This is an application to renew support for the Baylor College of Medicine (BCM) Hematology Training Program (HTP) that has been successfully running for 10 years and has trained, or is training, 41 young investigators, 11 of whom are from under-represented minority groups. Of past trainees, 13 are academic faculty performing biomedical research and 16 are still in training. The trainees have published a total of 107 papers directly related to their hematology training. The overall goal of the Hematology Training Program is to foster hematology research by training the most talented young investigators at the pre-doc and post-doc level. Training is provided to researchers in both adult and pediatric hematology who include MD, MD/PhD and PhD trainees, as well as basic researchers performing hematology-related research in diverse departments. The BCM HTP provides its trainees with the mentorship, research skills and experience to ultimately become productive and successful investigators in the field. The program is structured to ensure close mentorship from accomplished senior researchers at Baylor College of Medicine, and to support junior faculty to develop their own mentorship skills. The 33 faculty mentors participating in the HTP have broad teaching and training experience and share a commitment to train young scientists and physician-scientists in hematology research. Their expertise covers a wide range of hematology research areas including stem cell biology, hemoglobin function, iron metabolism, thrombosis, neutrophil function, myeloid cell differentiation, stem cell transplantation and cell and gene therapy. Important components of the BCM HTP are a structured training scheme involving mentored research, a didactic program, and preparation for grant writing. The PI and Co-Directors, Margaret Goodell, David Poplack, and Martha Mims have a history of close productive interaction with each other and a strong record of past trainees, assuring a close interaction and integration of basic research with clinical adult and pediatric hematology programs. Renewal of the Hematology Training Program will ensure continued training of outstanding physician-scientists in hematology at BCM.

Public Health Relevance

This program is designed to train young investigators to conduct hematology-related research. Trainees may conduct basic or translational research, with a view to entering a career in academic biomedical research and impacting the course of diseases related to hematology.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK060445-11
Application #
8666971
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Bishop, Terry Rogers
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77030
Rajagopal, Abbhirami; Braslavsky, D├ębora; Lu, James T et al. (2014) Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis. J Clin Endocrinol Metab 99:E2451-6
Ando, M; Hoyos, V; Yagyu, S et al. (2014) Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity. Cancer Gene Ther 21:472-82
Ho, Shiuh-Rong; Mahanic, Christina S; Lee, Yu-Ju et al. (2014) RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Proc Natl Acad Sci U S A 111:E2646-55
Challen, Grant A; Sun, Deqiang; Mayle, Allison et al. (2014) Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell 15:350-64
Doherty, Joseph E; Woodard, Lauren E; Bear, Adham S et al. (2013) An adaptable system for improving transposon-based gene expression in vivo via transient transgene repression. FASEB J 27:3753-62
Varnado, Cornelius L; Mollan, Todd L; Birukou, Ivan et al. (2013) Development of recombinant hemoglobin-based oxygen carriers. Antioxid Redox Signal 18:2314-28
Flanagan, Jonathan M; Sheehan, Vivien; Linder, Heidi et al. (2013) Genetic mapping and exome sequencing identify 2 mutations associated with stroke protection in pediatric patients with sickle cell anemia. Blood 121:3237-45
He, Jin; Shen, Li; Wan, Ma et al. (2013) Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol 15:373-84
Kettlun, Claudia; Galvan, Daniel L; George Jr, Alfred L et al. (2011) Manipulating piggyBac transposon chromosomal integration site selection in human cells. Mol Ther 19:1636-44
Berg, Jonathan S; Lin, Kuanyin K; Sonnet, Corinne et al. (2011) Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One 6:e26410

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