This application is a request for renewal of the Hematopoiesis Training Grant of the University of Pennsylvania. The program consists of 4 post-doctoral and 2pre-doctoral positions for training in aspects of normal and malignant hematopoiesis. We are requesting one additional pre-doctoral position of a M.D./Ph.D. candidate to meet the requests for additional opportunities for this group of trainees. The program currently has 21trainers with trainers added in the areas of malignant hematopoiesis and hematopoiesis of aging. The Hematopoiesis Training Program is a multi-disciplinary, cross departmental training program drawing on the extensive resources of the University of Pennsylvania School of Medicine, Children's Hospital of Pennsylvania and the Wistar Institute. The academicelements of the training program include a proven mixture of coursework, laboratory work, research presentations, thesis research, career development counseling and extramural conferences that combine to train new investigators in the fundamentals of blood development. The assembles trainers for this grant have extensive and highly productive training records in the area of hematopoiesis and substantial research support through both individual grants and program projects. These laboratories offer training opportunities across virtually all aspects ofhematopoietic cell development and function. The Hematopoiesis research group draws candidates from several graduate programs at the University of Pennsylvania and post-doctoral applicants Tom around the world. The program focuses specifically on training individuals to have a broad and deep understanding of the fundamentals of hematopoiesis with a goal of developing successful researchers in this important area of biology.

Public Health Relevance

Blood diseases are common disorders that affect all populations of the United States. This application will rain researchers to better understand how blood cells develop and generate new treatments for diseases of he blood and blood cells.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Bishop, Terry Rogers
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Campbell, Amy E; Hsiung, Chris C-S; Blobel, Gerd A (2014) Comparative analysis of mitosis-specific antibodies for bulk purification of mitotic populations by fluorescence-activated cell sorting. Biotechniques 56:90-1, 93-4
Valvezan, Alexander J; Huang, Jian; Lengner, Christopher J et al. (2014) Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech 7:63-71
Campbell, Amy E; Wilkinson-White, Lorna; Mackay, Joel P et al. (2013) Analysis of disease-causing GATA1 mutations in murine gene complementation systems. Blood 121:5218-27
Heinicke, Laurie A; Nabet, Behnam; Shen, Shihao et al. (2013) The RNA binding protein RBM38 (RNPC1) regulates splicing during late erythroid differentiation. PLoS One 8:e78031
Jiang, Jing; Balcerek, Joanna; Rozenova, Krasimira et al. (2012) 14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. J Clin Invest 122:2079-91
Zhao, Huiwu; Jin, Shenghao; Gewirtz, Alan M (2012) The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia. J Biol Chem 287:925-34
Lamonica, Janine M; Deng, Wulan; Kadauke, Stephan et al. (2011) Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proc Natl Acad Sci U S A 108:E159-68
Liu, Hudan; Chiang, Mark Y; Pear, Warren S (2011) Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia. Int J Hematol 94:118-25
Vishnu, Melanie R; Sumaroka, Marina; Klein, Peter S et al. (2011) The poly(rC)-binding protein alphaCP2 is a noncanonical factor in X. laevis cytoplasmic polyadenylation. RNA 17:944-56
Khwaja, Shariq S; Liu, Hudan; Tong, Caili et al. (2010) HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice. J Clin Invest 120:2537-48

Showing the most recent 10 out of 15 publications