The number of young physicians choosing a career as a physician-scientist has declined dramatically over the last thirty years. To address this deficiency, we established an intense three-year laboratory-based training program, referred to as the Physician- Scientist Research Training Program (PSTRP), at the University of California, San Diego, School of Medicine. The program is specifically designed for physicians who have completed their clinical training, with no clinical obligations during the research training. The first class entered the program in June of 2000, and by several criteria, the program has been highly successful: of the 19 trainees who have completed the program, 11 have appointments in academia or the biotechnology community, four are on track to be promoted to Associate Professor within the next year, and together they have published 163 papers, or 8.6 papers per trainee. Sixteen faculty members, including two from the Salk Institute, serve as research mentors with their research areas corresponding to those of the mission of the National Institute of Diabetes and Digestive and Kidney Diseases. The faculty members are highly experienced, well- funded investigators with a strong track record for serving as a research mentor. The present proposal requests continuation of the program with two training positions at each level, for a total of six training positions.

Public Health Relevance

Physician-scientists play an important role in biomedical research, but for a variety of reasons, including lack of structured research training, the number of physicians pursuing a scientific career is limited. We have had a Physician- Scientist Research Training Program at the University of California, San Diego, School of Medicine for the last 10 years. The program trains physicians to conduct rigorous basic science research, and we are now requesting to renew the program for five more years.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Institutional National Research Service Award (T32)
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Study Section
Digestive Diseases and Nutrition C Subcommittee (DDK)
Program Officer
Rys-Sikora, Krystyna E
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University of California San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
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Selamet, Umut; Tighiouart, Hocine; Sarnak, Mark J et al. (2016) Relationship of dietary phosphate intake with risk of end-stage renal disease and mortality in chronic kidney disease stages 3-5: The Modification of Diet in Renal Disease Study. Kidney Int 89:176-84
Jiang, Jingjing; Chan, Adriano; Ali, Sameh et al. (2016) Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep 6:20831
Samraj, Annie N; Pearce, Oliver M T; Läubli, Heinz et al. (2015) A red meat-derived glycan promotes inflammation and cancer progression. Proc Natl Acad Sci U S A 112:542-7
Chan, Adriano; Jiang, Jingjing; Fridman, Alla et al. (2015) Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection. J Med Chem 58:1750-9
Schwarz, Flavio; Pearce, Oliver M T; Wang, Xiaoxia et al. (2015) Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife 4:
Pearce, Oliver M T; Samraj, Annie N; Läubli, Heinz et al. (2015) Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens. Proc Natl Acad Sci U S A 112:E1405
Goldenstein, Leonard; Driver, Todd H; Fried, Linda F et al. (2014) Serum bicarbonate concentrations and kidney disease progression in community-living elders: the Health, Aging, and Body Composition (Health ABC) Study. Am J Kidney Dis 64:542-9
Samraj, Annie N; Läubli, Heinz; Varki, Nissi et al. (2014) Involvement of a non-human sialic Acid in human cancer. Front Oncol 4:33
Bai, Hongdong; Nangia, Samir; Parmer, Robert J (2012) The plasminogen activation system and the regulation of catecholaminergic function. J Biomed Biotechnol 2012:721657
Jung, Andre Scott; Kaushansky, Alexis; Macbeath, Gavin et al. (2011) Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle 10:1838-44

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