al. (2001) Effects of leptin deficiency and short-term repletion on hepatic gene expression in genetically obese mice. Diabetes 50:2268-78
Chung, W K; Luke, A; Cooper, R S et al. (1999) Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis. Diabetes 48:1890-5

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