The field of microfluidics is uniquely poised to make a broad impact in biomedical sciences through the miniaturization and mass parallelization of biological experimentation. For example, future advances in microfluidics could revolutionize disease diagnosis, drug discovery, and pathogen detection. For these impacts to be realized we need individuals conversant in engineering, chemistry, biology, and medical sciences. Currently however, such cross-trained people are in short supply. To address this shortage, we propose a five-year program to train the next generation of biomedical microfluidics experts. This program combines the expertise of faculty from engineering, chemistry, physics, and the medical school plus the world-class Solid State Electronics Laboratory (SSEL) for state-of-the-art micro- and nanofabrication. The premise of the program is that students should have significant training in both the methods of microfluidics and in the biomedical applications of this technology. Such training enhances the communication between disciplines, identification of solvable biomedical and clinical problems, and selection of appropriate tools to solve these problems. The training of the students in this program will involve a combination of course work, seminar series, hands-on workshop, annual symposium, journal club, and cross-disciplinary lab rotation or collaboration. All of these activities are beyond the requirements of the trainee's home department. The core course for this program """"""""Microfluidic Science and Engineering"""""""" has been taught for several years with success. The seminar and workshop were originally developed by graduate students independent of the training program showing the enthusiasm of the graduate students for this topic. We feel that this combination of practical teaching, cross- disciplinary exposure, and intensive microfluidic study will produce students well positioned to answer the growing need for highly educated and trained microfluidics experts.

Public Health Relevance

This application seeks to train scientists and engineers to utilize microfluidic technology for application to biomedical science. Microfluidics enables control of fluids at micron dimensions. The technology has potential for improving healthcare through many application areas including diagnostics, enabling new research, and drug discovery.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB005582-08
Application #
8306804
Study Section
Special Emphasis Panel (ZEB1-OSR-C (M1))
Program Officer
Baird, Richard A
Project Start
2005-09-30
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$262,720
Indirect Cost
$12,879
Name
University of Michigan Ann Arbor
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Labuz, Joseph M; Moraes, Christopher; Mertz, David R et al. (2017) Building an experimental model of the human body with non-physiological parameters. Technology (Singap World Sci) 5:42-59
Ho, Kenneth K Y; Lee, Jin Woo; Durand, Grégory et al. (2017) Protein aggregation with poly(vinyl) alcohol surfactant reduces double emulsion-encapsulated mammalian cell-free expression. PLoS One 12:e0174689
Decker, Joseph T; Hobson, Eric C; Zhang, Yining et al. (2017) Systems analysis of dynamic transcription factor activity identifies targets for treatment in Olaparib resistant cancer cells. Biotechnol Bioeng 114:2085-2095
Ramamurthy, Poornapriya; White, Joshua B; Yull Park, Joong et al. (2017) Concomitant differentiation of a population of mouse embryonic stem cells into neuron-like cells and schwann cell-like cells in a slow-flow microfluidic device. Dev Dyn 246:7-27
Spinosa, Phillip C; Luker, Kathryn E; Luker, Gary D et al. (2017) The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue. PLoS One 12:e0187357
Syverud, Brian C; VanDusen, Keith W; Larkin, Lisa M (2016) Growth Factors for Skeletal Muscle Tissue Engineering. Cells Tissues Organs 202:169-179
Caschera, Filippo; Lee, Jin Woo; Ho, Kenneth K Y et al. (2016) Cell-free compartmentalized protein synthesis inside double emulsion templated liposomes with in vitro synthesized and assembled ribosomes. Chem Commun (Camb) 52:5467-9
Oliver, C Ryan; Gourgou, Eleni; Bazopoulou, Daphne et al. (2016) On-Demand Isolation and Manipulation of C. elegans by In Vitro Maskless Photopatterning. PLoS One 11:e0145935
Jordahl, Jacob H; Villa-Diaz, Luis; Krebsbach, Paul H et al. (2016) Engineered Human Stem Cell Microenvironments. Curr Stem Cell Rep 2:73-84
Ferguson, Stephen A; Wang, Xuewei; Meyerhoff, Mark E (2016) Detecting Levels of Polyquaternium-10 (PQ-10) via Potentiometric Titration with Dextran Sulphate and Monitoring the Equivalence Point with a Polymeric Membrane-Based Polyion Sensor. Anal Methods 8:5806-5811

Showing the most recent 10 out of 54 publications