There is a tremendous need in the United States to increase the number of academic investigators who perform research that will directly impact the care of patients with digestive diseases. For many of these disorders, the fundamental pathobiology is not well understood and effective disease-modifying treatments are not available. This proposal describes the continuation of the combined adult-pediatric Training in Gastroenterology Program that provides multidisciplinary training for postdoctoral scientists in basic research or in clinical/translational research, and which is committed to equipping young investigators with the skill set necessary to overcome obstacles preventing them from developing into successful academic leaders. The Divisions of Adult and Pediatric Gastroenterology, Hepatology and Nutrition and the Vanderbilt Digestive Diseases Research Center (VDDRC) have a long and successful history of developing well-trained researchers who have the vision and skills with which to embark on successful careers in academic Gastroenterology. Dr. Richard Peek (Director of the VDDRC) serves as Program Director. He will be assisted by two Co-Associate Directors; Dr. Sari Acra, Director of the Division of Pediatric Gastroenterology and Dr. Keith Wilson, Director of the Adult Gastroenterology fellowship program as well as Internal and External Advisory Committees composed of senior faculty deeply invested in training young investigators. The program is designed to support postdoctoral fellows (M.D., M.D./Ph.D., Ph.D.) who show exceptional aptitude for successfully pursuing an academic career. Postdoctoral trainees will be selected from the pool of fellows accepted into the Adult and Pediatric GI training programs, physician-scientist applicants from various other clinical training programs at Vanderbilt and applicants that apply to preceptor laboratories. A customized mentoring team is constructed for each trainee consisting of a Mentor with nationally recognized expertise and a Research Advisory Committee to provide additional guidance, mentoring and feedback. The trainee's experience is enriched by interactions with other investigators and trainees in the VDDRC, an extensive program of seminars and conferences, and coursework tailored to meet individual needs. The unique environment that supports digestive disease research at Vanderbilt, consisting of rich collaborative interactions between basic and clinical researchers, a wide range of supporting VDDRC and non-VDDRC Cores and Centers, and exposure to state-of-the-art clinical care, provides an outstanding opportunity to train successful scientists whose discoveries regarding fundamental aspects of digestive diseases can be rapidly translated into improved patient care.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007673-22
Application #
8881144
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1992-07-01
Project End
2016-04-29
Budget Start
2015-07-01
Budget End
2016-04-29
Support Year
22
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37240
Martinez 2nd, Keith A; Romano-Keeler, Joann; Zackular, Joseph P et al. (2018) Bacterial DNA is present in the fetal intestine and overlaps with that in the placenta in mice. PLoS One 13:e0197439
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Schlegel, Cameron; Weis, Victoria G; Knowles, Byron C et al. (2018) Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease. Dig Dis Sci 63:356-365
Davenport, James R; Su, Timothy; Zhao, Zhiguo et al. (2018) Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps. Gut 67:456-465
Schlegel, Cameron; Greeno, Amber; Chen, Heidi et al. (2018) Evolution of a level I pediatric trauma center: Changes in injury mechanisms and improved outcomes. Surgery 163:1173-1177
Engevik, Amy C; Kaji, Izumi; Engevik, Melinda A et al. (2018) Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl- Secretion in Enterocytes. Gastroenterology 155:1883-1897.e10
Scoville, Elizabeth A; Allaman, Margaret M; Brown, Caroline T et al. (2018) Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics 14:
Kohl, Kevin D; Dearing, M Denise; Bordenstein, Seth R (2018) Microbial communities exhibit host species distinguishability and phylosymbiosis along the length of the gastrointestinal tract. Mol Ecol 27:1874-1883
Schlegel, Cameron; Lapierre, Lynne A; Weis, Victoria G et al. (2018) Reversible deficits in apical transporter trafficking associated with deficiency in diacylglycerol acyltransferase. Traffic 19:879-892
Woods, Stephen C; May-Zhang, Aaron A; Begg, Denovan P (2018) How and why do gastrointestinal peptides influence food intake? Physiol Behav 193:218-222

Showing the most recent 10 out of 84 publications