The Interdisciplinary Biomedical Imaging Training Program will prepare predoctoral trainees to become leaders in organism-level, biomedical imaging research. Multi-disciplinary teams of engineers, physicists, biologists, and clinicians are required to advance biomedical imaging, especially with the advent of in vivo cellular and molecular imaging. We will create the next generation of interdisciplinary biomedical imaging scientists and engineers who will contribute to and lead such teams. Our training program will build upon continuing, significant institutional, state, federal, and commercial investment in faculty and imaging infrastructure. A training grant award will place students squarely in the center of on-going interdisciplinary/multidisciplinary research programs. Trainees will use imaging facilities in the Case Center for Imaging Research which includes state-of- the-art clinical and small animal imaging systems, along with labs of mentoring faculty. Predoctoral trainees will be from the highly-rated departments of Biomedical Engineering and Physics, both of which have a long history of training in biomedical imaging. Trainees will conduct research projects combining enabling technologies in imaging with biomedical research. Each trainee will have two or more mentors representing both imaging technology and biological/clinical applications of imaging. Our educational program includes a portfolio of imaging courses, including ones focusing on imaging physics, image analysis, and reconstruction, as well as Cellular and Molecular Imaging and Nanomedicine (Nanosized Therapeutics and Imaging Agents), a new course specially designed for interdisciplinary training in nanoparticle theranostics. We will promote a culture of inter- disciplinary research in a series of diverse activities during a designated Imaging Hour. Training funds are mostly used to recruit first year graduate students, a significant need at our institution. Our T32 has enabled us to increase recruitment of women and under-represented minorities. In general, it has helped make graduate students cost effective as compared to post docs and ensured training of domestic PhD's in this area of critical need. In less than four years, our T32 program has already successfully trained four graduates, all with exemplary training records and with a trajectory towards success. Other trainees are moving through the program focusing on exciting interdisciplinary imaging research and with excellent research productivity.

Public Health Relevance

Biomedical imaging enables early detection, assessment of therapy, and minimally-invasive treatment of disease. Especially with the advent of cellular and molecular imaging, biomedical imaging research requires persons with strong interdisciplinary training.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Institutional National Research Service Award (T32)
Project #
5T32EB007509-07
Application #
8464700
Study Section
Special Emphasis Panel (ZEB1-OSR-E (J2))
Program Officer
Baird, Richard A
Project Start
2007-09-01
Project End
2017-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
7
Fiscal Year
2013
Total Cost
$270,838
Indirect Cost
$13,191
Name
Case Western Reserve University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Evans, Teresa A; Barkauskas, Deborah S; Myers, Jay T et al. (2014) High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Exp Neurol 254:109-20
Wright, Katherine L; Hamilton, Jesse I; Griswold, Mark A et al. (2014) Non-Cartesian parallel imaging reconstruction. J Magn Reson Imaging 40:1022-40
Toy, Randall; Peiris, Pubudu M; Ghaghada, Ketan B et al. (2014) Shaping cancer nanomedicine: the effect of particle shape on the in vivo journey of nanoparticles. Nanomedicine (Lond) 9:121-34
Wright, Katherine L; Harrell, Michael W; Jesberger, John A et al. (2014) Clinical evaluation of CAIPIRINHA: comparison against a GRAPPA standard. J Magn Reson Imaging 39:189-94
Evans, Teresa A; Barkauskas, Deborah S; Myers, Jay T et al. (2014) Intravital imaging of axonal interactions with microglia and macrophages in a mouse dorsal column crush injury. J Vis Exp :e52228
Shukla, Sourabh; Wen, Amy M; Ayat, Nadia R et al. (2014) Biodistribution and clearance of a filamentous plant virus in healthy and tumor-bearing mice. Nanomedicine (Lond) 9:221-35
Peiris, Pubudu M; Toy, Randall; Abramowski, Aaron et al. (2014) Treatment of cancer micrometastasis using a multicomponent chain-like nanoparticle. J Control Release 173:51-8

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