The field of microfluidics is uniquely poised to make a broad impact in biomedical sciences through the miniaturization and mass parallelization of biological experimentation. For example, future advances in microfluidics could revolutionize disease diagnosis, drug discovery, and pathogen detection. For these impacts to be realized we need individuals conversant in engineering, chemistry, biology, and medical sciences. Currently however, such cross-trained people are in short supply. To address this shortage, we propose a five-year program to train the next generation of biomedical microfluidics experts. This program combines the expertise of faculty from engineering, chemistry, physics, and the medical school plus the world-class Solid State Electronics Laboratory (SSEL) for state-of-the-art micro- and nanofabrication. The premise of the program is that students should have significant training in both the methods of microfluidics and in the biomedical applications of this technology. Such training enhances the communication between disciplines, identification of solvable biomedical and clinical problems, and selection of appropriate tools to solve these problems. The training of the students in this program will involve a combination of course work, seminar series, hands-on workshop, annual symposium, journal club, and cross-disciplinary lab rotation or collaboration. All of these activities are beyond the requirements of the trainee's home department. The core course for this program "Microfluidic Science and Engineering" has been taught for several years with success. The seminar and workshop were originally developed by graduate students independent of the training program showing the enthusiasm of the graduate students for this topic. We feel that this combination of practical teaching, cross- disciplinary exposure, and intensive microfluidic study will produce students well positioned to answer the growing need for highly educated and trained microfluidics experts.

Public Health Relevance

This application seeks to train scientists and engineers to utilize microfluidic technology for application to biomedical science. Microfluidics enables control of fluids at micron dimensions. The technology has potential for improving healthcare through many application areas including diagnostics, enabling new research, and drug discovery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB005582-08
Application #
8306804
Study Section
Special Emphasis Panel (ZEB1-OSR-C (M1))
Program Officer
Baird, Richard A
Project Start
2005-09-30
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$262,720
Indirect Cost
$12,879
Name
University of Michigan Ann Arbor
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Syverud, Brian C; VanDusen, Keith W; Larkin, Lisa M (2016) Growth Factors for Skeletal Muscle Tissue Engineering. Cells Tissues Organs 202:169-179
Guetschow, Erik D; Kumar, Surinder; Lombard, David B et al. (2016) Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples. Anal Bioanal Chem 408:721-31
Caschera, Filippo; Lee, Jin Woo; Ho, Kenneth K Y et al. (2016) Cell-free compartmentalized protein synthesis inside double emulsion templated liposomes with in vitro synthesized and assembled ribosomes. Chem Commun (Camb) 52:5467-9
Oliver, C Ryan; Gourgou, Eleni; Bazopoulou, Daphne et al. (2016) On-Demand Isolation and Manipulation of C. elegans by In Vitro Maskless Photopatterning. PLoS One 11:e0145935
Lee, Lap Man; Lee, Jin Woo; Chase, Danielle et al. (2016) Development of an advanced microfluidic micropipette aspiration device for single cell mechanics studies. Biomicrofluidics 10:054105
Syverud, Brian C; VanDusen, Keith W; Larkin, Lisa M (2016) Effects of Dexamethasone on Satellite Cells and Tissue Engineered Skeletal Muscle Units. Tissue Eng Part A 22:480-9
Kim, Sejoong; LesherPerez, Sasha Cai; Kim, Byoung Choul C et al. (2016) Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip. Biofabrication 8:015021
Tan, Xinyu; Heureaux, Johanna; Liu, Allen P (2015) Cell spreading area regulates clathrin-coated pit dynamics on micropatterned substrate. Integr Biol (Camb) 7:1033-43
Moraes, Christopher; Labuz, Joseph M; Shao, Yue et al. (2015) Supersoft lithography: candy-based fabrication of soft silicone microstructures. Lab Chip 15:3760-5
Horger, Kim S; Liu, Haiyan; Rao, Divya K et al. (2015) Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes. Biochim Biophys Acta 1848:643-53

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