This proposal is to renew Environmental Carcinogenesis and Mutagenesis (T32 ES-09250-20). It is a fairly large training program due to an NIEHS-directed merger of two smaller training programs, one in toxicology and the other with a more genetic bent. ThePrcjgram has retained its diverse research interests, which has proven extremely valuable. Trainees withtoxicc>logy backgrounds discuss research genetics or molecular biology. The consequence has been an inevital)le cross-fertilizationof ideas and approaches. The major emphasis of the program remains the impact of environmental exposure on the genesis of disease, particularly cancer and pulmonary dysfunction, using molecular, genetic and toxicological approaches, Participating faculty derive from six different deoartments, including the Departments of Cell and Cancer Biology, Environmental Health, Molecular Genetics, Genome Sciences, Surgery and Dermatology, Nationally, the Program fulfills a need to train individuals at the pre- and postdoctoral levels in disciplines relating to biological, oncological and toxicological consequences of environmental exposure. Institutionally, the Program has brought research efforts of sei/eral laboratories into a common focus in areas of exposure and environmental health, and has facilitatedccjllaborative efforts between these laboratories. Thus, the Program encourages trainees to engage in restjarch that combines the expertise of several laboratories, These interactions are facilitated by our biweekly journal club meetings where trainees alternatively present a topical paper or present their data. Our interd sciplinary approach provides the trainees with a broader- based background than is otherwise available, Predoctoral trainees all have the equivalent of an undergraduate major in a chemical, biological cr physical science with superior academic achievements and many have won awards and recognition while iti theprogram. Postdoctoral candidates are selected based on proven academic accomplishments and hole1 the degrees of Ph.D., D.V.M. or M.D. Pre- and postdoctoral trainees are selected from a national pool of applicants. This renewal application requests predoctoral (8) and postdoctoral (4) positions. This programmatic size is optimal for the number of preceptors, the number of departments, and the extensive resources avai able to the trainees.

Public Health Relevance

Understanding environmental contributions to cancer rates requires cross-training in environmental health sciences, toxicology methods, and mechanisms of mutation. This program will train graduate students and post-doctoral fellows, giving them the expertise they need to make advances in the fields of environment and cancer, ultimately leading to a better understanding of environmental contributions to human disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007250-25
Application #
8500267
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1988-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
25
Fiscal Year
2013
Total Cost
$573,379
Indirect Cost
$32,991
Name
University of Cincinnati
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Premkumar, Vidjaya Letchoumy; Cranert, Stacey; Linger, Benjamin R et al. (2014) The 3' overhangs at Tetrahymena thermophila telomeres are packaged by four proteins, Pot1a, Tpt1, Pat1, and Pat2. Eukaryot Cell 13:240-5
Tuttle, Traci R; Hugo, Eric R; Tong, Wilson S et al. (2014) Placental lactogen is expressed but is not translated into protein in breast cancer. PLoS One 9:e87325
Torella, Rubben; Li, Jinghua; Kinrade, Eddie et al. (2014) A combination of computational and experimental approaches identifies DNA sequence constraints associated with target site binding specificity of the transcription factor CSL. Nucleic Acids Res 42:10550-63
Bittencourt, Fabiola M; Wu, Shu-En; Bridges, James P et al. (2014) The M33 G protein-coupled receptor encoded by murine cytomegalovirus is dispensable for hematogenous dissemination but is required for growth within the salivary gland. J Virol 88:11811-24
Tichy, Elisia D; Stephan, Zachary A; Osterburg, Andrew et al. (2013) Mouse embryonic stem cells undergo charontosis, a novel programmed cell death pathway dependent upon cathepsins, p53, and EndoG, in response to etoposide treatment. Stem Cell Res 10:428-41
Jin, Chang; Chen, Jing; Meng, Qinghang et al. (2013) Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis. Dev Biol 374:96-107
Doerdelmann, Thomas; Kojetin, Douglas J; Baird-Titus, Jamie M et al. (2012) Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant. Biochemistry 51:665-76
Doerdelmann, Thomas; Kojetin, Douglas J; Baird-Titus, Jamie M et al. (2012) ýýH, ýýýýC and ýýýýýN chemical shift assignments for the human Pitx2 homeodomain in complex with a 22-base hairpin DNA. Biomol NMR Assign 6:79-81
Doerdelmann, Thomas; Kojetin, Douglas J; Baird-Titus, Jamie M et al. (2011) 1H, 13C and 15N chemical shift assignments for the human Pitx2 homeodomain and a R24H homeodomain mutant. Biomol NMR Assign 5:105-7
Tichy, Elisia D; Liang, Li; Deng, Li et al. (2011) Mismatch and base excision repair proficiency in murine embryonic stem cells. DNA Repair (Amst) 10:445-51

Showing the most recent 10 out of 101 publications