? The goal of this training program is to graduate physican-scientists to assume leadership roles in the field of academic Pediatric Nephrology. This is accomplished by an intense year of clinical training in all aspects of Pediatric Nephrology practice, supported by funds that are separate from this grant, followed by two-three years of comprehensive research training, either in basic science or clinical research. Trainees who complete the program are fully sub-board eligible in Pediatric Nephrology and expected to assume faculty positions at academic institutions and to begin the transition to independent investigative careers, usually via one of the mentored scientist programs. This program was developed in direct response to a critical manpower shortage in academic pediatric neprhology, which was/is coupled with the realization that most traditional pediatric nephrology training programs in this country are funded by clinical revenues and, therefore, provide inadequate research training in basic science and clinical investigation. It is estimaged that there is currently one pediatric nephrologist available in the U.S.A. for every 200,000 children. Comparatively, there are an estimated fourteen internist nephrologists per every 60,000 adults. Given recent significant advances in both molecular biology and clinical research, few traditional training programs in pediatric nephrology are presently designed to provide trainees with an opportunity to acquire substantive expertise with the methodologies and concepts of these disciplines. More than 6500 American children suffer from end-stage renal disease (ESRD), and many times that number are affected by chronic kidney disease. Currently, the entire ESRD program costs nearly $25 billion, with the federal government spending more than $17 billion. Despite these efforts, children receiving dialysis and transplantation have unacceptably high mortality rates, 3 times that of adults and more than 15% of the infant population. The reasons for this high mortality remain poorly defined, and, unfortunately, few studies are currently in progress to address this issue. Furthermore, it is now evident that many of the diseases that cause chronic kidney diseasse in adults begin in childhood. There is a pressing need to address these public health issues of kidney disease in children through research, and to train new physician-scientists to perform that critical work. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007662-17
Application #
7276760
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
Project Start
1991-09-30
Project End
2011-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
17
Fiscal Year
2007
Total Cost
$207,981
Indirect Cost
Name
University of Washington
Department
Pediatrics
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Starr, Michelle C; Chang, Irene J; Finn, Laura S et al. (2018) COQ2 nephropathy: a treatable cause of nephrotic syndrome in children. Pediatr Nephrol 33:1257-1261
Engen, Rachel M; Park, Giulia E; Schumacher, Cooper S et al. (2018) Donor-specific Antibody Surveillance and Graft Outcomes in Pediatric Kidney Transplant Recipients. Transplantation 102:2072-2079
Richardson, Kelsey L; Weiss, Noel S; Halbach, Susan (2018) Chronic School Absenteeism of Children with Chronic Kidney Disease. J Pediatr 199:267-271
Starr, Michelle C; Hingorani, Sangeeta R (2018) Prematurity and future kidney health: the growing risk of chronic kidney disease. Curr Opin Pediatr 30:228-235
Starr, Michelle C; Fisher, Kelly; Thompson, Kirsten et al. (2018) A pilot investigation of food insecurity among children seen in an outpatient pediatric nephrology clinic. Prev Med Rep 10:113-116
Engen, Rachel M; Huang, Meei-Li; Park, Giulia E et al. (2018) Prospective Assessment of Adenovirus Infection in Pediatric Kidney Transplant Recipients. Transplantation 102:1165-1171
Starr, Michelle C; Askenazi, David J; Goldstein, Stuart L et al. (2018) Impact of processing methods on urinary biomarkers analysis in neonates. Pediatr Nephrol 33:181-186
Starr, Michelle C; Flynn, Joseph T (2018) Neonatal hypertension: cases, causes, and clinical approach. Pediatr Nephrol :
Engen, Rachel M; Killien, Elizabeth Y; Davis, Jessica L et al. (2017) C septicum Complicating Hemolytic Uremic Syndrome: Survival Without Surgical Intervention. Pediatrics 139:
Paloian, Neil J; Leaf, Elizabeth M; Giachelli, Cecilia M (2016) Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification. Kidney Int 89:1027-1036

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