Environmental agents play a significant role in the development of human disease. The identification of such toxicants and understanding their causal role in disease can rapidly be used in risk assessment and management and holds enormous promise in terms of therapeutic and clinical scenarios. This application requests funds to continue NYU's training program in environmental and molecular toxicology. The training will address a broad spectrum of problems in environmental health, from the causative molecular mechanisms of cancer, cardiopulmonary diseases, and other environmentally-related disorders to the development of animal models which may be used for predicting the adverse effects of environmental agents on human health. The major strength of the proposed toxicology training program is the outstanding quality and diversity of the training faculty, which will provide 4 pre-doctoral and 2 postdoctoral trainees an excellent opportunity to conduct environmental and molecular toxicology research in laboratories of investigators with international reputations. The mission of this training program is to development creative and independent research scientists who can address the complex problems presented by exposure to environmental toxicants.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES007324-15
Application #
8692777
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
New York University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
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Brocato, Jason; Costa, Max (2013) Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol 43:493-514
Arita, Adriana; Muñoz, Alexandra; Chervona, Yana et al. (2013) Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects. Cancer Epidemiol Biomarkers Prev 22:261-9
Passantino, Lisa; Muñoz, Alexandra B; Costa, Max (2013) Sodium metavanadate exhibits carcinogenic tendencies in vitro in immortalized human bronchial epithelial cells. Metallomics 5:1357-67

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