Funds are requested to support eight pre-doctoral (Ph.D. candidates) and six postdoctoral trainees in the Training Program in Environmental Toxicology, the long-standing training component of the Center in Molecular Toxicology at Vanderbilt University. This interdisciplinary program provides research career training in molecular aspects of toxicology related to environmental health. Because the field is inherently interdisciplinary, research training in the program spans chemistry, biochemistry, chemical biology, structural biology, analytical technology, functional genomics, pathogen-host interactions, disease pathology, and exposure science. The faculty preceptors have appointments in the departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, Medicine, Neurology, Pathology/Microbiology/Immunology, Pediatrics, and Pharmacology, all of whom train doctoral students and postdoctoral fellows. Training is achieved through basic and specialized coursework, research rotations, dissertation research, and participation in seminars, journal clubs, and joint research meetings. A distinctive feature of the Program is hands-on training on diverse technology platforms through a highly developed and open system of research facility cores at Vanderbilt. Graduate students are recruited to the Department of Chemistry through departmental mechanisms, with assistance from the Center in Molecular Toxicology. In the medical school departments, graduate students are initially recruited into either the Interdisciplinary Graduate Program in Biomedical and Biological Sciences or the Quantitative and Chemical Biology Program, where they spend the first 9 months in a common core curriculum and do laboratory rotations. Graduate students are supported for the first year by these programs. Students then are recruited into the Training Program in Environmental Toxicology from these first-year pools, and training program support begins in the second year. Both pre-doctoral and postdoctoral trainees are selected by the Training Program Advisory Committee, with guidelines to ensure distribution of trainees and monitoring of progress. The list of preceptors includes 18 faculty members who are all Investigators in the Center in Molecular Toxicology. Major research areas in the Center include oxidative damage, DNA damage and repair, maintenance of genomic integrity, enzymatic biotransformation and reactions of electrophiles, neurotoxicology, respiratory disease pathophysiology, systems biology, and pathogen-host interactions. Graduates from the program have been highly successful in academia, industry, and other professional settings and include leaders in the field.

Public Health Relevance

This interdisciplinary program has a long-standing and successful history of training scientists for careers in molecular toxicology as applied to environmental health. The trainees have gone on to productive careers in academia, industry, and government institutes. Trainees receive a strong, broad background in basic science with opportunities to specialize in specific sub-disciplines of basic and translational research.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32ES007028-40
Application #
8666611
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
40
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Brinkhaus, Sigrid Grosse; Bornhorst, Julia; Chakraborty, Sudipta et al. (2014) Elemental bioimaging of manganese uptake in C. elegans. Metallomics 6:617-21
Bornhorst, Julia; Chakraborty, Sudipta; Meyer, Sören et al. (2014) The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of ?-synuclein in C. elegans. Metallomics 6:476-90
Mason, Aaron C; Rambo, Robert P; Greer, Briana et al. (2014) A structure-specific nucleic acid-binding domain conserved among DNA repair proteins. Proc Natl Acad Sci U S A 111:7618-23
Carroll, Clinton; Bansbach, Carol E; Zhao, Runxiang et al. (2014) Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity. Nucleic Acids Res 42:918-25
Galligan, James J; Rose, Kristie L; Beavers, William N et al. (2014) Stable histone adduction by 4-oxo-2-nonenal: a potential link between oxidative stress and epigenetics. J Am Chem Soc 136:11864-6
Yoshimoto, Francis K; Guengerich, F Peter (2014) Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase. J Am Chem Soc 136:15016-25
Lamberson, Connor R; Xu, Libin; Muchalski, Hubert et al. (2014) Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. J Am Chem Soc 136:838-41
Caito, Samuel; Zeng, Heng; Aschner, Judy L et al. (2014) Methylmercury alters the activities of Hsp90 client proteins, prostaglandin E synthase/p23 (PGES/23) and nNOS. PLoS One 9:e98161
Zhao, Linlin; Pence, Matthew G; Eoff, Robert L et al. (2014) Elucidation of kinetic mechanisms of human translesion DNA polymerase ? using tryptophan mutants. FEBS J 281:4394-410
Frank, Andreas O; Vangamudi, Bhavatarini; Feldkamp, Michael D et al. (2014) Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem 57:2455-61

Showing the most recent 10 out of 178 publications