The University of Pittsburgh seeks continued support for our multidisciplinary and innovative pre-doctoral training in Regenerative Medicine via Cellular Approaches to Tissue Engineering and Regeneration (CATER) training program. The CATER program combines faculty and research expertise from a diverse group of disciplines that combine tissue engineering with molecular and cellular approaches of therapies for human disease and regeneration. Regenerative medicine is truly an interdisciplinary field that brings together scientists from human biology, engineering, medical devices, material sciences, medicine and applied technologies to focus on the repair and replacement of human tissues. One of the most significant challenges in regenerative medicine is developing the next generation of experts in each of the enabling disciplines that must be trained cognizant of the cross-disciplinary challenges and approaches required for successful practice of regenerative medicine. To address this issue we developed the CATER pre-doctoral training program to fill the gaps that often exist in more traditional departmentally-focused research training programs. The goal of the CATER training program is to provide a solid foundation upon which to build a productive and independent career in regenerative medicine for human disease and injury. This goal is accomplished via a highly coordinated and mentored interdisciplinary training program that traverses departments and disciplines, and combines required and elective courses, research and specialized training opportunities. Our history (10-years of funding support) provides evidence that we are accomplishing our training objectives and generating successful scientists. The evolving definition of success for CATER program is recapitulated by the career choices of the past trainees that in essence demonstrates their preparedness and demand, fulfilling the timely need of experts in the area of regenerative medicine in both academics and industry. As CATER program moves into its 10th year, we now appreciate the maturation of the field of regenerative medicine such that a broad variety of technologies are seeking to be commercialized to cross into the area of reimbursable clinical care. As we propose the program for the next five years, we continue to build on our strengths and concurrently embrace the timely concepts and paradigms integral to regenerative medicine today. Our evolving curricula in the program reflects these exciting times and embodies the proverbial concepts of bench to bedside, academic entrepreneurship and translational medicine through rigorous partnerships with the Clinical and Translational Science Institute, the Coulter program and the Office of Technology Management. We thus propose to continue, as a team, train a new generation of scientists practicing regenerative medicine through coordinated, interdisciplinary and rigorous didactic and research training via the CATER program.

Public Health Relevance

The University of Pittsburgh pre-doctoral training program in Cellular Approaches to Tissue Engineering and Regeneration educates and trains the next generation of scientists in regenerative medicine. Our multidisciplinary training creates researchers who can provide new therapies for diseases through regenerative medicine.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
2T32EB001026-11
Application #
8665067
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Baird, Richard A
Project Start
2003-07-01
Project End
2019-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Zupanc, Heidi R H; Alexander, Peter G; Tuan, Rocky S (2017) Neurotrophic support by traumatized muscle-derived multipotent progenitor cells: Role of endothelial cells and Vascular Endothelial Growth Factor-A. Stem Cell Res Ther 8:226
Saldin, Lindsey T; Cramer, Madeline C; Velankar, Sachin S et al. (2017) Extracellular matrix hydrogels from decellularized tissues: Structure and function. Acta Biomater 49:1-15
Brown, Bryan N; Haschak, Martin J; Lopresti, Samuel T et al. (2017) Effects of age-related shifts in cellular function and local microenvironment upon the innate immune response to implants. Semin Immunol 29:24-32
Rothrauff, Benjamin B; Shimomura, Kazunori; Gottardi, Riccardo et al. (2017) Anatomical region-dependent enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix. Acta Biomater 49:140-151
White, Lisa J; Taylor, Adam J; Faulk, Denver M et al. (2017) The impact of detergents on the tissue decellularization process: A ToF-SIMS study. Acta Biomater 50:207-219
Yang, Guang; Rothrauff, Benjamin B; Lin, Hang et al. (2017) Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-?3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells. Tissue Eng Part A 23:166-176
Hachim, Daniel; Wang, Na; Lopresti, Samuel T et al. (2017) Effects of aging upon the host response to implants. J Biomed Mater Res A 105:1281-1292
Bayer, Emily A; Fedorchak, Morgan V; Little, Steven R (2016) The Influence of Platelet-Derived Growth Factor and Bone Morphogenetic Protein Presentation on Tubule Organization by Human Umbilical Vascular Endothelial Cells and Human Mesenchymal Stem Cells in Coculture. Tissue Eng Part A 22:1296-1304
Nuschke, Austin; Rodrigues, Melanie; Rivera, Jaime et al. (2016) Epidermal Growth Factor Tethered to ?-Tricalcium Phosphate Bone Scaffolds via a High-Affinity Binding Peptide Enhances Survival of Human Mesenchymal Stem Cells/Multipotent Stromal Cells in an Immune-Competent Parafascial Implantation Assay in Mice. Stem Cells Transl Med 5:1580-1586
Dearth, Christopher L; Slivka, Peter F; Stewart, Scott A et al. (2016) Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury. Acta Biomater 31:50-60

Showing the most recent 10 out of 81 publications