Abstract

The aim of this program is to train postdoctoral fellows in mechanistic approaches (at the cellular and molecular levels) for investigating the role of environmental factors in mutagenesis and carcinogenesis. The major part of the training program consists of a research apprenticeship of postdoctoral trainees with one of 18 faculty preceptors (usually for three years). The proposal is to continue training a steady state level of 12 postdoctorals. The areas of research are concentrated on the basic mechanisms involved in tissue injury, mutagenesis and carcinogenesis, DNA damage and repair, chromosomal instability, DNA and protein structure, cytogenetic, cell cycle regulation, tissue remodeling, embryology, differentiation and development. This direct, laboratory based research training is supplemented by the following: seminars at LREH and other parts of UCSF; topical short courses given by some of the LREH faculty in the areas of Recombination, Radiation Biology, and DNA repair; journal clubs, a biweekly Research Conference for all trainees and preceptors; and the potential to take basic graduate level courses, as needed. M.D. trainees are required to attend two summer courses in Molecular Biology and Cell Biology offered as part of an introduction to research by the UCSF Molecular Medicine Program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007106-19
Application #
6150690
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1982-07-01
Project End
2002-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
19
Fiscal Year
2000
Total Cost
$214,346
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Latimer, Jean J; Majekwana, Vongai J; Pabón-Padín, Yashira R et al. (2015) Regulation and disregulation of mammalian nucleotide excision repair: a pathway to nongermline breast carcinogenesis. Photochem Photobiol 91:493-500
Chao, Richard C; Pyzel, Urszula; Fridlyand, Jane et al. (2005) Therapy-induced malignant neoplasms in Nf1 mutant mice. Cancer Cell 8:337-48
Curtiss, Nicole P; Bonifas, Jeannette M; Lauchle, Jennifer O et al. (2005) Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. Genomics 85:600-7
Pfendler, Kristina C; Catuar, Carmina S; Meneses, Juanito J et al. (2005) Overexpression of Nodal promotes differentiation of mouse embryonic stem cells into mesoderm and endoderm at the expense of neuroectoderm formation. Stem Cells Dev 14:162-72
Chang, C; Werb, Z (2001) The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis. Trends Cell Biol 11:S37-43
Zitzelsberger, H; Bruch, J; Smida, J et al. (2001) Clonal chromosomal aberrations in simian virus 40-transfected human thyroid cells and in derived tumors developed after in vitro irradiation. Int J Cancer 96:166-77
Fung, J; Weier, H U; Pedersen, R A (2001) Detection of structural and numerical chromosome abnormalities in interphase cells using spectral imaging. J Histochem Cytochem 49:797-8
Weier, H; Munne, S; Lersch, R A et al. (2001) Towards a full karyotype screening of interphase cells: 'FISH and chip' technology. Mol Cell Endocrinol 183 Suppl 1:S41-5
Fung, J; Weier, H U; Goldberg, J D et al. (2000) Multilocus genetic analysis of single interphase cells by spectral imaging. Hum Genet 107:615-22
Lersch, R A; Fung, J; Munne, S et al. (2000) Case-specific, breakpoint-spanning DNA probes for analysis of single interphase cells. Genet Test 4:273-8

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