This proposal seeks continuation of support for Cedars-Sinai's, """"""""Training Program in Endocrinology, Diabetes, and Metabolism"""""""". Consistent with the history of this program our goal is to train scientists to study thyroid, reproductive endocrinology, diabetes/metabolism, endocrine oncology, endocrine hypertension, and neuroendocrinology. Fifteen faculty members, from seven departments/institutes, including our Director, Shlomo Melmed, MD, represent these areas of research. Our faculty mentors are a strength of this program with over $33,796,659 million dollars in funding and 640 peer reviewed publications with trainees over the last ten years. This type of productivity has led to our fellow funded by this T32 publishing 134 peer- reviewed articles and 6 fellows obtaining NIH extramural funding since the inception of our training grant. We will continue this success with program improvements such as modified areas of research, improved program assessment and tracking, increased trainee recruitment (including underrepresented minorities), collaboration with Sanford- Burnham Medical Research Institute and addition of eight new faculty. A major faculty recruitment is Dr. Richard Bergman, an expert in obesity and diabetes and pioneer of the """"""""minimal model"""""""". We are requesting funding support for four postdoctoral positions.
Endocrinology related diseases are a major area of health concern for today's society. Cedars-Sinai's, Training Program in Endocrinology, Diabetes, and Metabolism addresses the specialized training of scientist in several areas of endocrinology research including but not limited to diabetes, obesity, cancer, and high blood pressure.
|Smith, Bethany N; Bhowmick, Neil A (2016) Role of EMT in Metastasis and Therapy Resistance. J Clin Med 5:|
|Araki, Takako; Liu, Ning-Ai; Tone, Yukiko et al. (2016) E2F1-mediated human POMC expression in ectopic Cushing's syndrome. Endocr Relat Cancer 23:857-870|
|Chesnokova, Vera; Zonis, Svetlana; Zhou, Cuiqi et al. (2016) Growth hormone is permissive for neoplastic colon growth. Proc Natl Acad Sci U S A 113:E3250-9|
|Giani, Jorge F; Shah, Kandarp H; Khan, Zakir et al. (2015) The intrarenal generation of angiotensin II is required for experimental hypertension. Curr Opin Pharmacol 21:73-81|
|Liu, Xiaohai; Kano, Maya; Araki, Takako et al. (2015) ErbB receptor-driven prolactinomas respond to targeted lapatinib treatment in female transgenic mice. Endocrinology 156:71-9|
|Liu, Ning-Ai; Araki, Takako; Cuevas-Ramos, Daniel et al. (2015) Cyclin E-Mediated Human Proopiomelanocortin Regulation as a Therapeutic Target for Cushing Disease. J Clin Endocrinol Metab 100:2557-64|
|Shah, Kandarp H; Shi, Peng; Giani, Jorge F et al. (2015) Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension. Circ Res 117:858-69|
|Ben-Shlomo, Anat; Mirocha, James; Gwin, Stephanie M et al. (2014) Clinical factors associated with biochemical adrenal-cortisol insufficiency in hospitalized patients. Am J Med 127:754-62|
|Giani, Jorge F; Janjulia, Tea; Kamat, Nikhil et al. (2014) Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition. J Am Soc Nephrol 25:2752-63|
|Bernstein, Kenneth E; Gonzalez-Villalobos, Romer A; Giani, Jorge F et al. (2014) Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response. Biol Chem 395:1173-8|
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