This is a competitive renewal application for a 15 year T32 program to train postdoctoral fellows in gastrointestinal basic scientific research by 19 highly selected interdisciplinary faculty mentors drawn from the Center for Gastrointestinal Biology and Disease (CGIBD). The primary goal of this program is to develop the future academic and scientific leaders of gastroenterology by training promising MD, MD/PhD, DVM/PhD and PhD postdoctoral fellows to become independent investigators. A diverse, extensive training program helps our trainees develop new insights into the pathogenesis of gastrointestinal diseases and perform basic and translational research to identify novel diagnostic and treatment approaches. We propose to continue supporting two new postdoctoral fellows each year for 2 years of full time lab-based research (total of four postdoctoral fellows/year). We recruit MD research gastroenterology fellows and PhD postdoctoral fellows, with an equal distribution of MD and PhD trainees. We have a comprehensive, interactive training program that integrates trainees of different backgrounds to broaden the educational experience of all participants. The effectiveness of this integrated training program is proven by results: 18 of our 24 trainees over the past 10 years have obtained academic positions or are currently continuing their training. We have filled our full complement of trainees for each year of funding with exceptionally well qualified investigators who are actively engaged in basic GI research under highly qualified mentors. Our T32 training program has undergone continued evolution since the last competitive renewal in 2006 that has improved our ability to prepare trainees for independent research careers. We have recruited Susan Henning, PhD as co-director after she moved to UNC in 2007 from Baylor College of Medicine, where she ran a highly effective Pediatric GI training program for 18 years. In addition, we have created a more cohesive program with more frequent interaction among the T32 trainees, a formal research committee for all MD trainees and a Mentor in Training program. Finally, we have appointed extremely talented trainees and maintained an equal balance between MD and PhD trainees over the past funding cycle. One incoming MD trainee is from an underrepresented racial group, showing our successful recruitment of minorities.

Public Health Relevance

This is a competitive renewal application for a 15 year T32 program to train postdoctoral fellows in gastrointestinal basic scientific research by 19 highly experienced interdisciplinary faculty mentors. The primary goal of this program is to develop the future academic and scientific leaders of gastroenterology by training promising MD, MD/PhD, DVM/PhD and PhD postdoctoral fellows to become independent investigators. A diverse, extensive training program helps our trainees develop new insights into the pathogenesis of gastrointestinal diseases and perform basic and translational research to identify novel diagnostic and treatment approaches. Relevance to Public Health Our comprehensively trained postdoctoral fellows are prepared to perform multidisciplinary research that can be applied to investigate basic pathogenesis of GI diseases and development of novel treatment and diagnostic approaches. Our Ph.D. and M.D. trainees are trained in laboratory based research, digestive disease pathogenesis and normal GI physiology, so that they can perform translational research relevant to important human gastrointestinal diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007737-17
Application #
8287621
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
1996-08-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
17
Fiscal Year
2012
Total Cost
$166,223
Indirect Cost
$17,618
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Harley, Isaac T W; Stankiewicz, Traci E; Giles, Daniel A et al. (2014) IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology 59:1830-9
Onyiah, Joseph C; Sheikh, Shehzad Z; Maharshak, Nitsan et al. (2014) Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota. Gut Microbes 5:220-4
Shanahan, Michael T; Carroll, Ian M; Grossniklaus, Emily et al. (2014) Mouse Paneth cell antimicrobial function is independent of Nod2. Gut 63:903-10
Maharshak, Nitsan; Packey, Christopher D; Ellermann, Melissa et al. (2013) Altered enteric microbiota ecology in interleukin 10-deficient mice during development and progression of intestinal inflammation. Gut Microbes 4:316-24
Arthur, Janelle C; Gharaibeh, Raad Z; Uronis, Joshua M et al. (2013) VSL#3 probiotic modifies mucosal microbial composition but does not reduce colitis-associated colorectal cancer. Sci Rep 3:2868
Cocchiaro, Jordan L; Rawls, John F (2013) Microgavage of zebrafish larvae. J Vis Exp :e4434
McKee, Robert W; Mangalea, Mihnea R; Purcell, Erin B et al. (2013) The second messenger cyclic Di-GMP regulates Clostridium difficile toxin production by controlling expression of sigD. J Bacteriol 195:5174-85
Gulati, Ajay S; Shanahan, Michael T; Arthur, Janelle C et al. (2012) Mouse background strain profoundly influences Paneth cell function and intestinal microbial composition. PLoS One 7:e32403
Sheikh, Shehzad Z; Kobayashi, Taku; Matsuoka, Katsuyoshi et al. (2011) Characterization of an interferon-stimulated response element (ISRE) in the Il23a promoter. J Biol Chem 286:1174-80
Kobayashi, Taku; Matsuoka, Katsuyoshi; Sheikh, Shehzad Z et al. (2011) NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J Immunol 186:4649-55

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