This application seeks support for the second renewal of a T32 Training Grant awarded to the Scott Department of Urology at Baylor College of Medicine. This established program has trained one predoctoral student, 6 Ph.D. and 3 M.D. fellows with an additional fellow currently in training. The research emphasis of this program is in the areas pediatric urology/genitourinary development, basic prostate biology, health services research and male reproductive biology. The training faculty includes 10 Ph.D/M.D., Ph.D. faculty and 4 M.D.s. Dr. Lamb will continue to serve as Program Director of the Fellowship training program. The major research areas in the program include: genetics and genomics of genitourinary developmental defects, prostate biology, cell biology, steroid hormone receptors and growth factor signaling, male reproductive biology, genetics, cell cycle control, human benign prostatic hyperplasia, gene therapy and gene disruption. The trainees will be Ph.D. and M.D. fellows and summer undergraduate students who participate in the Summer Medical and Research Training Program at Baylor (SMART Program). Our program attracts highly qualified trainees who seek intensive and substantial research training in urologic research with an emphasis on clinical translation. We have a defined recruitment plan that emphasizes the recruitment of women and minorities. The strengths of the training environment include highly respected, well-funded, experienced faculty, the high ranking national ranking for NIH funding of a Urology department, a structured mentoring program and required coursework, a cell biology graduate program with relevant course work and depth in both cell biology and genetics. Our long-term goal is to train these young investigators to successfully compete for peer-reviewed funding and eventually to increase basic and translational research efforts in Urology.

Public Health Relevance

Our goal is to continue to train new investigators to become urologic researchers. There is a significant need for advanced research in the areas of pediatric urology, male reproductive biology, health services research and benign prostatic disease. It is only through research advances that the field of urology will advance and continue to improve patient care.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Rankin, Tracy L
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Baylor College of Medicine
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United States
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Vital, Paz; Castro, Patricia; Tsang, Susan et al. (2014) The senescence-associated secretory phenotype promotes benign prostatic hyperplasia. Am J Pathol 184:721-31
Smith, Phillip P; Smith, Christopher P; Boone, Timothy B et al. (2007) Is abdominal wall contraction important for normal voiding in the female rat? BMC Urol 7:5
Agoulnik, Irina U; Vaid, Ajula; Nakka, Manjula et al. (2006) Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res 66:10594-602
Agoulnik, Irina U; Vaid, Ajula; Bingman 3rd, William E et al. (2005) Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression. Cancer Res 65:7959-67
Murthy, Shalini; Agoulnik, Irina U; Weigel, Nancy L (2005) Androgen receptor signaling and vitamin D receptor action in prostate cancer cells. Prostate 64:362-72
Castro, Patricia; Xia, Chen; Gomez, Lori et al. (2004) Interleukin-8 expression is increased in senescent prostatic epithelial cells and promotes the development of benign prostatic hyperplasia. Prostate 60:153-9
Lan, Zi-Jian; Xu, Xueping; Cooney, Austin J (2003) Generation of a germ cell nuclear factor conditional allele in mice. Genesis 37:172-9
Castro, Patricia; Giri, Dipak; Lamb, Dolores et al. (2003) Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate 55:30-8
Lan, Zi-Jian; Gu, Peili; Xu, Xueping et al. (2003) GCNF-dependent repression of BMP-15 and GDF-9 mediates gamete regulation of female fertility. EMBO J 22:4070-81
Lan, Zi-Jian; Gu, Peili; Xu, Xueping et al. (2003) Expression of the orphan nuclear receptor, germ cell nuclear factor, in mouse gonads and preimplantation embryos. Biol Reprod 68:282-9

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