This is a competing renewal application to continue training postdoctoral fellows in nephrology research. Our goal is to prepare fellows for a career in Academic Nephrology by training them to use modern techniques of cellular and molecular biology or epidemiology and clinical investigation while investigating a specific project. We will continue to rely on an interdisciplinary approach that involves preceptors from the Renal Division and from the Departments of Physiology and Surgery, and from Cardiology and Gastroenterology. Our proposed program is based on ongoing scientific interactions between faculty of the Renal Division and the Basic Sciences. The Director of the Training Grant will be Dr. Jeff M. Sands and the Co-Directors will be Dr. Douglas C. Eaton and Dr. S. Russ Price. Each of the 15 preceptors has an outstanding training record and research funding from the NIH and/or VA. Proposed research projects can be grouped into four major areas based on the questions being addressed: physiology;cellular and molecular biology;transplant immunology;and epidemiology/clinical investigation. We believe involving trainees directly in a specific project plus formal and informal courses in statistics and in cellular and molecular biology, and interaction with clinical investigators will provide them with a first-rate opportunity to develop a career in Academic Medicine. Two categories of trainees will be chosen: 1) M.D.s or M.D./Ph.D.s from the Adult and Pediatric Nephrology Fellowship programs;and 2) Ph.D. candidates. Over the past 10 years, there have been 16 trainees supported by this grant: 8 continue to pursue academic careers in basic or clinical research with full-time medical school faculty positions, 1 is in Internal Medicine residency training, 5 are in nephrology practice, and 2 will be entering their second year of research training during the last year of the current funding period. Thus, 8 of the 13 trainees (62%) who completed all of their training during 2000-2010 entered academic medicine and are currently full-time faculty members at a medical school. The 16 trainees included 7 women and 4 members of an under-represented minority group. Ten of the 14 trainees who have completed training have published peer-reviewed papers;the other 4 trainees have published abstracts and presented their data at National scientific meetings. We have filled every available position every year since the start of this program in 1990. We seek funding to continue this successful training program.

Public Health Relevance

Our goal is to train the next generation of renal investigators in order to improve our understanding of renal disease in patients. Our research program will teach young investigators to apply modern techniques to answer questions related to the consequences of kidney disease. This offers an excellent opportunity to identify and treat these conditions. We have designed a Training Program that emphasizes existing interactions between Renal Division faculty and investigators in other Divisions and Departments at Emory.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007656-24
Application #
8712458
Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Hudson, Matthew B; Rahnert, Jill A; Zheng, Bin et al. (2014) miR-182 attenuates atrophy-related gene expression by targeting FoxO3 in skeletal muscle. Am J Physiol Cell Physiol 307:C314-9
Thai, Tiffany L; Yu, Ling; Eaton, Douglas C et al. (2014) Basolateral P2X?channels stimulate ENaC activity in Xenopus cortical collecting duct A6 cells. Am J Physiol Renal Physiol 307:F806-13
Williams, Clintoria R; Gooch, Jennifer L (2014) Calcineurin A* regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose. J Biol Chem 289:4896-905
Hudson, Matthew B; Woodworth-Hobbs, Myra E; Zheng, Bin et al. (2014) miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export. Am J Physiol Cell Physiol 306:C551-8
Bao, Hui-Fang; Thai, Tiffany L; Yue, Qiang et al. (2014) ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase C* knockout mice. Am J Physiol Renal Physiol 306:F309-20
Thomas, Sandhya S; Mitch, William E (2013) Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin. Clin Exp Nephrol 17:174-82
Pena, Juan A; Titus, Lauren; Jackson, Jennifer et al. (2013) Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem. Transplantation 96:239-44
Ilori, Titilayo O; Blount, Mitsi A; Martin, Christopher F et al. (2013) Urine concentration in the diabetic mouse requires both urea and water transporters. Am J Physiol Renal Physiol 304:F103-11
Hudson, Matthew B; Price, S Russ (2013) Calcineurin: a poorly understood regulator of muscle mass. Int J Biochem Cell Biol 45:2173-8
Ilori, Titilayo O; Wang, Yanhua; Blount, Mitsi A et al. (2012) Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1. Am J Physiol Renal Physiol 302:F998-F1004

Showing the most recent 10 out of 38 publications