The NIEHS Training Program in Environmental Health Sciences is in its thirtieth year and has supported 57 current and former pre-doctoral and 26 current and former postdoctoral trainees since 2003. Thirty-seven former pre-doctoral and twenty-one former postdoctoral trainees are in career positions in the private sector/industry, government or academia. There are currently 15 pre-doctoral and 7 postdoctoral trainees. Combined, current and former trainees have published over 280 peer-reviewed papers and book chapters. The need for this Training Program arises directly from the vision statement for the NIEHS that is being refined in the new 2012 Strategic Plan to ... "provide global leadership for innovative research that improves public health by preventing disability and disease from our environment". At the core for the implementation of this vision is the need to "recruit and train the next generation of environmental health scientists". The Johns Hopkins Training Program is uniquely situated to make important contributions to the national efforts of NIEHS to achieve this vision by being anchored within the large, multidisciplinary Hopkins School of Public Health. In this renewal application, based on the foci of research of the training faculty, the investigators have framed the Training Program into three areas: Molecular Mechanisms of Toxicity;Environmental Epidemiology/Exposure Sciences and Translational Toxicology. Within these three broad areas, the research being conducted by the faculty together with their pre- and postdoctoral trainees addresses one or more of the following topics: a) Mechanisms of disease pathobiology;b) Development and application of biomarkers of the pathobiology (e.g. biomarkers of response, effect, susceptibility);c) Development of prevention intervention and translational strategies;and, d) Environmental disease epidemiology. Within these areas, the research addresses a number of diseases to which environmental exposures contribute including cancer, COPD, asthma, CVD and neurodegenerative diseases. The Program is both interdisciplinary and interdepartmental. Training faculty members involved in the current application are from the Departments of Environmental Health Sciences (EHS), Biochemistry and Molecular Biology, in the School of Public Health and from the School of Medicine's Departments of Oncology and Comparative Medicine. All hold primary or joint appointments in EHS. In this renewal application the investigators are requesting 15 pre-doctoral positions and 4 postdoctoral positions.
The Training Program is directly relevant to the health burden of environmental exposures on people living in the U.S. and throughout the world. The mission of this Training Program is to provide the academic and research foundation for graduate and post-graduate scientists to become future leaders of interdisciplinary research projects that seek to understand the role that environmental exposures play in the etiology and exacerbation of human disease and apply this knowledge to develop prevention and intervention strategies. The Program prepares trainees to be the next generation of environmental health researchers who will set and address the nation's environmental health research agenda with the goal of reducing incidence, morbidity, recurrence, and mortality, and the disparities in diseases including cancer, COPD, cardiovascular disease and neurological disorders.
|Zhu, Hao; Bouhifd, Mounir; Donley, Elizabeth et al. (2016) Supporting read-across using biological data. ALTEX 33:167-82|
|Luechtefeld, Thomas; Maertens, Alexandra; Russo, Daniel P et al. (2016) Analysis of public oral toxicity data from REACH registrations 2008-2014. ALTEX 33:111-22|
|Clive, Makena L; Boks, Marco P; Vinkers, Christiaan H et al. (2016) Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model. Clin Epigenetics 8:113|
|Ball, Nicholas; Cronin, Mark T D; Shen, Jie et al. (2016) Toward Good Read-Across Practice (GRAP) guidance. ALTEX 33:149-66|
|Casey, Joan A; Savitz, David A; Rasmussen, Sara G et al. (2016) Unconventional Natural Gas Development and Birth Outcomes in Pennsylvania, USA. Epidemiology 27:163-72|
|Luechtefeld, Thomas; Maertens, Alexandra; Russo, Daniel P et al. (2016) Analysis of publically available skin sensitization data from REACH registrations 2008-2014. ALTEX 33:135-48|
|Loth, Meredith K; Choi, Judy; McGlothan, Jennifer L et al. (2016) TSPO in a murine model of Sandhoff disease: presymptomatic marker of neurodegeneration and disease pathophysiology. Neurobiol Dis 85:174-86|
|Christianson, Mindy S; Gerolstein, Amanda L; Lee, Hyo J et al. (2016) Effects of Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) inhibition on sperm incorporation and cortical tension in mouse eggs. Mol Reprod Dev 83:188-9|
|Osborne, Lauren; Clive, Makena; Kimmel, Mary et al. (2016) Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels. Neuropsychopharmacology 41:1648-58|
|Exum, Natalie G; Pisanic, Nora; Granger, Douglas A et al. (2016) Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings. Curr Environ Health Rep 3:322-34|
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