The objective of this pre-doctoral and postdoctoral Training Program is to educate a new generation of environmental pathologists to use the tools of cell biology, biochemistry, molecular biology, and systems biology to study basic mechanisms of disease related to environmental exposures. The central focus is an independent laboratory research project to explore the pathogenesis of altered reproductive function, adverse developmental and pregnancy outcomes, the metabolic syndrome, and cancer resulting from exposure to industrial wastes and environmental contaminants including metals, plasticizers, pesticides, particulates, nanomaterials, and PAHs. Support is requested for 6 pre-doctoral trainees enrolled in the Pathobiology Graduate Program at Brown University and for 3 postdoctoral trainees for up to three years. Pre-doctoral trainees will be recruited with majors in biology, chemistry, toxicology or environmental sciences and a commitment to basic research on mechanisms of disease and environmental health. Postdoctoral trainees may hold doctoral degrees in a basic science discipline, pathology, or toxicology. All trainees are required to learn the basic mechanisms and morphologic manifestations of human disease. Training is also provided in molecular pathology, imaging, environmental toxicology, signal transduction, carcinogenesis, and biostatistics. All trainees will be instructed in the responsible conduct of research and will have the opportunity to develop their communication and teaching skills at the Sheridan Center for Teaching and Learning at Brown University. Didactic courses are supplemented by weekly research seminars, student journal clubs, career development and grantsmanship workshops, and annual retreats. Opportunities are provided for clinical and translational research collaborations at Rhode Island Hospital and Women &Infants'Hospital, as well as field work and community outreach at existing industrial waste sites and Brownfields in Rhode Island. The 14 faculty have active, well-funded research programs supported by 27 active research grants, 3 training grants, 2 COBRE grants, an NIEHS P42 Superfund Research Grant, a P20 Formative Center Grant, and a pilot project from the National Children's Study. Trainees have access to modern research facilities equipped for quantitative imaging, laser capture microdissection, genomics and proteomics, flow cytometry, transgenic animals, and human tissue and specimen banks. These trainees will be prepared to apply their basic research expertise to the definition, analysis, and solution of complex environmental health problems working together with experts in epidemiology, toxicology, public health, and government regulatory agencies. Public Health Relevance: This is an integrated interdisciplinary educational and research Training Program for pre-doctoral and postdoctoral trainees at Brown University and its affiliated hospitals. These trainees will apply state-of-the-art scientific tools to study basic mechanisms of human disease related to environmental exposures. Upon completion of this Training Program, these trainees will be prepared to identify, analyze, and solve complex environmental health problems working with interdisciplinary teams in universities, medical schools, industry, and government and regulatory agencies.

Public Health Relevance

This is an integrated interdisciplinary educational and research Training Program for pre-doctoral and postdoctoral trainees at Brown University and its affiliated hospitals. These trainees will apply state-of-the-art scientific tools to study basic mechanisms of human disease related to environmental exposures. Upon completion of this Training Program, these trainees will be prepared to identify, analyze, and solve complex environmental health problems working with interdisciplinary teams in universities, medical schools, industry, and government and regulatory agencies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007272-22
Application #
8501457
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
1992-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
22
Fiscal Year
2013
Total Cost
$430,271
Indirect Cost
$24,761
Name
Brown University
Department
Pathology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Dere, Edward; Anderson, Linnea M; Huse, Susan M et al. (2018) Effects of continuous bisphenol A exposure from early gestation on 90?day old rat testes function and sperm molecular profiles: A CLARITY-BPA consortium study. Toxicol Appl Pharmacol 347:1-9
Patel, Mohak; Leggett, Susan E; Landauer, Alexander K et al. (2018) Rapid, topology-based particle tracking for high-resolution measurements of large complex 3D motion fields. Sci Rep 8:5581
Valentin, Thomas M; Leggett, Susan E; Chen, Po-Yen et al. (2017) Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics. Lab Chip 17:3474-3488
Rodd, April L; Messier, Norma J; Vaslet, Charles A et al. (2017) A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures. Aquat Toxicol 186:134-144
Foster, Melanie L; Bartnikas, Thomas B; Maresca-Fichter, Hailey C et al. (2017) Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure. Data Brief 15:908-915
Dai, M S; Hall, S J; Vantangoli Policelli, M M et al. (2017) Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Andrology 5:1141-1152
Leggett, Susan E; Khoo, Amanda S; Wong, Ian Y (2017) Multicellular tumor invasion and plasticity in biomimetic materials. Biomater Sci 5:1460-1479
Leggett, Susan E; Wong, Ian Y (2017) Nanomedicine: Catching tumour cells in the zone. Nat Nanotechnol 12:191-193
Francois-Vaughan, Heather; Adebayo, Adeola O; Brilliant, Kate E et al. (2016) Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma. Carcinogenesis 37:408-419
Borgas, Diana; Chambers, Eboni; Newton, Julie et al. (2016) Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. Am J Respir Cell Mol Biol 54:683-96

Showing the most recent 10 out of 108 publications