Funds are requested to support eight pre-doctoral (Ph.D. candidates) and six postdoctoral trainees in the Training Program in Environmental Toxicology, the long-standing training component of the Center in Molecular Toxicology at Vanderbilt University. This interdisciplinary program provides research career training in molecular aspects of toxicology related to environmental health. Because the field is inherently interdisciplinary, research training in the program spans chemistry, biochemistry, chemical biology, structural biology, analytical technology, functional genomics, pathogen-host interactions, disease pathology, and exposure science. The faculty preceptors have appointments in the departments of Biochemistry, Biological Sciences, Biomedical Informatics, Chemistry, Medicine, Neurology, Pathology/Microbiology/Immunology, Pediatrics, and Pharmacology, all of whom train doctoral students and postdoctoral fellows. Training is achieved through basic and specialized coursework, research rotations, dissertation research, and participation in seminars, journal clubs, and joint research meetings. A distinctive feature of the Program is hands-on training on diverse technology platforms through a highly developed and open system of research facility cores at Vanderbilt. Graduate students are recruited to the Department of Chemistry through departmental mechanisms, with assistance from the Center in Molecular Toxicology. In the medical school departments, graduate students are initially recruited into either the Interdisciplinary Graduate Program in Biomedical and Biological Sciences or the Quantitative and Chemical Biology Program, where they spend the first 9 months in a common core curriculum and do laboratory rotations. Graduate students are supported for the first year by these programs. Students then are recruited into the Training Program in Environmental Toxicology from these first-year pools, and training program support begins in the second year. Both pre-doctoral and postdoctoral trainees are selected by the Training Program Advisory Committee, with guidelines to ensure distribution of trainees and monitoring of progress. The list of preceptors includes 18 faculty members who are all Investigators in the Center in Molecular Toxicology. Major research areas in the Center include oxidative damage, DNA damage and repair, maintenance of genomic integrity, enzymatic biotransformation and reactions of electrophiles, neurotoxicology, respiratory disease pathophysiology, systems biology, and pathogen-host interactions. Graduates from the program have been highly successful in academia, industry, and other professional settings and include leaders in the field.

Public Health Relevance

This interdisciplinary program has a long-standing and successful history of training scientists for careers in molecular toxicology as applied to environmental health. The trainees have gone on to productive careers in academia, industry, and government institutes. Trainees receive a strong, broad background in basic science with opportunities to specialize in specific sub-disciplines of basic and translational research.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Schools of Medicine
United States
Zip Code
Camarillo, Jeannie M; Rose, Kristie L; Galligan, James J et al. (2016) Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression. Chem Res Toxicol 29:323-32
Federspiel, Joel D; Codreanu, Simona G; Palubinsky, Amy M et al. (2016) Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress. Mol Cell Proteomics 15:1947-61
Shimada, Tsutomu; Takenaka, Shigeo; Murayama, Norie et al. (2016) Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13. Xenobiotica 46:211-24
Parsons, Zachary D; Bland, Joshua M; Mullins, Elwood A et al. (2016) A Catalytic Role for C-H/Ï€ Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD. J Am Chem Soc 138:11485-8
Nairn, Brittany L; Lonergan, Zachery R; Wang, Jiefei et al. (2016) The Response of Acinetobacter baumannii to Zinc Starvation. Cell Host Microbe 19:826-36
Yoshimoto, Francis K; Auchus, Richard J (2016) Rapid kinetic methods to dissect steroidogenic cytochrome P450 reaction mechanisms. J Steroid Biochem Mol Biol 161:13-23
Nguyen, Thuy T; Caito, Samuel W; Zackert, William E et al. (2016) Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7. Aging (Albany NY) 8:1759-80
Bruner-Tran, Kaylon L; Gnecco, Juan; Ding, Tianbing et al. (2016) Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models. Reprod Toxicol :
Kramlinger, Valerie M; Nagy, Leslie D; Fujiwara, Rina et al. (2016) Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids. FEBS Lett 590:1304-12
Federspiel, Joel D; Codreanu, Simona G; Goyal, Sandeep et al. (2016) Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells. Mol Cell Proteomics 15:3233-3242

Showing the most recent 10 out of 235 publications