The objective of this continuation proposal is to train outstanding young M.D.s, M.D./Ph.D.s and Ph.D.s for a successful career in investigative Nephrology. The independent renal investigator of the future must be knowledgeable in cellular and molecular biology, immunology, molecular genetics, gene therapy, developmental biology, stem cell biology and basic virology. It is clear that future academic Nephrologists must receive rigorous basic research training for significant progress to be made in our understanding of the molecular and cellular processes involved in the development of renal diseases and therapeutic interventions to be developed. It is our belief that the most appropriate type of research environment, the requisite depth of training experience, and protection for a prolonged period of support for individuals who are starting their training can best be accomplished through a training grant. Our rationale for submitting this application for the continuation of our training grant is our belief that Mount Sinai School of Medicine offers diverse scientific opportunities in an outstanding research environment, that we have a faculty that is dedicated to training physician-scientists for a career in academic Nephrology, and that we would like to continue to contribute and have an impact on the education of future investigative Nephrologists.This training grant is in the ninth year of funding with a successful training track record, 93% of graduates remining in academics and 71% independently funded investigators. Continued support is being requested at the current level of 4 post-doctoral positions for a minimum of 2-years funding. An experienced group of 25 faculty provide trainees the opportunity to train in a variety of areas of research related to renal disease. Trainees will participate in an interactive environment with state of the art research facilities, and will participate in required courses, journal clubs, lab meetings and research conferences. An internal organizational structure and external advisory board are in place to supplement trainer supervision and to ensure that the program remains cutting edge and that trainees receive sufficient guidance to optimize their transition to independent investigators.

Public Health Relevance

(Seeinstructions): The need for investigators in the area of Nephrology is underscored by the growing number of Americans being diagnosed with Chronic Kidney Disease (CKD). It is estimated that there are in the order of 7.7 million adults with stage III or higher CKD. For the scientific community to impact this growing problem we need to be make substantial progress in our understanding of the disease processes that cause CKD and contribute to its progression,,so that we may develop therapeutic interventions that prevent the development of ESRD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
5T32DK007757-14
Application #
8300939
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
Project Start
1998-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$201,687
Indirect Cost
$14,784
Name
Icahn School of Medicine at Mount Sinai
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Nonnenmacher, Mathieu E; Cintrat, Jean-Christophe; Gillet, Daniel et al. (2015) Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction. J Virol 89:1673-87
Mallipattu, Sandeep K; Liu, Ruijie; Zhong, Yifei et al. (2013) Expression of HIV transgene aggravates kidney injury in diabetic mice. Kidney Int 83:626-34
Leventhal, Jeremy S; Schroppel, Bernd (2012) Toll-like receptors in transplantation: sensing and reacting to injury. Kidney Int 81:826-32
Mehrotra, Anita (2012) ESAs in transplant anemia: one size does not "fit all". J Am Soc Nephrol 23:192-3
Mallipattu, Sandeep K; Liu, Ruijie; Zheng, Feng et al. (2012) Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. J Biol Chem 287:19122-35
Mehrotra, Anita; Rose, Caren; Pannu, Neesh et al. (2012) Incidence and consequences of acute kidney injury in kidney transplant recipients. Am J Kidney Dis 59:558-65
Ingersoll, Molly A; Spanbroek, Rainer; Lottaz, Claudio et al. (2010) Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 115:e10-9
Dinavahi, Rajani; Heeger, Peter S (2008) T-cell immune monitoring in organ transplantation. Curr Opin Organ Transplant 13:419-24
Kuhnert, Frank; Campagnolo, Luisa; Xiong, Jing-Wei et al. (2005) Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol 283:140-56
Woda, Craig B; Miyawaki, Nobuyuki; Ramalakshmi, Santhanam et al. (2003) Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects. Am J Physiol Renal Physiol 285:F629-39

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