This is a renewal application to the NIBIB for continuing our "broad-based" post-doctoral training program in cardiovascular (CV) imaging. CV disease remains the leading cause of morbidity and mortality in the US, yet there are unmet needs in detecting and characterizing CV disease and monitoring/guiding therapy. There are now a multitude of CV imaging technologies and disciplines involved in CV research, from the molecular to clinical level, requiring future generations of CV imaging researchers to have dedicated multi- disciplinary training.
Aim : Continue to bring together trainees and mentors from three core and complementary areas - engineering, molecular imaging, and clinical imaging - for a structured two-year research and educational program in CV imaging. Trainees: Four (4) post-doctoral fellows, with balance of MD and PhD backgrounds from all three of the above areas, who train over a two-year period. Mentors: Twenty-one (21) Stanford faculty mentors - half with MDs and three-quarters with PhDs - who are engaged in CV imaging research. Both the School of Medicine and the School of Engineering are well represented, including Cardiovascular Medicine, Radiology/Radiological Sciences, Electrical Engineering/Bioengineering, and the Molecular Imaging Program at Stanford (MIPS). Training Program: Research - two years of research in CV imaging under a primary mentor, with a secondary mentor from a complementary discipline (e.g., MD to complement PhD). Education - Structured program consisting of courses and seminars in 1) Multi-Modality Cardiovascular Imaging, 2) Cardiovascular Imaging Frontiers, 3) Multi-Disciplinary Innovation, and 4) Research Career Development. Environment: Stanford has a strong environment of innovation and technology-based CV imaging research, with NIH-funded programs and numerous facilities in the Schools of Medicine and Engineering, plus additional support from the Cardiovascular Institute and the Center for Biomedical Imaging at Stanford. Impact: We have successfully brought together a broad range of trainees and faculty mentors/co-mentors across Schools/Departments, 1st group in 2009 and 2nd group in 2011. Of the 8 initial trainees, 4 have garnered Assistant Professor or Instructor positions, 3 are continuing in cardiology or post-doctoral fellowship, and 1 is in biomedical industry. Our goal is to continue this innovative program to train the next generation of CV imaging investigators.

Public Health Relevance

This training program is relevant to public health as it centers on the study of heart disease, which remains the most serious medical problem in the US. In particular, this program will foster the training and career development of physicians, scientists, and engineers in the field of heart and blood vessel imaging, which is critical for detecting this important disease and guiding therapies to improve patient outcomes.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32EB009035-06A1
Application #
8667215
Study Section
Special Emphasis Panel (ZEB1)
Program Officer
Baird, Richard A
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Stanford
State
CA
Country
United States
Zip Code
94304
Zaman, Raiyan T; Kosuge, Hisanori; Pratx, Guillem et al. (2014) Fiber-optic system for dual-modality imaging of glucose probes 18F-FDG and 6-NBDG in atherosclerotic plaques. PLoS One 9:e108108
Mordwinkin, Nicholas M; Lee, Andrew S; Wu, Joseph C (2013) Patient-specific stem cells and cardiovascular drug discovery. JAMA 310:2039-40
McConnell, Michael V; Wu, Holden H (2013) Respiratory-mode display of echocardiographic images highlights effects of pericardial disease. JACC Cardiovasc Imaging 6:917-9
Lam, Mai T; Nauta, Allison; Meyer, Nathaniel P et al. (2013) Effective delivery of stem cells using an extracellular matrix patch results in increased cell survival and proliferation and reduced scarring in skin wound healing. Tissue Eng Part A 19:738-47
Wu, Holden H; Gurney, Paul T; Hu, Bob S et al. (2013) Free-breathing multiphase whole-heart coronary MR angiography using image-based navigators and three-dimensional cones imaging. Magn Reson Med 69:1083-93