During the past 30 years, over 300 students have received instruction in the toxicological sciences Toxicology Training from this program. Among our trainees were 18 who received Master's degrees, 102 who received Ph.D. degrees, 139 postdoctoral fellow, and 55 medical students (short-term trainees). Contained in this proposal is a request for five additional years of funding for this Toxicology Training Program (TTP). In support of this, details are provided on recruiting and retaining students, including minority fellows. Also included are changes in the program over the past decade including modifications in and modernization of the curriculum. Thanks to continued institutional support, the past decade has witnessed changes in the TTP to modernize the training, to improve recruitment, to streamline and update courses, to increase the number of participating faculty, and to enhance student exposure to outside leaders and opportunities in the field, and the recruitment of 18 faculty in the Department of Pharmacology, Toxicology, and Therapeutics (DPTT), and with the plan to hire another seven faculty over the next five years. In addition, faculty from other basic science departments have been added to the program as well as a number of clinical researchers and the development of a Liver Center to increase the translational aspects of the training program. Therefore, the program is positioned to maintain its international reputation as a Center of Excellence for training in toxicology.
Chemicals are present in the air we breathe, as well as in the food and water that we drink. Research is needed to understand how these chemicals produce their toxic effects, so we can protect and treat these adverse effects. This program will train the next generation of toxicologists to perform these essential roles.
|Zamek-Gliszczynski, Maciej J; Mohutsky, Michael A; Rehmel, Jessica L F et al. (2014) Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk. Drug Metab Dispos 42:1008-15|
|Vermeer, Lydia M M; Gregory, Eugene; Winter, Michelle K et al. (2014) Exposure to bisphenol A exacerbates migraine-like behaviors in a multibehavior model of rat migraine. Toxicol Sci 137:416-27|
|Xie, Yuchao; McGill, Mitchell R; Dorko, Kenneth et al. (2014) Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol 279:266-74|
|McGill, Mitchell R; Cao, Mengde; Svetlov, Archie et al. (2014) Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans. Biomarkers 19:222-30|
|Du, Kuo; Williams, C David; McGill, Mitchell R et al. (2014) Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. Toxicol Appl Pharmacol 281:58-66|
|Williams, Jessica A; Manley, Sharon; Ding, Wen-Xing (2014) New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases. World J Gastroenterol 20:12908-33|
|Li, Yuan; Wang, Shaogui; Ni, Hong-Min et al. (2014) Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. Biomed Res Int 2014:498491|
|Williams, C David; Bajt, Mary Lynn; Sharpe, Matthew R et al. (2014) Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans. Toxicol Appl Pharmacol 275:122-33|
|McGill, Mitchell R; Staggs, Vincent S; Sharpe, Matthew R et al. (2014) Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome. Hepatology 60:1336-45|
|Williams, C David; McGill, Mitchell R; Lebofsky, Margitta et al. (2014) Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning. Toxicol Appl Pharmacol 274:417-24|
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