Application is made for continued funding of a long-standing programassociated withthe Center in Molecular Toxicology at Vanderbilt University. Funds are requested to support eight predoctoral trainees (Ph.D. candidates) and six postdoctoral trainees (those having a Ph.D., M.D., D.V.M., etc.). This interdisciplinary program emphasizes molecular aspects of toxicology related to environmental health. The faculty is drawn from individuals with appointments in Biochemistry, Biological Sciences, Chemistry, Medicine, Pathology, Pediatrics, and Pharmacology, all of whom train postdoctoral fellows. Graduate students in the program obtain degrees through Biochemistry, Biological Sciences, Chemistry, Pathology, or Pharmacology. Considerable emphasis is placed upon research rotations, the thesis research itself, and participation in seminars, journal clubs, and joint research meetings. There is also much opportunity for learning operation and application of instrumental systems in research. Graduate students are recruited to the Departments of Biological Sciences and Chemistry through departmental mechanisms, with assistance from the Center in Molecular Toxicology. In the other three (biomedical) departments, graduate students are initially recruited into either the Interdisciplinary Graduate Program or the Chemical and Physical Biology Program, where they spend the first 9 months in a relatively common core curriculum and do four laboratory rotations. Graduate students are recruited into Toxicology from these first year pools (theinitial year is supported by the institution). Both predoctoral and postdoctoral trainees are selected by the Center's Steering Committee, with guidelines to ensure distribution of trainees and monitoring of progress. The list of preceptors includes twenty-two faculty who are all Center Investigators. Major research areas in the Center include oxidative damage, DMA damage and genetic instability, maintenance of genomic integrity, enzymatic biotransformation and reactions of electrophiles, and neurotoxicology. Molecular toxicology is recognized as a strong program, and the institution has continued its commitment to making Vanderbilt a leading center for training in this area.

Public Health Relevance

This interdisciplinary program has a long-standing and successful history of training individuals in the molecular aspects of environmental toxicology. Many former trainees of the program have gone on to productive careers in academia, industry, and government institutes. Pre- and postdoctoraltrainees receive a strong background in basic science with opportunities to participate in clinical and translational research. The ultimate goal of this program is to train future scientists in areas relevant to improving human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007028-39
Application #
8501451
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1975-07-10
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
39
Fiscal Year
2013
Total Cost
$595,959
Indirect Cost
$40,219
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Albertolle, Matthew E; Kim, Donghak; Nagy, Leslie D et al. (2017) Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition. J Biol Chem 292:11230-11242
Johnson, Kevin M; Phan, Thanh T N; Albertolle, Matthew E et al. (2017) Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol. J Biol Chem 292:13672-13687
Gonzalez, Eric; Guengerich, F Peter (2017) Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1. J Biol Chem 292:13168-13185
Gnecco, Juan S; Pensabene, Virginia; Li, David J et al. (2017) Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium. Ann Biomed Eng 45:1758-1769
Wages, Phillip A (2017) Detecting Protein Sulfenylation in Cells Exposed to a Toxicant. Curr Protoc Toxicol 71:17.18.1-17.18.12
Aron, Allegra T; Heffern, Marie C; Lonergan, Zachery R et al. (2017) In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A 114:12669-12674
Mullins, Elwood A; Shi, Rongxin; Eichman, Brandt F (2017) Toxicity and repair of DNA adducts produced by the natural product yatakemycin. Nat Chem Biol 13:1002-1008
Galligan, James J; Kingsley, Philip J; Wauchope, Orrette R et al. (2017) Quantitative Analysis and Discovery of Lysine and Arginine Modifications. Anal Chem 89:1299-1306
Bruner-Tran, Kaylon L; Gnecco, Juan; Ding, Tianbing et al. (2017) Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models. Reprod Toxicol 68:59-71
Mullins, Elwood A; Warren, Garrett M; Bradley, Noah P et al. (2017) Structure of a DNA glycosylase that unhooks interstrand cross-links. Proc Natl Acad Sci U S A 114:4400-4405

Showing the most recent 10 out of 253 publications