Transplantation holds the promise of reversing the clinical course of millions of Americans afflicted with end- stage organ failure, including a number of gastro-intestinal (GI) diseases. However, a number of issues limit broader access to transplantation and various complications related to the need for lifetime immunosuppression affect the long-term success of transplantation. Thus, the long-term objective of the Transplant Surgery Scientist Training Program (TSSTP) is to foster and support inter-dependent transplant research in order improve outcomes for patients in need of transplantation. We will leverage scientific advances in the life sciences across academic disciplines, and focus these on advancing transplantation, directly and indirectly improving the health of patients in need of GI organs, consistent with the mission of NIDDK. We will train the next generation of postdoctoral scientists (PhDs) and clinician scientists (MDs) in surgery and GI medicine who will advance the field of transplantation, preferably as team scientists.
The specific aims of the TSSTP are 1) to educate trainees about the nature of existing barriers both to higher access to, and lower complications from transplantation, and 2) to arm them with a deep knowledge of state-of- the art tools, methodologies, and scientific approaches that can potentially be used to overcome these barriers. Significant `cross-talk' exists in clinical transplantation, thus, we will apply a training program that utilizes the Modular Approach to Transplant Research by Inter-disciplinary eXperts (MATRIX), a model that espouses the concept of inter-dependent team science and research between disciplines. This training model will be deployed across 2 separate training tracks that include 1) basic and translational scientific research within the Northwestern University Collaborative for Transplant Research in Immunobiology and Biomedical Engineering (NUCTRIBE), and 2) health sciences and outcomes research within the Northwestern University Transplant Outcomes Research Collaborative (NUTORC), and implement these in our second funding cycle. A total of 3 trainees will benefit for 2 years each from a customized MATRIX that will incorporate multidisciplinary co- mentoring. Each project must have a direct link to transplantation surgery, and the anchoring discipline in each MATRIX is a transplant clinician. The tactical objectives of this T32 are to: 1) provide stipend support for trainees; 2) provide multi-level, inter-disciplinary mentorship bringing together transplant clinician-scientists and non-clinician-scientists with state-of-the research methodologists; 3) protect trainees from clinical activities that compete for their time; 4) sustain an administrative structure that enhances both the quality and diversity of the candidate pool and trainees; 5) provide training opportunities that span the spectrum from both basic/translational science (NUCTRIBE) to clinical/health services and outcomes research (NUTORC) at their intersection with clinical transplantation; and 6) continue an ongoing evaluation process for determining whether or not the program is meeting its goals and objectives.

Public Health Relevance

Transplantation holds the promise of reversing the clinical course of millions of Americans afflicted with end- stage organ failure, including a number of gastro-intestinal (GI) diseases, but its broader application is limited by access to, and complications related to these life-saving procedures. The long-term objective of the Transplant Surgery Scientist Training Program (TSSTP), consistent with that of the Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32), is to train the next generation of investigators who, by leveraging scientific advances in the life sciences across academic disciplines, will advance the field of transplantation through team science. By fostering and supporting the training of inter-dependent transplant research, we will directly and indirectly improve the health of patients in need GI organs, consistent with the mission of NIDDK.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Institutional National Research Service Award (T32)
Project #
2T32DK077662-11
Application #
9280087
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Densmore, Christine L
Project Start
2007-07-01
Project End
2022-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
11
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Surgery
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Atiemo, K; Skaro, A; Maddur, H et al. (2017) Mortality Risk Factors Among Patients With Cirrhosis and a Low Model for End-Stage Liver Disease Sodium Score (?15): An Analysis of Liver Transplant Allocation Policy Using Aggregated Electronic Health Record Data. Am J Transplant 17:2410-2419
Zheng, Zhikun; Chiu, Stephen; Akbarpour, Mahzad et al. (2017) Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction. Sci Transl Med 9:
McCarthy, Derrick P; Yap, Jonathan Woon-Teck; Harp, Christopher T et al. (2017) An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy. Nanomedicine 13:191-200
Misharin, Alexander V; Morales-Nebreda, Luisa; Reyfman, Paul A et al. (2017) Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med 214:2387-2404
Bharat, Ankit; Chiu, Stephen; Zheng, Zhikun et al. (2016) Lung-Restricted Antibodies Mediate Primary Graft Dysfunction and Prevent Allotolerance after Murine Lung Transplantation. Am J Respir Cell Mol Biol 55:532-541
McElroy, Lisa M; Khorzad, Rebeca; Nannicelli, Anna P et al. (2016) Failure mode and effects analysis: a comparison of two common risk prioritisation methods. BMJ Qual Saf 25:329-36
Savaryn, John Paul; Skinner, Owen S; Fornelli, Luca et al. (2016) Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry. J Proteomics 134:76-84
Fernandez, Ramiro; Chiu, Stephen; Raparia, Kirtee et al. (2016) Humoral Human Lung Allograft Rejection by Tissue-Restricted Non-HLA Antibodies. Ann Thorac Surg 102:e339-41
Patzer, Rachel E; Serper, Marina; Reese, Peter P et al. (2016) Medication understanding, non-adherence, and clinical outcomes among adult kidney transplant recipients. Clin Transplant 30:1294-1305
Chiu, Stephen; Fernandez, Ramiro; Subramanian, Vijay et al. (2016) Lung Injury Combined with Loss of Regulatory T Cells Leads to De Novo Lung-Restricted Autoimmunity. J Immunol 197:51-7

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