The goal of this continuation Gastroenterology Research Training Program proposal is to prepare M.D., Ph.D., or M.D./Ph.D. postdoctoral fellows for careers as independent investigators in academic Gastroenterology. A diverse, experienced faculty will provide the opportunity to learn contemporary methods of cellular and molecular biology or clinical research by mentorship in one of five broad areas: A) Injury, Fibrosis Signaling &Gene Regulation;B) Cancer Biology &Genetics;C) Immunology and Virology;D) Molecular Basis of Metabolism, Development &Stem cells;or E) Patient-oriented Clinical Investigation in Hepatobililary and Gastrointestinal Diseases. The training will provide a solid foundation for future success in investigative Gastroenterology. To do so, expert faculty have been recruited from the Divisions of Gastroenterology, Liver Diseases, Nephrology, Hematology/Oncology, Infectious Diseases, Clinical Immunology and Endocrinology, and from two other Departments and six Research Institutes and Centers. Trainees will enter the program from one of four sources: 1) Following completion of least 18 months of clinical Gastroenterology fellowship at the Mount Sinai School of Medicine;2) Following completion of a clinical Gastroenterology fellowship plus a year of clinical Hepatology at the Mount Sinai School of Medicine;3) After the awarding of a Ph.D. degree in life sciences, or 4) Following completion of a Medicine Residency for exceptional candidates. Trainee candidates will devote a minimum of two years to training in either laboratory- or patient-based research. Each year this grant will continue support 3 trainees at the PGY 4 - PGY 6 level. The strong productivity and academic career choices of the grant's trainees to date reinforce the success of this 10 yr-old program. At least 90% of trainees'time will be devoted to working in the laboratory or clinical setting on an individualized research project under the guidance of faculty mentor(s). In addition, all trainees participate in weekly laboratory or clinical group meetings, attend relevant divisional, departmental and institutional research-oriented conferences, and enroll in specifically designed coursework in laboratory or clinical investigative methods. This integrated proposal emphasizing translational research will train future academic leaders in investigative gastroenterology. Such training will be essential to enable advances in the care of tens of million Americans affected by gastrointestinal and hepatobiliary diseases, including new approaches to the clinical management of affected patients through rigorous training.

Public Health Relevance

The enlarging burden of gastrointestinal and liver diseases requires accomplished scientists who can make fundamental discoveries of pathogenesis and translate them into new treatments. This integrated proposal emphasizing translational research will train future academic leaders in investigative gastroenterology who can enable advances in the care of tens of million Americans affected by gastrointestinal and hepatobiliary diseases, including new approaches to the clinical management of affected patients through rigorous training.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK007792-11
Application #
8267985
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2001-05-01
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
11
Fiscal Year
2012
Total Cost
$98,904
Indirect Cost
$9,067
Name
Icahn School of Medicine at Mount Sinai
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Mosoian, Arevik; Zhang, Lumin; Hong, Feng et al. (2017) Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS. J Leukoc Biol 101:1083-1090
Cohen, Louis J; Esterhazy, Daria; Kim, Seong-Hwan et al. (2017) Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature 549:48-53
Bollard, Julien; Miguela, Verónica; Ruiz de Galarreta, Marina et al. (2017) Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma. Gut 66:1286-1296
Shtraizent, Nataly; DeRossi, Charles; Nayar, Shikha et al. (2017) MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. Elife 6:
Wooden, Benjamin; Goossens, Nicolas; Hoshida, Yujin et al. (2017) Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases. Gastroenterology 152:53-67.e3
Klepper, Arielle; Eng, Francis J; Doyle, Erin H et al. (2017) Hepatitis C virus double-stranded RNA is the predominant form in human liver and in interferon-treated cells. Hepatology 66:357-370
Hicks, Daniel F; Goossens, Nicolas; Blas-García, Ana et al. (2017) Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. Sci Rep 7:42563
Tovar, Victoria; Cornella, Helena; Moeini, Agrin et al. (2017) Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma. Gut 66:530-540
Abou-Alfa, Ghassan K; Andersen, Jesper B; Chapman, William et al. (2016) Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference. J Gastrointest Oncol 7:819-827
Chu, John; Vila-Farres, Xavier; Inoyama, Daigo et al. (2016) Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat Chem Biol 12:1004-1006

Showing the most recent 10 out of 42 publications